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Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study.
Thorax. 2009 Sep; 64(9):815-21.T

Abstract

BACKGROUND

One factor capable of modulating antenatal immune responses is diet. This prospective study examined the association between maternal intake of specific types of fatty acids, cholesterol, fish and meat during pregnancy and the risk of wheeze and eczema in the offspring.

METHODS

Subjects were 763 mother-child pairs. Data on maternal intake during pregnancy were assessed with a diet history questionnaire. Data on wheeze and eczema based on criteria of the International Study of Asthma and Allergies in Childhood were obtained from a questionnaire completed by mothers 16-24 months postpartum.

RESULTS

Higher maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy was independently associated with a reduced risk of wheeze, but not eczema, in the offspring (adjusted odds ratios (ORs) between extreme quartiles 0.52 (95% CI 0.28 to 0.97) and 0.37 (95% CI 0.15 to 0.91), respectively). Higher maternal intake of n-6 polyunsaturated fatty acids and linoleic acid during pregnancy was independently related to an increased risk of infantile eczema but not wheeze (adjusted ORs 2.25 (95% CI 1.13 to 4.54) and 2.11 (95% CI 1.06 to 4.26), respectively). No significant exposure-response relationships were observed between maternal consumption of total fat, saturated fatty acids, monounsaturated fatty acids, eicosapentaenoic acid, arachidonic acid, cholesterol, meat and fish and the ratio of n-3 to n-6 polyunsaturated fatty acid consumption during pregnancy and infantile wheeze or eczema.

CONCLUSIONS

Maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy may be preventive against infantile wheeze. Maternal intake of n-6 polyunsaturated fatty acids, especially linoleic acid, during pregnancy may increase the risk of childhood eczema.

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Authors+Show Affiliations

Miyake Y
Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan. miyake-y@fukuoka-u.ac.jp
Sasaki S
No affiliation info available
Tanaka K
No affiliation info available
Ohfuji S
No affiliation info available
Hirota Y
No affiliation info available

MeSH

Dermatitis, AtopicDietDietary FatsEpidemiologic MethodsFatty AcidsFemaleHumansInfantJapanMeatPregnancyPrenatal Exposure Delayed EffectsPrenatal Nutritional Physiological PhenomenaRespiratory Sounds

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19497922

Citation

Miyake, Y, et al. "Maternal Fat Consumption During Pregnancy and Risk of Wheeze and Eczema in Japanese Infants Aged 16-24 Months: the Osaka Maternal and Child Health Study." Thorax, vol. 64, no. 9, 2009, pp. 815-21.
Miyake Y, Sasaki S, Tanaka K, et al. Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study. Thorax. 2009;64(9):815-21.
Miyake, Y., Sasaki, S., Tanaka, K., Ohfuji, S., & Hirota, Y. (2009). Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study. Thorax, 64(9), 815-21. https://doi.org/10.1136/thx.2009.115931
Miyake Y, et al. Maternal Fat Consumption During Pregnancy and Risk of Wheeze and Eczema in Japanese Infants Aged 16-24 Months: the Osaka Maternal and Child Health Study. Thorax. 2009;64(9):815-21. PubMed PMID: 19497922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study. AU - Miyake,Y, AU - Sasaki,S, AU - Tanaka,K, AU - Ohfuji,S, AU - Hirota,Y, Y1 - 2009/06/03/ PY - 2009/6/6/entrez PY - 2009/6/6/pubmed PY - 2010/3/2/medline SP - 815 EP - 21 JF - Thorax JO - Thorax VL - 64 IS - 9 N2 - BACKGROUND: One factor capable of modulating antenatal immune responses is diet. This prospective study examined the association between maternal intake of specific types of fatty acids, cholesterol, fish and meat during pregnancy and the risk of wheeze and eczema in the offspring. METHODS: Subjects were 763 mother-child pairs. Data on maternal intake during pregnancy were assessed with a diet history questionnaire. Data on wheeze and eczema based on criteria of the International Study of Asthma and Allergies in Childhood were obtained from a questionnaire completed by mothers 16-24 months postpartum. RESULTS: Higher maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy was independently associated with a reduced risk of wheeze, but not eczema, in the offspring (adjusted odds ratios (ORs) between extreme quartiles 0.52 (95% CI 0.28 to 0.97) and 0.37 (95% CI 0.15 to 0.91), respectively). Higher maternal intake of n-6 polyunsaturated fatty acids and linoleic acid during pregnancy was independently related to an increased risk of infantile eczema but not wheeze (adjusted ORs 2.25 (95% CI 1.13 to 4.54) and 2.11 (95% CI 1.06 to 4.26), respectively). No significant exposure-response relationships were observed between maternal consumption of total fat, saturated fatty acids, monounsaturated fatty acids, eicosapentaenoic acid, arachidonic acid, cholesterol, meat and fish and the ratio of n-3 to n-6 polyunsaturated fatty acid consumption during pregnancy and infantile wheeze or eczema. CONCLUSIONS: Maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy may be preventive against infantile wheeze. Maternal intake of n-6 polyunsaturated fatty acids, especially linoleic acid, during pregnancy may increase the risk of childhood eczema. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/19497922/Maternal_fat_consumption_during_pregnancy_and_risk_of_wheeze_and_eczema_in_Japanese_infants_aged_16_24_months:_the_Osaka_Maternal_and_Child_Health_Study_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=19497922 DB - PRIME DP - Unbound Medicine ER -