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Mouririelliptica: validation of gastroprotective, healing and anti-Helicobacter pylori effects.
J Ethnopharmacol. 2009 Jun 25; 123(3):359-68.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Mouriri elliptica Martius (Melastomataceae) is species reputed in folk medicine to heal gastric ulcer and gastritis.

AIM OF THE STUDY

Methanolic extract (ME) and ethyl acetate fraction (EAF) from leaves of Mouriri elliptica were evaluated for their gastroprotective, healing, immunological, toxicological and anti-Helicobacter pylori activities.

MATERIAL AND METHODS

The gastroprotective action of ME and EAF was evaluated in rodent experimental models and to elucidate mechanisms of action, the antisecretory action, involvements of NO, SH, PGE(2), anti-Helicobacter pylori action of ME was evaluated. We also used immunohistochemical (PCNA and COX-2) and immunomodulatory (murine peritoneal macrophages) assays to evaluate Mouriri elliptica effects.

RESULTS

ME present gastroprotective action without antisecretory effect. Otherwise, ME showed anti-Helicobacter pylori action (MIC=0.025mug/mL) and was able to inhibit NO production by macrophages. This species also accelerate the healing of ulcerated gastric mucosa by stimulating proliferation factors (PCNA), COX-2 and maintained basal PGE(2) level independent action of NSAID in gastric mucosa. The phytochemical investigation showed that this species possesses phenolic acid derivatives, acylglycoflavonoids and condensed tannins which probably influenced their pharmacological action.

CONCLUSION

All these results suggest the efficacy and safety of Mouriri elliptica in combating and healing gastric ulcer.

Authors+Show Affiliations

São Paulo State University-Departamento de Fisiologia, Instituto de Biociências, Cp 610, CEP 18618-000, UNESP, Botucatu, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

19501267

Citation

Moleiro, Fábio Cruz, et al. "Mouririelliptica: Validation of Gastroprotective, Healing and anti-Helicobacter Pylori Effects." Journal of Ethnopharmacology, vol. 123, no. 3, 2009, pp. 359-68.
Moleiro FC, Andreo MA, Santos Rde C, et al. Mouririelliptica: validation of gastroprotective, healing and anti-Helicobacter pylori effects. J Ethnopharmacol. 2009;123(3):359-68.
Moleiro, F. C., Andreo, M. A., Santos, R. d. e. . C., Moraes, T. d. e. . M., Rodrigues, C. M., Carli, C. B., Lopes, F. C., Pellizzon, C. H., Carlos, I. Z., Bauab, T. M., Vilegas, W., & Hiruma-Lima, C. A. (2009). Mouririelliptica: validation of gastroprotective, healing and anti-Helicobacter pylori effects. Journal of Ethnopharmacology, 123(3), 359-68. https://doi.org/10.1016/j.jep.2009.03.040
Moleiro FC, et al. Mouririelliptica: Validation of Gastroprotective, Healing and anti-Helicobacter Pylori Effects. J Ethnopharmacol. 2009 Jun 25;123(3):359-68. PubMed PMID: 19501267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mouririelliptica: validation of gastroprotective, healing and anti-Helicobacter pylori effects. AU - Moleiro,Fábio Cruz, AU - Andreo,Márcio Aparecido, AU - Santos,Raquel de Cássia Dos, AU - Moraes,Thiago de Mello, AU - Rodrigues,Clenilson Martins, AU - Carli,Camila Bernardes de Andrade, AU - Lopes,Flávia Cristine Mascia, AU - Pellizzon,Cláudia Helena, AU - Carlos,Iracilda Zeppone, AU - Bauab,Tais Maria, AU - Vilegas,Wagner, AU - Hiruma-Lima,Clélia Akiko, Y1 - 2009/04/05/ PY - 2009/01/26/received PY - 2009/03/21/revised PY - 2009/03/25/accepted PY - 2009/6/9/entrez PY - 2009/6/9/pubmed PY - 2009/10/9/medline SP - 359 EP - 68 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 123 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Mouriri elliptica Martius (Melastomataceae) is species reputed in folk medicine to heal gastric ulcer and gastritis. AIM OF THE STUDY: Methanolic extract (ME) and ethyl acetate fraction (EAF) from leaves of Mouriri elliptica were evaluated for their gastroprotective, healing, immunological, toxicological and anti-Helicobacter pylori activities. MATERIAL AND METHODS: The gastroprotective action of ME and EAF was evaluated in rodent experimental models and to elucidate mechanisms of action, the antisecretory action, involvements of NO, SH, PGE(2), anti-Helicobacter pylori action of ME was evaluated. We also used immunohistochemical (PCNA and COX-2) and immunomodulatory (murine peritoneal macrophages) assays to evaluate Mouriri elliptica effects. RESULTS: ME present gastroprotective action without antisecretory effect. Otherwise, ME showed anti-Helicobacter pylori action (MIC=0.025mug/mL) and was able to inhibit NO production by macrophages. This species also accelerate the healing of ulcerated gastric mucosa by stimulating proliferation factors (PCNA), COX-2 and maintained basal PGE(2) level independent action of NSAID in gastric mucosa. The phytochemical investigation showed that this species possesses phenolic acid derivatives, acylglycoflavonoids and condensed tannins which probably influenced their pharmacological action. CONCLUSION: All these results suggest the efficacy and safety of Mouriri elliptica in combating and healing gastric ulcer. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19501267/Mouririelliptica:_validation_of_gastroprotective_healing_and_anti_Helicobacter_pylori_effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00196-2 DB - PRIME DP - Unbound Medicine ER -