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Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: electrophysiological and behavioral evidence.
Pain. 2009 Aug; 144(3):320-8.PAIN

Abstract

Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological and behavioral consequences of the interactions between LTP and descending oxytocinergic antinociceptive mechanisms mediated by the hypothalamic paraventricular nucleus (PVN). PVN stimulation or intrathecal oxytocin (OT) reduced or prevented the ability of spinal LTP to facilitate selectively nociceptive-evoked responses of spinal wide dynamic range (WDR) neurons recorded in anesthetized rats. In a behavioral model developed to study the effects of spinal LTP on mechanical withdrawal thresholds in freely moving rats, the long-lasting LTP-mediated mechanical hyperalgesia was transiently interrupted or prevented by either PVN stimulation or intrathecal OT. LTP mediates long-lasting pain hypersensitivity that is strongly modulated by endogenous hypothalamic oxytocinergic descending controls.

Authors+Show Affiliations

Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19493620

Citation

DeLaTorre, Salvador, et al. "Paraventricular Oxytocinergic Hypothalamic Prevention or Interruption of Long-term Potentiation in Dorsal Horn Nociceptive Neurons: Electrophysiological and Behavioral Evidence." Pain, vol. 144, no. 3, 2009, pp. 320-8.
DeLaTorre S, Rojas-Piloni G, Martínez-Lorenzana G, et al. Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: electrophysiological and behavioral evidence. Pain. 2009;144(3):320-8.
DeLaTorre, S., Rojas-Piloni, G., Martínez-Lorenzana, G., Rodríguez-Jiménez, J., Villanueva, L., & Condés-Lara, M. (2009). Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: electrophysiological and behavioral evidence. Pain, 144(3), 320-8. https://doi.org/10.1016/j.pain.2009.05.002
DeLaTorre S, et al. Paraventricular Oxytocinergic Hypothalamic Prevention or Interruption of Long-term Potentiation in Dorsal Horn Nociceptive Neurons: Electrophysiological and Behavioral Evidence. Pain. 2009;144(3):320-8. PubMed PMID: 19493620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: electrophysiological and behavioral evidence. AU - DeLaTorre,Salvador, AU - Rojas-Piloni,Gerardo, AU - Martínez-Lorenzana,Guadalupe, AU - Rodríguez-Jiménez,Javier, AU - Villanueva,Luis, AU - Condés-Lara,Miguel, Y1 - 2009/06/02/ PY - 2008/11/27/received PY - 2009/04/23/revised PY - 2009/05/01/accepted PY - 2009/6/5/entrez PY - 2009/6/6/pubmed PY - 2009/10/1/medline SP - 320 EP - 8 JF - Pain JO - Pain VL - 144 IS - 3 N2 - Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological and behavioral consequences of the interactions between LTP and descending oxytocinergic antinociceptive mechanisms mediated by the hypothalamic paraventricular nucleus (PVN). PVN stimulation or intrathecal oxytocin (OT) reduced or prevented the ability of spinal LTP to facilitate selectively nociceptive-evoked responses of spinal wide dynamic range (WDR) neurons recorded in anesthetized rats. In a behavioral model developed to study the effects of spinal LTP on mechanical withdrawal thresholds in freely moving rats, the long-lasting LTP-mediated mechanical hyperalgesia was transiently interrupted or prevented by either PVN stimulation or intrathecal OT. LTP mediates long-lasting pain hypersensitivity that is strongly modulated by endogenous hypothalamic oxytocinergic descending controls. SN - 1872-6623 UR - https://www.unboundmedicine.com/medline/citation/19493620/Paraventricular_oxytocinergic_hypothalamic_prevention_or_interruption_of_long_term_potentiation_in_dorsal_horn_nociceptive_neurons:_electrophysiological_and_behavioral_evidence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3959(09)00266-8 DB - PRIME DP - Unbound Medicine ER -