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Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes.
J Alzheimers Dis. 2009; 17(1):7-31.JA

Abstract

Among lifestyle-related factors, low to moderate alcohol drinking has been proposed as a protective factor against the development of age-related changes in cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia, VaD) in several longitudinal studies, but contrasting findings also exist. Furthermore, many of these studies were limited by cross-sectional design, restriction by age or sex, or incomplete ascertainment. Different outcomes, beverages, drinking patterns, or follow-up periods, or possible interactions with other lifestyle-related (i.e., smoking) or genetic factors [i.e., apolipoprotein E (APOE) genotyping] may be sources of great variability. Light to moderate alcohol use may be associated with a reduced risk of unspecified incident dementia and AD, while for VaD, cognitive decline, and predementia syndromes, the current evidence is only suggestive of a protective effect. In conclusion, as intervention studies are not feasible in this area, the best evidence comes from an overview of epidemiological studies, suggesting that the protective effects are more likely with wine consumption and the absence of an APOE e4 allele. At present, there is no indication that light to moderate alcohol drinking would be harmful to cognition and dementia, and it is not possible to define a specific beneficial level of alcohol intake.

Authors+Show Affiliations

Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19494429

Citation

Panza, Francesco, et al. "Alcohol Drinking, Cognitive Functions in Older Age, Predementia, and Dementia Syndromes." Journal of Alzheimer's Disease : JAD, vol. 17, no. 1, 2009, pp. 7-31.
Panza F, Capurso C, D'Introno A, et al. Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes. J Alzheimers Dis. 2009;17(1):7-31.
Panza, F., Capurso, C., D'Introno, A., Colacicco, A. M., Frisardi, V., Lorusso, M., Santamato, A., Seripa, D., Pilotto, A., Scafato, E., Vendemiale, G., Capurso, A., & Solfrizzi, V. (2009). Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes. Journal of Alzheimer's Disease : JAD, 17(1), 7-31. https://doi.org/10.3233/JAD-2009-1009
Panza F, et al. Alcohol Drinking, Cognitive Functions in Older Age, Predementia, and Dementia Syndromes. J Alzheimers Dis. 2009;17(1):7-31. PubMed PMID: 19494429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes. AU - Panza,Francesco, AU - Capurso,Cristiano, AU - D'Introno,Alessia, AU - Colacicco,Anna M, AU - Frisardi,Vincenza, AU - Lorusso,Maria, AU - Santamato,Andrea, AU - Seripa,Davide, AU - Pilotto,Alberto, AU - Scafato,Emanuele, AU - Vendemiale,Gianluigi, AU - Capurso,Antonio, AU - Solfrizzi,Vincenzo, PY - 2009/6/5/entrez PY - 2009/6/6/pubmed PY - 2009/8/13/medline SP - 7 EP - 31 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 17 IS - 1 N2 - Among lifestyle-related factors, low to moderate alcohol drinking has been proposed as a protective factor against the development of age-related changes in cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia, VaD) in several longitudinal studies, but contrasting findings also exist. Furthermore, many of these studies were limited by cross-sectional design, restriction by age or sex, or incomplete ascertainment. Different outcomes, beverages, drinking patterns, or follow-up periods, or possible interactions with other lifestyle-related (i.e., smoking) or genetic factors [i.e., apolipoprotein E (APOE) genotyping] may be sources of great variability. Light to moderate alcohol use may be associated with a reduced risk of unspecified incident dementia and AD, while for VaD, cognitive decline, and predementia syndromes, the current evidence is only suggestive of a protective effect. In conclusion, as intervention studies are not feasible in this area, the best evidence comes from an overview of epidemiological studies, suggesting that the protective effects are more likely with wine consumption and the absence of an APOE e4 allele. At present, there is no indication that light to moderate alcohol drinking would be harmful to cognition and dementia, and it is not possible to define a specific beneficial level of alcohol intake. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/19494429/Alcohol_drinking_cognitive_functions_in_older_age_predementia_and_dementia_syndromes_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=17&issue=1&spage=7 DB - PRIME DP - Unbound Medicine ER -