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Antiulcer activity of methanolic extract of Momordica charantia L. in rats.
J Ethnopharmacol. 2009 Jun 25; 123(3):464-9.JE

Abstract

AIM OF THE STUDY

Momordica charantia L. (Cucurbitaceae) commonly known as 'bitter gourd' is a multi purpose herb cultivated in different parts of the world for its edible fruits. The objective of the present study was to evaluate the effect of standardized methanolic extract of Momordica charantia L. fruits on gastric and duodenal ulcers.

MATERIALS AND METHODS

The effect was evaluated in acetic acid induced chronic gastric ulcer, pylorus ligation induced gastric ulcer, ethanol induced gastric ulcer, stress induced gastric ulcer, indomethacin induced gastric ulcer and cysteamine induced duodenal ulcer model. The extract was administered orally at two different doses of 100 mg/kg and 500 mg/kg.

RESULTS

The healing of acetic acid induced gastric ulcer was increased by both doses of the extract. In pylorus-ligated rats, the extract showed significant decrease in ulcer index, total acidity, free acidity and pepsin content and an increase in gastric mucosal content. The extract also reduced the ulcer index in stress induced, ethanol induced and indomethacin induced gastric ulcers and cysteamine induced duodenal ulcer.

CONCLUSION

The methanolic extract of Momordica charantia L. fruit increases healing of gastric ulcer and also prevents development of gastric ulcers and duodenal ulcers in rats.

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Authors+Show Affiliations

Alam S
Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore 560034, India.
Asad M
No affiliation info available
Asdaq SM
No affiliation info available
Prasad VS
No affiliation info available

MeSH

AnimalsAnti-Ulcer AgentsDisease Models, AnimalDuodenal UlcerFemaleFruitMaleMomordica charantiaMucinsPhytotherapyPlant ExtractsPlants, MedicinalProteinsRatsRats, WistarStomach Ulcer

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

19501279

Citation

Alam, Samsul, et al. "Antiulcer Activity of Methanolic Extract of Momordica Charantia L. in Rats." Journal of Ethnopharmacology, vol. 123, no. 3, 2009, pp. 464-9.
Alam S, Asad M, Asdaq SM, et al. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J Ethnopharmacol. 2009;123(3):464-9.
Alam, S., Asad, M., Asdaq, S. M., & Prasad, V. S. (2009). Antiulcer activity of methanolic extract of Momordica charantia L. in rats. Journal of Ethnopharmacology, 123(3), 464-9. https://doi.org/10.1016/j.jep.2009.03.024
Alam S, et al. Antiulcer Activity of Methanolic Extract of Momordica Charantia L. in Rats. J Ethnopharmacol. 2009 Jun 25;123(3):464-9. PubMed PMID: 19501279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcer activity of methanolic extract of Momordica charantia L. in rats. AU - Alam,Samsul, AU - Asad,Mohammed, AU - Asdaq,Syed Mohammed Basheeruddin, AU - Prasad,V Satya, Y1 - 2009/03/26/ PY - 2008/07/31/received PY - 2009/03/05/revised PY - 2009/03/13/accepted PY - 2009/6/9/entrez PY - 2009/6/9/pubmed PY - 2009/10/9/medline SP - 464 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 123 IS - 3 N2 - AIM OF THE STUDY: Momordica charantia L. (Cucurbitaceae) commonly known as 'bitter gourd' is a multi purpose herb cultivated in different parts of the world for its edible fruits. The objective of the present study was to evaluate the effect of standardized methanolic extract of Momordica charantia L. fruits on gastric and duodenal ulcers. MATERIALS AND METHODS: The effect was evaluated in acetic acid induced chronic gastric ulcer, pylorus ligation induced gastric ulcer, ethanol induced gastric ulcer, stress induced gastric ulcer, indomethacin induced gastric ulcer and cysteamine induced duodenal ulcer model. The extract was administered orally at two different doses of 100 mg/kg and 500 mg/kg. RESULTS: The healing of acetic acid induced gastric ulcer was increased by both doses of the extract. In pylorus-ligated rats, the extract showed significant decrease in ulcer index, total acidity, free acidity and pepsin content and an increase in gastric mucosal content. The extract also reduced the ulcer index in stress induced, ethanol induced and indomethacin induced gastric ulcers and cysteamine induced duodenal ulcer. CONCLUSION: The methanolic extract of Momordica charantia L. fruit increases healing of gastric ulcer and also prevents development of gastric ulcers and duodenal ulcers in rats. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19501279/Antiulcer_activity_of_methanolic_extract_of_Momordica_charantia_L__in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00161-5 DB - PRIME DP - Unbound Medicine ER -