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The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus.
J Endocrinol Invest. 2009 Jul; 32(7):606-10.JE

Abstract

BACKGROUND

There is an ongoing debate whether maternal diabetes is a more important risk factor for gestational diabetes (GDM) development than paternal diabetes.

AIM

To describe the risk of GDM associated with paternal and maternal diabetes, and to further characterise GDM women with maternal diabetes.

SUBJECTS AND METHODS

Case-control study within a population-based GDM screening program in an urban area of Hungary in 2002-2003. All GDM women (no.=133) and an age-matched control group (no.=135) with a mean age of 31 years was evaluated. Blood pressure, anthropometric data, and blood glucose values from a 75 g Oral Glucose Tolerance Test (OGTT) were recorded at 24-28 weeks of gestation. Family history data were by self-report.

RESULTS

Known paternal diabetes was not related to GDM risk [odds ratio (OR) 0.83, 95% confidence interval (CI) 0.35-2.00]. Known maternal diabetes (OR 2.90, 95% CI 0.99-8.49) and diabetes in the maternal line (OR 2.83, 95% CI 1.16-6.89) were both related to GDM after adjustment for body mass index (BMI). GDM women with known maternal diabetes had a higher BMI, 31.6 [9.1] kg/m2 median [interquartile range], than GDM women with or without diabetes in the maternal line, 26.1 [4.9] and 26.3 [6.1] kg/m2, respectively, while figures for fasting glucose during OGTT were 5.2 [0.7] vs 4.4 [1.1] vs 4.9 [0.8] mmol/l respectively (all p<0.05).

CONCLUSIONS

Maternal history of diabetes and history of diabetes in the maternal line seems to be a stronger predictor of GDM than paternal history.

Authors+Show Affiliations

National Centre for Diabetes Care, Budapest, Hungary. a.tabak@ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19498321

Citation

Tabák, A G., et al. "The Effect of Paternal and Maternal History of Diabetes Mellitus On the Development of Gestational Diabetes Mellitus." Journal of Endocrinological Investigation, vol. 32, no. 7, 2009, pp. 606-10.
Tabák AG, Tamás G, Péterfalvi A, et al. The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus. J Endocrinol Invest. 2009;32(7):606-10.
Tabák, A. G., Tamás, G., Péterfalvi, A., Bosnyák, Z., Madarász, E., Rákóczi, I., & Kerényi, Z. (2009). The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus. Journal of Endocrinological Investigation, 32(7), 606-10. https://doi.org/10.1007/BF03346517
Tabák AG, et al. The Effect of Paternal and Maternal History of Diabetes Mellitus On the Development of Gestational Diabetes Mellitus. J Endocrinol Invest. 2009;32(7):606-10. PubMed PMID: 19498321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus. AU - Tabák,A G, AU - Tamás,G, AU - Péterfalvi,A, AU - Bosnyák,Z, AU - Madarász,E, AU - Rákóczi,I, AU - Kerényi,Z, Y1 - 2009/05/15/ PY - 2009/6/6/entrez PY - 2009/6/6/pubmed PY - 2010/1/12/medline SP - 606 EP - 10 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 32 IS - 7 N2 - BACKGROUND: There is an ongoing debate whether maternal diabetes is a more important risk factor for gestational diabetes (GDM) development than paternal diabetes. AIM: To describe the risk of GDM associated with paternal and maternal diabetes, and to further characterise GDM women with maternal diabetes. SUBJECTS AND METHODS: Case-control study within a population-based GDM screening program in an urban area of Hungary in 2002-2003. All GDM women (no.=133) and an age-matched control group (no.=135) with a mean age of 31 years was evaluated. Blood pressure, anthropometric data, and blood glucose values from a 75 g Oral Glucose Tolerance Test (OGTT) were recorded at 24-28 weeks of gestation. Family history data were by self-report. RESULTS: Known paternal diabetes was not related to GDM risk [odds ratio (OR) 0.83, 95% confidence interval (CI) 0.35-2.00]. Known maternal diabetes (OR 2.90, 95% CI 0.99-8.49) and diabetes in the maternal line (OR 2.83, 95% CI 1.16-6.89) were both related to GDM after adjustment for body mass index (BMI). GDM women with known maternal diabetes had a higher BMI, 31.6 [9.1] kg/m2 median [interquartile range], than GDM women with or without diabetes in the maternal line, 26.1 [4.9] and 26.3 [6.1] kg/m2, respectively, while figures for fasting glucose during OGTT were 5.2 [0.7] vs 4.4 [1.1] vs 4.9 [0.8] mmol/l respectively (all p<0.05). CONCLUSIONS: Maternal history of diabetes and history of diabetes in the maternal line seems to be a stronger predictor of GDM than paternal history. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/19498321/The_effect_of_paternal_and_maternal_history_of_diabetes_mellitus_on_the_development_of_gestational_diabetes_mellitus_ L2 - https://link.springer.com/article/10.1007/BF03346517 DB - PRIME DP - Unbound Medicine ER -