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Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population.
Med Princ Pract. 2009; 18(4):294-9.MP

Abstract

OBJECTIVES

The objective of this study was to investigate the possible association of clinical variables and apolipoprotein (APOE, APOCI and APOB) polymorphisms with the development of myocardial infraction (MI) and coronary heart disease (CHD) in Kuwaitis.

SUBJECTS AND METHODS

APOE, APOCI and APOB genotypes were determined by polymerase chain reaction followed by restriction fragment length polymorphism in 143 Kuwaiti CHD patients with (n = 88) and without (n = 55) MI and in 122 controls matched for gender and age. Statistical and genetic analyses of the genotype, allele and haplotype frequencies, as well as regression analyses of genetic and clinical variables were done.

RESULTS

There was a statistically significant association between CHD and medical history of diabetes mellitus (p < 0.001), hypertension (p < 0.01), high cholesterol (p < 0.05) and family history of CHD (p < 0.001). A highly significant association (p < 0.001) was found, with an adjusted odds ratio of 9.32, for family history and the development of MI. No significant differences were found for allele or genotype frequencies between CHD patients and controls.

CONCLUSION

The strong effect of family history suggests a major genetic component for the development of CHD in Kuwaitis, but this association does not appear to be related to the APO genes studied here. The results in this study encourages future research into these and other polymorphisms and their potential association with MI and CHD in the Kuwaiti population.

Authors+Show Affiliations

Department of Biological Sciences, Faculty of Science, Kuwait University, Safat 13060, Kuwait. s.albustan@ku.edu.kwNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19494537

Citation

Al-Bustan, Suzanne A., et al. "Apolipoprotein E, CI and B Gene Polymorphisms in a Sample of Patients With Coronary Heart Disease in the Kuwaiti Population." Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, vol. 18, no. 4, 2009, pp. 294-9.
Al-Bustan SA, Alkhalaf M, Al-Rashdan I, et al. Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population. Med Princ Pract. 2009;18(4):294-9.
Al-Bustan, S. A., Alkhalaf, M., Al-Rashdan, I., Al-Otaibi, S., Al-Baker, E., Balding, D., & Alnaqeeb, M. A. (2009). Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population. Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 18(4), 294-9. https://doi.org/10.1159/000215727
Al-Bustan SA, et al. Apolipoprotein E, CI and B Gene Polymorphisms in a Sample of Patients With Coronary Heart Disease in the Kuwaiti Population. Med Princ Pract. 2009;18(4):294-9. PubMed PMID: 19494537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population. AU - Al-Bustan,Suzanne A, AU - Alkhalaf,Moussa, AU - Al-Rashdan,Ibrahim, AU - Al-Otaibi,Salwa, AU - Al-Baker,Eman, AU - Balding,David, AU - Alnaqeeb,Majed A, Y1 - 2009/06/02/ PY - 2008/07/14/received PY - 2008/10/27/accepted PY - 2009/6/5/entrez PY - 2009/6/6/pubmed PY - 2009/8/19/medline SP - 294 EP - 9 JF - Medical principles and practice : international journal of the Kuwait University, Health Science Centre JO - Med Princ Pract VL - 18 IS - 4 N2 - OBJECTIVES: The objective of this study was to investigate the possible association of clinical variables and apolipoprotein (APOE, APOCI and APOB) polymorphisms with the development of myocardial infraction (MI) and coronary heart disease (CHD) in Kuwaitis. SUBJECTS AND METHODS: APOE, APOCI and APOB genotypes were determined by polymerase chain reaction followed by restriction fragment length polymorphism in 143 Kuwaiti CHD patients with (n = 88) and without (n = 55) MI and in 122 controls matched for gender and age. Statistical and genetic analyses of the genotype, allele and haplotype frequencies, as well as regression analyses of genetic and clinical variables were done. RESULTS: There was a statistically significant association between CHD and medical history of diabetes mellitus (p < 0.001), hypertension (p < 0.01), high cholesterol (p < 0.05) and family history of CHD (p < 0.001). A highly significant association (p < 0.001) was found, with an adjusted odds ratio of 9.32, for family history and the development of MI. No significant differences were found for allele or genotype frequencies between CHD patients and controls. CONCLUSION: The strong effect of family history suggests a major genetic component for the development of CHD in Kuwaitis, but this association does not appear to be related to the APO genes studied here. The results in this study encourages future research into these and other polymorphisms and their potential association with MI and CHD in the Kuwaiti population. SN - 1423-0151 UR - https://www.unboundmedicine.com/medline/citation/19494537/Apolipoprotein_E_CI_and_B_gene_polymorphisms_in_a_sample_of_patients_with_coronary_heart_disease_in_the_Kuwaiti_population_ L2 - https://www.karger.com?DOI=10.1159/000215727 DB - PRIME DP - Unbound Medicine ER -