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Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries.
Dig Liver Dis. 2010 Jan; 42(1):55-60.DL

Abstract

AIM

The purpose of this study is to describe de novo post-liver transplant malignancies and compare their frequency with incidence rates from Italian cancer registries.

PATIENTS AND METHODS

Four hundred and seventeen patients subjected to liver transplantation, from 1991 to 2005, surviving for at least 30 days and without a previous diagnosis of cancer (including hepatocellular carcinoma), were evaluated for the development of de novo malignancies excluding non-melanoma skin cancers.

RESULTS

During a total follow-up time of 2856 person-years, 43 de novo malignancies were diagnosed in 43 liver transplantation recipients (10.3%). The most common cancers were non-Hodgkin lymphoma (9 cases), cancer of the head and neck (8 cases), Kaposi's sarcoma (6 cases) and esophageal carcinoma (5 cases). The 1, 3, 5 and 10 years estimated survival rates were 69%, 57%, 53% and 42%. Patients with de novo cancers had a lower 10-year survival rate than patients without cancers (58% versus 76%, p=0.005). The risk of cancer after liver transplantation was nearly 3-fold higher than that of the general population of the same age and sex (95% CI: 1.9-3.6). De novo tumour sites or types with significantly elevated SIR included Kaposi's sarcoma (SIR=144), non-Hodgkin lymphoma (SIR=13.8), esophagus (SIR=23.4), head and neck cancers (SIR=7) and cervix uteri (SIR=30.7).

CONCLUSIONS

Tumours after liver transplantation are associated with lower long-term survival, confirming that cancer is a major cause of late mortality in liver transplantation.

Authors+Show Affiliations

Department of Tissue & Organ Transplantation, University Hospital of Udine, Italy. umberto.baccarani@uniud.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19497797

Citation

Baccarani, U, et al. "Comparison of De Novo Tumours After Liver Transplantation With Incidence Rates From Italian Cancer Registries." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 42, no. 1, 2010, pp. 55-60.
Baccarani U, Piselli P, Serraino D, et al. Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries. Dig Liver Dis. 2010;42(1):55-60.
Baccarani, U., Piselli, P., Serraino, D., Adani, G. L., Lorenzin, D., Gambato, M., Buda, A., Zanus, G., Vitale, A., De Paoli, A., Cimaglia, C., Bresadola, V., Toniutto, P., Risaliti, A., Cillo, U., Bresadola, F., & Burra, P. (2010). Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 42(1), 55-60. https://doi.org/10.1016/j.dld.2009.04.017
Baccarani U, et al. Comparison of De Novo Tumours After Liver Transplantation With Incidence Rates From Italian Cancer Registries. Dig Liver Dis. 2010;42(1):55-60. PubMed PMID: 19497797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries. AU - Baccarani,U, AU - Piselli,P, AU - Serraino,D, AU - Adani,G L, AU - Lorenzin,D, AU - Gambato,M, AU - Buda,A, AU - Zanus,G, AU - Vitale,A, AU - De Paoli,A, AU - Cimaglia,C, AU - Bresadola,V, AU - Toniutto,P, AU - Risaliti,A, AU - Cillo,U, AU - Bresadola,F, AU - Burra,P, Y1 - 2009/06/03/ PY - 2008/09/30/received PY - 2009/03/31/revised PY - 2009/04/28/accepted PY - 2009/6/6/entrez PY - 2009/6/6/pubmed PY - 2010/6/3/medline SP - 55 EP - 60 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 42 IS - 1 N2 - AIM: The purpose of this study is to describe de novo post-liver transplant malignancies and compare their frequency with incidence rates from Italian cancer registries. PATIENTS AND METHODS: Four hundred and seventeen patients subjected to liver transplantation, from 1991 to 2005, surviving for at least 30 days and without a previous diagnosis of cancer (including hepatocellular carcinoma), were evaluated for the development of de novo malignancies excluding non-melanoma skin cancers. RESULTS: During a total follow-up time of 2856 person-years, 43 de novo malignancies were diagnosed in 43 liver transplantation recipients (10.3%). The most common cancers were non-Hodgkin lymphoma (9 cases), cancer of the head and neck (8 cases), Kaposi's sarcoma (6 cases) and esophageal carcinoma (5 cases). The 1, 3, 5 and 10 years estimated survival rates were 69%, 57%, 53% and 42%. Patients with de novo cancers had a lower 10-year survival rate than patients without cancers (58% versus 76%, p=0.005). The risk of cancer after liver transplantation was nearly 3-fold higher than that of the general population of the same age and sex (95% CI: 1.9-3.6). De novo tumour sites or types with significantly elevated SIR included Kaposi's sarcoma (SIR=144), non-Hodgkin lymphoma (SIR=13.8), esophagus (SIR=23.4), head and neck cancers (SIR=7) and cervix uteri (SIR=30.7). CONCLUSIONS: Tumours after liver transplantation are associated with lower long-term survival, confirming that cancer is a major cause of late mortality in liver transplantation. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/19497797/Comparison_of_de_novo_tumours_after_liver_transplantation_with_incidence_rates_from_Italian_cancer_registries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(09)00220-5 DB - PRIME DP - Unbound Medicine ER -