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Association between ApoE epsilon4 and cognitive impairment after stroke.
Dement Geriatr Cogn Disord 2009; 27(6):525-33DG

Abstract

BACKGROUND AND PURPOSE

The understanding of the contribution of genetic factors to cognitive impairment after stroke is incomplete. The aim of the study was to examine whether the apolipoprotein E epsilon4 allele (ApoE epsilon4) is a risk factor for cognitive impairment in the early phase after stroke.

METHODS

The sample comprised 152 Norwegian stroke rehabilitation inpatients (mean age 76.8 years, SD 10.5) examined at a mean of 18.3 days (SD 13.4) after hospital admission. Post-stroke cognitive impairment was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The following proposed risk factors were analysed: ApoE genotype, demographics (age, sex, education), pre-stroke cognitive reduction [Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)], pre-stroke vascular factors (including previous stroke), stroke characteristics (type, location), and neurological stroke-related impairment [National Institutes of Health Stroke Scale (NIHSS)]. Cognitive impairment was defined as an RBANS total index score < or =1.5 SD below the mean. Multiple logistic regression analyses were performed to find risk factors for post-stroke cognitive impairment.

RESULTS

Four variables were found to be independent risk factors for cognitive impairment after stroke: ApoE epsilon4 (OR = 3.7; 95% CI = 1.2-11.6), IQCODE score > or =3.44 (OR = 9.2; 95% = CI 2.3-37.2), total or partial anterior stroke syndromes (OR = 3.2; 95% CI = 1.3-8.0), and NIHSS total score >5 (OR = 7.3; 95% CI = 2.7-19.7). No association between ApoE epsilon4 and pre-stroke cognitive reduction (IQCODE) was found.

CONCLUSIONS

The presence of one or two ApoE epsilon4 alleles may be a significant independent risk factor for cognitive impairment in the early phase after stroke.

Authors+Show Affiliations

Faculty of Medicine, University of Oslo, Oslo, Norway. jowagle@gmail.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19494491

Citation

Wagle, Jørgen, et al. "Association Between ApoE Epsilon4 and Cognitive Impairment After Stroke." Dementia and Geriatric Cognitive Disorders, vol. 27, no. 6, 2009, pp. 525-33.
Wagle J, Farner L, Flekkøy K, et al. Association between ApoE epsilon4 and cognitive impairment after stroke. Dement Geriatr Cogn Disord. 2009;27(6):525-33.
Wagle, J., Farner, L., Flekkøy, K., Wyller, T. B., Sandvik, L., Eiklid, K. L., ... Engedal, K. (2009). Association between ApoE epsilon4 and cognitive impairment after stroke. Dementia and Geriatric Cognitive Disorders, 27(6), pp. 525-33. doi:10.1159/000223230.
Wagle J, et al. Association Between ApoE Epsilon4 and Cognitive Impairment After Stroke. Dement Geriatr Cogn Disord. 2009;27(6):525-33. PubMed PMID: 19494491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between ApoE epsilon4 and cognitive impairment after stroke. AU - Wagle,Jørgen, AU - Farner,Lasse, AU - Flekkøy,Kjell, AU - Wyller,Torgeir Bruun, AU - Sandvik,Leiv, AU - Eiklid,Kristin L, AU - Fure,Brynjar, AU - Stensrød,Brynhild, AU - Engedal,Knut, Y1 - 2009/06/04/ PY - 2009/03/27/accepted PY - 2009/6/5/entrez PY - 2009/6/6/pubmed PY - 2009/10/6/medline SP - 525 EP - 33 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 27 IS - 6 N2 - BACKGROUND AND PURPOSE: The understanding of the contribution of genetic factors to cognitive impairment after stroke is incomplete. The aim of the study was to examine whether the apolipoprotein E epsilon4 allele (ApoE epsilon4) is a risk factor for cognitive impairment in the early phase after stroke. METHODS: The sample comprised 152 Norwegian stroke rehabilitation inpatients (mean age 76.8 years, SD 10.5) examined at a mean of 18.3 days (SD 13.4) after hospital admission. Post-stroke cognitive impairment was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The following proposed risk factors were analysed: ApoE genotype, demographics (age, sex, education), pre-stroke cognitive reduction [Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)], pre-stroke vascular factors (including previous stroke), stroke characteristics (type, location), and neurological stroke-related impairment [National Institutes of Health Stroke Scale (NIHSS)]. Cognitive impairment was defined as an RBANS total index score < or =1.5 SD below the mean. Multiple logistic regression analyses were performed to find risk factors for post-stroke cognitive impairment. RESULTS: Four variables were found to be independent risk factors for cognitive impairment after stroke: ApoE epsilon4 (OR = 3.7; 95% CI = 1.2-11.6), IQCODE score > or =3.44 (OR = 9.2; 95% = CI 2.3-37.2), total or partial anterior stroke syndromes (OR = 3.2; 95% CI = 1.3-8.0), and NIHSS total score >5 (OR = 7.3; 95% CI = 2.7-19.7). No association between ApoE epsilon4 and pre-stroke cognitive reduction (IQCODE) was found. CONCLUSIONS: The presence of one or two ApoE epsilon4 alleles may be a significant independent risk factor for cognitive impairment in the early phase after stroke. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/19494491/Association_between_ApoE_epsilon4_and_cognitive_impairment_after_stroke_ L2 - https://www.karger.com?DOI=10.1159/000223230 DB - PRIME DP - Unbound Medicine ER -