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Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat.
Food Chem Toxicol. 2009 Aug; 47(8):2097-102.FC

Abstract

The aim of the present study was to evaluate the protective effect of palmatine, one of active ingredients of Coptidis rhizoma, against myocardial ischemia-reperfusion (I/R) injury is due to its antioxidant and anti-inflammatory action. Adult male rats were subjected to 30 min of ischemia and 6 or 24h of reperfusion. Rats were randomized to receive vehicle or palmatine 1h before reperfusion. Infarct size, myocardial function, and the antioxidant enzyme activity, such as malonaldehyde (MDA), lactate dehydrogenase (LDH), creatine phosphokinase (CK), superoxide dismutase (SOD) and catalase (CAT) were measured. Palmatine significantly improved I/R-induced myocardial dysfunction by increasing the values of the first derivative (+/-dp/dt) of left ventricular pressure and decreased infarct size by 50% (P<0.01 versus vehicle). As expected, palmatine markedly inhibited the increase of LDH, CK, and MDA contents in I/R rat serum, and it also significantly inhibited the decline of the activity of SOD and CAT in I/R cardiac tissues. In addition, COX-2 and iNOS expression in I/R myocardium was significantly reduced. Interestingly, palmatine increased heme oxygenase (HO)-1 induction in human aortic endothelial cells. We concluded that palmatine protects hearts from I/R injury in rats possibly by reducing oxidative stress and modulating inflammatory mediators.

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Authors+Show Affiliations

Kim YM
Department of Pharmacology, School of Medicine, and Institute of Health Sciences, Gyeongsang National University, 92 Chilamdong, Jinju, Republic of Korea.
Ha YM
No affiliation info available
Jin YC
No affiliation info available
Shi LY
No affiliation info available
Lee YS
No affiliation info available
Kim HJ
No affiliation info available
Seo HG
No affiliation info available
Choi JS
No affiliation info available
Kim YS
No affiliation info available
Kang SS
No affiliation info available
Lee JH
No affiliation info available
Chang KC
No affiliation info available

MeSH

AnimalsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsBerberine AlkaloidsBlotting, WesternCardiotonic AgentsCreatine KinaseDrugs, Chinese HerbalHemodynamicsL-Lactate DehydrogenaseMaleMalondialdehydeMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumRatsRats, Sprague-Dawley

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19497345

Citation

Kim, Young Min, et al. "Palmatine From Coptidis Rhizoma Reduces Ischemia-reperfusion-mediated Acute Myocardial Injury in the Rat." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 8, 2009, pp. 2097-102.
Kim YM, Ha YM, Jin YC, et al. Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat. Food Chem Toxicol. 2009;47(8):2097-102.
Kim, Y. M., Ha, Y. M., Jin, Y. C., Shi, L. Y., Lee, Y. S., Kim, H. J., Seo, H. G., Choi, J. S., Kim, Y. S., Kang, S. S., Lee, J. H., & Chang, K. C. (2009). Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(8), 2097-102. https://doi.org/10.1016/j.fct.2009.05.031
Kim YM, et al. Palmatine From Coptidis Rhizoma Reduces Ischemia-reperfusion-mediated Acute Myocardial Injury in the Rat. Food Chem Toxicol. 2009;47(8):2097-102. PubMed PMID: 19497345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat. AU - Kim,Young Min, AU - Ha,Yu Mi, AU - Jin,Yong Chun, AU - Shi,Lian Yu, AU - Lee,Yong Soo, AU - Kim,Hye Jung, AU - Seo,Han Geuk, AU - Choi,Jae Soo, AU - Kim,Yeong Shik, AU - Kang,Sam Sik, AU - Lee,Jae Heun, AU - Chang,Ki Churl, Y1 - 2009/06/02/ PY - 2009/03/18/received PY - 2009/04/27/revised PY - 2009/05/27/accepted PY - 2009/6/6/entrez PY - 2009/6/6/pubmed PY - 2009/10/20/medline SP - 2097 EP - 102 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 8 N2 - The aim of the present study was to evaluate the protective effect of palmatine, one of active ingredients of Coptidis rhizoma, against myocardial ischemia-reperfusion (I/R) injury is due to its antioxidant and anti-inflammatory action. Adult male rats were subjected to 30 min of ischemia and 6 or 24h of reperfusion. Rats were randomized to receive vehicle or palmatine 1h before reperfusion. Infarct size, myocardial function, and the antioxidant enzyme activity, such as malonaldehyde (MDA), lactate dehydrogenase (LDH), creatine phosphokinase (CK), superoxide dismutase (SOD) and catalase (CAT) were measured. Palmatine significantly improved I/R-induced myocardial dysfunction by increasing the values of the first derivative (+/-dp/dt) of left ventricular pressure and decreased infarct size by 50% (P<0.01 versus vehicle). As expected, palmatine markedly inhibited the increase of LDH, CK, and MDA contents in I/R rat serum, and it also significantly inhibited the decline of the activity of SOD and CAT in I/R cardiac tissues. In addition, COX-2 and iNOS expression in I/R myocardium was significantly reduced. Interestingly, palmatine increased heme oxygenase (HO)-1 induction in human aortic endothelial cells. We concluded that palmatine protects hearts from I/R injury in rats possibly by reducing oxidative stress and modulating inflammatory mediators. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19497345/Palmatine_from_Coptidis_rhizoma_reduces_ischemia_reperfusion_mediated_acute_myocardial_injury_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00259-2 DB - PRIME DP - Unbound Medicine ER -