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Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action.
J Ethnopharmacol. 2009 Jun 25; 123(3):430-8.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Davilla elliptica and Davilla nitida are species commonly found in the Brazilian Cerrado biome.

AIM OF THE STUDY

Based on ethnopharmacological and phytochemical analyses, methanolic extracts from leaves of Davilla elliptica (EDE) and Davilla nitida (EDN) were evaluated for their anti-ulcer, anti-inflammatory, immunological and anti-Helicobacter pylori activities.

MATERIALS AND METHODS

The gastroprotective action of both extracts was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated anti-inflammatory (carrageenin-induced rat hind paw edema), immunomodulatory (murine peritoneal macrophages) and antibacterial action of both extracts against a standard strain of Helicobacter pylori.

RESULTS

EDE and EDN (500 mg/kg) were able to protect gastric mucosa against HCl/ethanol solution (EDE 63%; EDN 59%), absolute ethanol (EDE 95%; EDN 88%), and also against injurious effect of NSAID (EDE 77%; EDN 67%). When EDE and EDN were challenged with sulfhydryl depleter compound, the gastroprotective action of both extracts was completely abolished. EDE had gastroprotective effect related to increase of glutathione bioavailability and stimulated higher levels of NO, H2O2 and TNF-alpha production. Otherwise EDN showed better anti-Helicobacter pylori action than EDE. Neither extracts presented anti-inflammatory activity by oral route.

CONCLUSION

The phytochemical investigation showed that both extracts possess phenolic acid derivatives, acylglycoflavonoids and condensed tannins with evident quantitative variations that probably influenced the pharmacological differences between extracts.

Authors+Show Affiliations

Physiology Department, Biosciences Institute, São Paulo State University, C.P. 510, 18618-000 UNESP, Botucatu, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19501275

Citation

Kushima, Hélio, et al. "Davilla Elliptica and Davilla Nitida: Gastroprotective, Anti-inflammatory Immunomodulatory and anti-Helicobacter Pylori Action." Journal of Ethnopharmacology, vol. 123, no. 3, 2009, pp. 430-8.
Kushima H, Nishijima CM, Rodrigues CM, et al. Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action. J Ethnopharmacol. 2009;123(3):430-8.
Kushima, H., Nishijima, C. M., Rodrigues, C. M., Rinaldo, D., Sassá, M. F., Bauab, T. M., Stasi, L. C., Carlos, I. Z., Brito, A. R., Vilegas, W., & Hiruma-Lima, C. A. (2009). Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action. Journal of Ethnopharmacology, 123(3), 430-8. https://doi.org/10.1016/j.jep.2009.03.031
Kushima H, et al. Davilla Elliptica and Davilla Nitida: Gastroprotective, Anti-inflammatory Immunomodulatory and anti-Helicobacter Pylori Action. J Ethnopharmacol. 2009 Jun 25;123(3):430-8. PubMed PMID: 19501275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Davilla elliptica and Davilla nitida: gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action. AU - Kushima,Hélio, AU - Nishijima,Catarine Massucato, AU - Rodrigues,Clenilson Martins, AU - Rinaldo,Daniel, AU - Sassá,Micheli Fernanda, AU - Bauab,Taís Maria, AU - Stasi,Luiz Claudio Di, AU - Carlos,Iracilda Zeppone, AU - Brito,Alba Regina Monteiro Souza, AU - Vilegas,Wagner, AU - Hiruma-Lima,Clélia Akiko, Y1 - 2009/03/31/ PY - 2008/11/05/received PY - 2009/03/20/revised PY - 2009/03/21/accepted PY - 2009/6/9/entrez PY - 2009/6/9/pubmed PY - 2009/10/9/medline SP - 430 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 123 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Davilla elliptica and Davilla nitida are species commonly found in the Brazilian Cerrado biome. AIM OF THE STUDY: Based on ethnopharmacological and phytochemical analyses, methanolic extracts from leaves of Davilla elliptica (EDE) and Davilla nitida (EDN) were evaluated for their anti-ulcer, anti-inflammatory, immunological and anti-Helicobacter pylori activities. MATERIALS AND METHODS: The gastroprotective action of both extracts was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated anti-inflammatory (carrageenin-induced rat hind paw edema), immunomodulatory (murine peritoneal macrophages) and antibacterial action of both extracts against a standard strain of Helicobacter pylori. RESULTS: EDE and EDN (500 mg/kg) were able to protect gastric mucosa against HCl/ethanol solution (EDE 63%; EDN 59%), absolute ethanol (EDE 95%; EDN 88%), and also against injurious effect of NSAID (EDE 77%; EDN 67%). When EDE and EDN were challenged with sulfhydryl depleter compound, the gastroprotective action of both extracts was completely abolished. EDE had gastroprotective effect related to increase of glutathione bioavailability and stimulated higher levels of NO, H2O2 and TNF-alpha production. Otherwise EDN showed better anti-Helicobacter pylori action than EDE. Neither extracts presented anti-inflammatory activity by oral route. CONCLUSION: The phytochemical investigation showed that both extracts possess phenolic acid derivatives, acylglycoflavonoids and condensed tannins with evident quantitative variations that probably influenced the pharmacological differences between extracts. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19501275/Davilla_elliptica_and_Davilla_nitida:_gastroprotective_anti_inflammatory_immunomodulatory_and_anti_Helicobacter_pylori_action_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00187-1 DB - PRIME DP - Unbound Medicine ER -