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Modifications in forced vital capacity during adenosine monophosphate-induced bronchoconstriction in asthma: relationship with the response to methacholine and the effect of inhaled corticosteroids.
Ann Allergy Asthma Immunol. 2009 May; 102(5):393-9.AA

Abstract

BACKGROUND

The effect of adenosine monophosphate (AMP) on forced vital capacity (FVC) has never been systematically investigated.

OBJECTIVE

To compare methacholine- and AMP-induced changes in FVC, as a marker of air trapping, in asthmatic patients treated and not treated with inhaled corticosteroids (ICSs).

METHODS

Airway responsiveness to equipotent concentrations of AMP and methacholine was obtained in asthmatic patients treated (n = 32) and not treated (n = 18) with ICSs. The response was expressed by the provocation concentration of agonist that caused a decrease in forced expiratory volume in 1 second (FEV1) of 20% (PC20) and by the slope of the FVC values recorded at each step of the challenge against the corresponding FEV1 values (sFVC).

RESULTS

Although methacholine and AMP PC20 values were similar in patients treated and not treated with ICSs, the mean (95% confidence interval) methacholine sFVC (but not AMP sFVC) was higher in those treated with ICSs (0.91; 0.77-1.06) than in those not taking ICSs (0.69; 0.57-0.81; P = .03). No significant correlation was found between sFVC and PC20 values obtained with either methacholine or AMP. Methacholine and AMP sFVC values were significantly related, but only in the group treated with ICSs (r = 0.60, P < .001).

CONCLUSIONS

Although the AMP-induced decline in FVC in asthmatic patients is similar to that observed with equipotent concentrations of methacholine, the apparently different effect of ICSs on changes in FVC induced by each agonist suggests that the information provided by the 2 bronchoconstrictor agents is not interchangeable and that the information generated by the analysis of the effect of each agonist on FEV1 and FVC may be complementary.

Authors+Show Affiliations

Sección de Alergologia, Asociacion Valenciana de Investigaciones Clinicas, Valencia, Spain prieto_jes@gva.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19492660

Citation

Prieto, Luis, et al. "Modifications in Forced Vital Capacity During Adenosine Monophosphate-induced Bronchoconstriction in Asthma: Relationship With the Response to Methacholine and the Effect of Inhaled Corticosteroids." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 102, no. 5, 2009, pp. 393-9.
Prieto L, López V, Catalan P, et al. Modifications in forced vital capacity during adenosine monophosphate-induced bronchoconstriction in asthma: relationship with the response to methacholine and the effect of inhaled corticosteroids. Ann Allergy Asthma Immunol. 2009;102(5):393-9.
Prieto, L., López, V., Catalan, P., Barato, D., & Marín, J. (2009). Modifications in forced vital capacity during adenosine monophosphate-induced bronchoconstriction in asthma: relationship with the response to methacholine and the effect of inhaled corticosteroids. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 102(5), 393-9. https://doi.org/10.1016/S1081-1206(10)60510-8
Prieto L, et al. Modifications in Forced Vital Capacity During Adenosine Monophosphate-induced Bronchoconstriction in Asthma: Relationship With the Response to Methacholine and the Effect of Inhaled Corticosteroids. Ann Allergy Asthma Immunol. 2009;102(5):393-9. PubMed PMID: 19492660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modifications in forced vital capacity during adenosine monophosphate-induced bronchoconstriction in asthma: relationship with the response to methacholine and the effect of inhaled corticosteroids. AU - Prieto,Luis, AU - López,Victoria, AU - Catalan,Pablo, AU - Barato,Desiree, AU - Marín,Julio, PY - 2009/6/5/entrez PY - 2009/6/6/pubmed PY - 2009/6/25/medline SP - 393 EP - 9 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 102 IS - 5 N2 - BACKGROUND: The effect of adenosine monophosphate (AMP) on forced vital capacity (FVC) has never been systematically investigated. OBJECTIVE: To compare methacholine- and AMP-induced changes in FVC, as a marker of air trapping, in asthmatic patients treated and not treated with inhaled corticosteroids (ICSs). METHODS: Airway responsiveness to equipotent concentrations of AMP and methacholine was obtained in asthmatic patients treated (n = 32) and not treated (n = 18) with ICSs. The response was expressed by the provocation concentration of agonist that caused a decrease in forced expiratory volume in 1 second (FEV1) of 20% (PC20) and by the slope of the FVC values recorded at each step of the challenge against the corresponding FEV1 values (sFVC). RESULTS: Although methacholine and AMP PC20 values were similar in patients treated and not treated with ICSs, the mean (95% confidence interval) methacholine sFVC (but not AMP sFVC) was higher in those treated with ICSs (0.91; 0.77-1.06) than in those not taking ICSs (0.69; 0.57-0.81; P = .03). No significant correlation was found between sFVC and PC20 values obtained with either methacholine or AMP. Methacholine and AMP sFVC values were significantly related, but only in the group treated with ICSs (r = 0.60, P < .001). CONCLUSIONS: Although the AMP-induced decline in FVC in asthmatic patients is similar to that observed with equipotent concentrations of methacholine, the apparently different effect of ICSs on changes in FVC induced by each agonist suggests that the information provided by the 2 bronchoconstrictor agents is not interchangeable and that the information generated by the analysis of the effect of each agonist on FEV1 and FVC may be complementary. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/19492660/Modifications_in_forced_vital_capacity_during_adenosine_monophosphate_induced_bronchoconstriction_in_asthma:_relationship_with_the_response_to_methacholine_and_the_effect_of_inhaled_corticosteroids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)60510-8 DB - PRIME DP - Unbound Medicine ER -