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Metronidazole loaded pectin microspheres for colon targeting.
J Pharm Sci. 2009 Nov; 98(11):4229-36.JP

Abstract

A multiparticulate system having pH-sensitive property and specific enzyme biodegradability for colon-targeted delivery of metronidazole was developed. Pectin microspheres were prepared using emulsion-dehydration technique. These microspheres were coated with Eudragit(R) S-100 using oil-in-oil solvent evaporation method. The SEM was used to characterize the surface of these microspheres and a distinct coating over microspheres could be seen. The in vitro drug release studies exhibited no drug release at gastric pH, however continuous release of drug was observed from the formulation at colonic pH. Further, the release of drug from formulation was found to be higher in the presence of rat caecal contents, indicating the effect of colonic enzymes on the pectin microspheres. The in vivo studies were also performed by assessing the drug concentration in various parts of the GIT at different time intervals which exhibited the potentiality of formulation for colon targeting. Hence, it can be concluded that Eudragit coated pectin microspheres can be used for the colon specific delivery of drug.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19492406

Citation

Vaidya, Ankur, et al. "Metronidazole Loaded Pectin Microspheres for Colon Targeting." Journal of Pharmaceutical Sciences, vol. 98, no. 11, 2009, pp. 4229-36.
Vaidya A, Jain A, Khare P, et al. Metronidazole loaded pectin microspheres for colon targeting. J Pharm Sci. 2009;98(11):4229-36.
Vaidya, A., Jain, A., Khare, P., Agrawal, R. K., & Jain, S. K. (2009). Metronidazole loaded pectin microspheres for colon targeting. Journal of Pharmaceutical Sciences, 98(11), 4229-36. https://doi.org/10.1002/jps.21742
Vaidya A, et al. Metronidazole Loaded Pectin Microspheres for Colon Targeting. J Pharm Sci. 2009;98(11):4229-36. PubMed PMID: 19492406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metronidazole loaded pectin microspheres for colon targeting. AU - Vaidya,Ankur, AU - Jain,Aviral, AU - Khare,Piush, AU - Agrawal,Ram K, AU - Jain,Sanjay K, PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2010/1/15/medline SP - 4229 EP - 36 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 98 IS - 11 N2 - A multiparticulate system having pH-sensitive property and specific enzyme biodegradability for colon-targeted delivery of metronidazole was developed. Pectin microspheres were prepared using emulsion-dehydration technique. These microspheres were coated with Eudragit(R) S-100 using oil-in-oil solvent evaporation method. The SEM was used to characterize the surface of these microspheres and a distinct coating over microspheres could be seen. The in vitro drug release studies exhibited no drug release at gastric pH, however continuous release of drug was observed from the formulation at colonic pH. Further, the release of drug from formulation was found to be higher in the presence of rat caecal contents, indicating the effect of colonic enzymes on the pectin microspheres. The in vivo studies were also performed by assessing the drug concentration in various parts of the GIT at different time intervals which exhibited the potentiality of formulation for colon targeting. Hence, it can be concluded that Eudragit coated pectin microspheres can be used for the colon specific delivery of drug. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/19492406/Metronidazole_loaded_pectin_microspheres_for_colon_targeting_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(15)32956-7 DB - PRIME DP - Unbound Medicine ER -