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Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø Study, Tromsø, Norway.

Abstract

BACKGROUND

Platelet size, measured as mean platelet volume (MPV), is associated with platelet reactivity. MPV is increased in acute myocardial infarction, and has been identified as an independent risk factor for future myocardial infarction and stroke.

OBJECTIVES

The purpose of the study was to determine the impact of platelet count and MPV on the incidence of venous thromboembolism (VTE) in a prospective, population-based study.

METHODS

Platelet count, MPV and baseline characteristics were registered in 25 923 subjects aged 25-96 years who participated in the Tromsø Study in 1994-1995. Incident VTE events were registered to the end of follow-up (1 September 2007).

RESULTS

There were 445 validated incident VTE events (1.6 per 1000 person-years), of which 186 (42%) were unprovoked, during a mean of 10.8 years of follow-up. Subjects with MPV >or= 9.5 fL had a 1.3-fold [95% confidence interval (CI) 1.0-1.7] higher risk of total VTE and a 1.5-fold (95% CI 1.1-2.3) higher risk of unprovoked VTE than subjects with MPV < 8.5 fL in analyses adjusted for age, sex, smoking, body mass index, and platelet count. Increasing MPV was associated with increased risk of total VTE (P for trend = 0.09) and unprovoked VTE (P for trend = 0.03) in analyses adjusted for age and sex. There was no significant association between increasing platelet count and risk of VTE.

CONCLUSIONS

An increasing MPV was identified as a predictor for VTE, in particular VTE of unprovoked origin. The present findings support the concept that platelet reactivity is important in the pathogenesis of VTE.

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  • Authors+Show Affiliations

    ,

    Center for Atherothrombotic Research in Tromsø (CART), Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway. sigrid.brakkan@uit.no

    , , , ,

    Source

    MeSH

    Adult
    Blood Platelets
    Cell Size
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Norway
    Platelet Count
    Platelet Function Tests
    Population Surveillance
    Predictive Value of Tests
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Time Factors
    Venous Thromboembolism

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19496920

    Citation

    Braekkan, S K., et al. "Mean Platelet Volume Is a Risk Factor for Venous Thromboembolism: the Tromsø Study, Tromsø, Norway." Journal of Thrombosis and Haemostasis : JTH, vol. 8, no. 1, 2010, pp. 157-62.
    Braekkan SK, Mathiesen EB, Njølstad I, et al. Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø Study, Tromsø, Norway. J Thromb Haemost. 2010;8(1):157-62.
    Braekkan, S. K., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., Størmer, J., & Hansen, J. B. (2010). Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø Study, Tromsø, Norway. Journal of Thrombosis and Haemostasis : JTH, 8(1), pp. 157-62. doi:10.1111/j.1538-7836.2009.03498.x.
    Braekkan SK, et al. Mean Platelet Volume Is a Risk Factor for Venous Thromboembolism: the Tromsø Study, Tromsø, Norway. J Thromb Haemost. 2010;8(1):157-62. PubMed PMID: 19496920.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø Study, Tromsø, Norway. AU - Braekkan,S K, AU - Mathiesen,E B, AU - Njølstad,I, AU - Wilsgaard,T, AU - Størmer,J, AU - Hansen,J B, Y1 - 2009/05/30/ PY - 2009/6/6/entrez PY - 2009/6/6/pubmed PY - 2010/5/21/medline SP - 157 EP - 62 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 8 IS - 1 N2 - BACKGROUND: Platelet size, measured as mean platelet volume (MPV), is associated with platelet reactivity. MPV is increased in acute myocardial infarction, and has been identified as an independent risk factor for future myocardial infarction and stroke. OBJECTIVES: The purpose of the study was to determine the impact of platelet count and MPV on the incidence of venous thromboembolism (VTE) in a prospective, population-based study. METHODS: Platelet count, MPV and baseline characteristics were registered in 25 923 subjects aged 25-96 years who participated in the Tromsø Study in 1994-1995. Incident VTE events were registered to the end of follow-up (1 September 2007). RESULTS: There were 445 validated incident VTE events (1.6 per 1000 person-years), of which 186 (42%) were unprovoked, during a mean of 10.8 years of follow-up. Subjects with MPV >or= 9.5 fL had a 1.3-fold [95% confidence interval (CI) 1.0-1.7] higher risk of total VTE and a 1.5-fold (95% CI 1.1-2.3) higher risk of unprovoked VTE than subjects with MPV < 8.5 fL in analyses adjusted for age, sex, smoking, body mass index, and platelet count. Increasing MPV was associated with increased risk of total VTE (P for trend = 0.09) and unprovoked VTE (P for trend = 0.03) in analyses adjusted for age and sex. There was no significant association between increasing platelet count and risk of VTE. CONCLUSIONS: An increasing MPV was identified as a predictor for VTE, in particular VTE of unprovoked origin. The present findings support the concept that platelet reactivity is important in the pathogenesis of VTE. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/19496920/Mean_platelet_volume_is_a_risk_factor_for_venous_thromboembolism:_the_Tromsø_Study_Tromsø_Norway_ L2 - https://doi.org/10.1111/j.1538-7836.2009.03498.x DB - PRIME DP - Unbound Medicine ER -