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Bloating and distension in irritable bowel syndrome: the role of gastrointestinal transit.
Am J Gastroenterol 2009; 104(8):1998-2004AJ

Abstract

OBJECTIVES

Patients with irritable bowel syndrome and constipation (IBS-C) show more abdominal distension than do those with diarrhea. Because constipation is often associated with delayed gastrointestinal transit, this study aimed at establishing whether patients with delayed transit show more distension and bloating than do those with normal transit.

METHODS

Abdominal girth was recorded for 24 h using abdominal inductance plethysmography (AIP) in 30 IBS-C (Rome II criteria) patients (aged 18-68 years; 27 women) and in 30 healthy volunteers (21-58 years of age; 26 women). Within 2 weeks of this recording, orocecal and colonic transits were assessed. Orocecal transit was determined from the increase in breath hydrogen after a standard meal, and colonic transit from the number of radio-opaque markers identified on a plain abdominal X-ray. Bloating severity was assessed hourly during AIP recording using a 0-5 scale.

RESULTS

IBS-C patients showed more bloating and distension than did healthy volunteers (P<0.001). They also had prolonged colonic (P<0.001) and orocecal (P=0.05) transits than did healthy volunteers, such that 47 and 17%, respectively, had colonic and orocecal transit times greater than the normal reference range. Those with delayed colonic (P=0.025) and orocecal (P=0.13) transits had greater distension but not bloating (P=0.63 and P=0.48, respectively) compared with those with normal transit. Moreover, distension directly correlated with orocecal (r=0.40; P=0.03) and colonic (r=0.51; P=0.004) transit times and inversely with stool consistency (r=-0.43; P=0.07).

CONCLUSIONS

IBS-C patients with delayed transit show greater abdominal distension than do those with normal transit. Therefore, drugs that accelerate transit may be expected to alleviate this troublesome problem.

Authors+Show Affiliations

Neurogastroenterology Unit, Gastrointestinal Sciences, School of Translational Medicine, University of Manchester, Manchester, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19491831

Citation

Agrawal, Anurag, et al. "Bloating and Distension in Irritable Bowel Syndrome: the Role of Gastrointestinal Transit." The American Journal of Gastroenterology, vol. 104, no. 8, 2009, pp. 1998-2004.
Agrawal A, Houghton LA, Reilly B, et al. Bloating and distension in irritable bowel syndrome: the role of gastrointestinal transit. Am J Gastroenterol. 2009;104(8):1998-2004.
Agrawal, A., Houghton, L. A., Reilly, B., Morris, J., & Whorwell, P. J. (2009). Bloating and distension in irritable bowel syndrome: the role of gastrointestinal transit. The American Journal of Gastroenterology, 104(8), pp. 1998-2004. doi:10.1038/ajg.2009.251.
Agrawal A, et al. Bloating and Distension in Irritable Bowel Syndrome: the Role of Gastrointestinal Transit. Am J Gastroenterol. 2009;104(8):1998-2004. PubMed PMID: 19491831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bloating and distension in irritable bowel syndrome: the role of gastrointestinal transit. AU - Agrawal,Anurag, AU - Houghton,Lesley A, AU - Reilly,Brian, AU - Morris,Julie, AU - Whorwell,Peter J, Y1 - 2009/06/02/ PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2009/8/21/medline SP - 1998 EP - 2004 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 104 IS - 8 N2 - OBJECTIVES: Patients with irritable bowel syndrome and constipation (IBS-C) show more abdominal distension than do those with diarrhea. Because constipation is often associated with delayed gastrointestinal transit, this study aimed at establishing whether patients with delayed transit show more distension and bloating than do those with normal transit. METHODS: Abdominal girth was recorded for 24 h using abdominal inductance plethysmography (AIP) in 30 IBS-C (Rome II criteria) patients (aged 18-68 years; 27 women) and in 30 healthy volunteers (21-58 years of age; 26 women). Within 2 weeks of this recording, orocecal and colonic transits were assessed. Orocecal transit was determined from the increase in breath hydrogen after a standard meal, and colonic transit from the number of radio-opaque markers identified on a plain abdominal X-ray. Bloating severity was assessed hourly during AIP recording using a 0-5 scale. RESULTS: IBS-C patients showed more bloating and distension than did healthy volunteers (P<0.001). They also had prolonged colonic (P<0.001) and orocecal (P=0.05) transits than did healthy volunteers, such that 47 and 17%, respectively, had colonic and orocecal transit times greater than the normal reference range. Those with delayed colonic (P=0.025) and orocecal (P=0.13) transits had greater distension but not bloating (P=0.63 and P=0.48, respectively) compared with those with normal transit. Moreover, distension directly correlated with orocecal (r=0.40; P=0.03) and colonic (r=0.51; P=0.004) transit times and inversely with stool consistency (r=-0.43; P=0.07). CONCLUSIONS: IBS-C patients with delayed transit show greater abdominal distension than do those with normal transit. Therefore, drugs that accelerate transit may be expected to alleviate this troublesome problem. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/19491831/Bloating_and_distension_in_irritable_bowel_syndrome:_the_role_of_gastrointestinal_transit_ L2 - http://Insights.ovid.com/pubmed?pmid=19491831 DB - PRIME DP - Unbound Medicine ER -