TY - JOUR T1 - Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries. AU - Baccarani,U, AU - Piselli,P, AU - Serraino,D, AU - Adani,G L, AU - Lorenzin,D, AU - Gambato,M, AU - Buda,A, AU - Zanus,G, AU - Vitale,A, AU - De Paoli,A, AU - Cimaglia,C, AU - Bresadola,V, AU - Toniutto,P, AU - Risaliti,A, AU - Cillo,U, AU - Bresadola,F, AU - Burra,P, Y1 - 2009/06/03/ PY - 2008/09/30/received PY - 2009/03/31/revised PY - 2009/04/28/accepted PY - 2009/6/6/entrez PY - 2009/6/6/pubmed PY - 2010/6/3/medline SP - 55 EP - 60 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 42 IS - 1 N2 - AIM: The purpose of this study is to describe de novo post-liver transplant malignancies and compare their frequency with incidence rates from Italian cancer registries. PATIENTS AND METHODS: Four hundred and seventeen patients subjected to liver transplantation, from 1991 to 2005, surviving for at least 30 days and without a previous diagnosis of cancer (including hepatocellular carcinoma), were evaluated for the development of de novo malignancies excluding non-melanoma skin cancers. RESULTS: During a total follow-up time of 2856 person-years, 43 de novo malignancies were diagnosed in 43 liver transplantation recipients (10.3%). The most common cancers were non-Hodgkin lymphoma (9 cases), cancer of the head and neck (8 cases), Kaposi's sarcoma (6 cases) and esophageal carcinoma (5 cases). The 1, 3, 5 and 10 years estimated survival rates were 69%, 57%, 53% and 42%. Patients with de novo cancers had a lower 10-year survival rate than patients without cancers (58% versus 76%, p=0.005). The risk of cancer after liver transplantation was nearly 3-fold higher than that of the general population of the same age and sex (95% CI: 1.9-3.6). De novo tumour sites or types with significantly elevated SIR included Kaposi's sarcoma (SIR=144), non-Hodgkin lymphoma (SIR=13.8), esophagus (SIR=23.4), head and neck cancers (SIR=7) and cervix uteri (SIR=30.7). CONCLUSIONS: Tumours after liver transplantation are associated with lower long-term survival, confirming that cancer is a major cause of late mortality in liver transplantation. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/19497797/Comparison_of_de_novo_tumours_after_liver_transplantation_with_incidence_rates_from_Italian_cancer_registries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(09)00220-5 DB - PRIME DP - Unbound Medicine ER -