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Identification of a bioactive compound isolated from Brazilian propolis type 6.
Bioorg Med Chem. 2009 Jul 15; 17(14):5332-5.BM

Abstract

A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.

Authors+Show Affiliations

Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903, Piracicaba, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19497755

Citation

Castro, Myrella Lessio, et al. "Identification of a Bioactive Compound Isolated From Brazilian Propolis Type 6." Bioorganic & Medicinal Chemistry, vol. 17, no. 14, 2009, pp. 5332-5.
Castro ML, do Nascimento AM, Ikegaki M, et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorg Med Chem. 2009;17(14):5332-5.
Castro, M. L., do Nascimento, A. M., Ikegaki, M., Costa-Neto, C. M., Alencar, S. M., & Rosalen, P. L. (2009). Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, 17(14), 5332-5. https://doi.org/10.1016/j.bmc.2009.04.066
Castro ML, et al. Identification of a Bioactive Compound Isolated From Brazilian Propolis Type 6. Bioorg Med Chem. 2009 Jul 15;17(14):5332-5. PubMed PMID: 19497755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of a bioactive compound isolated from Brazilian propolis type 6. AU - Castro,Myrella Lessio, AU - do Nascimento,Andréa Mendes, AU - Ikegaki,Masaharu, AU - Costa-Neto,Cláudio M, AU - Alencar,Severino M, AU - Rosalen,Pedro L, Y1 - 2009/05/03/ PY - 2009/02/26/received PY - 2009/04/28/revised PY - 2009/04/29/accepted PY - 2009/6/6/entrez PY - 2009/6/6/pubmed PY - 2009/10/9/medline SP - 5332 EP - 5 JF - Bioorganic & medicinal chemistry JO - Bioorg. Med. Chem. VL - 17 IS - 14 N2 - A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good. SN - 1464-3391 UR - https://www.unboundmedicine.com/medline/citation/19497755/Identification_of_a_bioactive_compound_isolated_from_Brazilian_propolis_type_6_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(09)00435-0 DB - PRIME DP - Unbound Medicine ER -