Tags

Type your tag names separated by a space and hit enter

Sub-lethal effects of profenofos on tissue-specific antioxidative responses in a Euryhyaline fish, Oreochromis mossambicus.
Ecotoxicol Environ Saf. 2009 Sep; 72(6):1727-33.EE

Abstract

The euryhaline fish, Oreochromis mossambicus was exposed to sub-lethal concentration (30 microg/L) of profenofos (PF) for 28 days and allowed to recover for 7 days. Responses were evaluated through antioxidant enzyme activities in various tissues of fish. Glutathione-S-transferase (GST) and superoxide dismutase (SOD) activities showed transient increases in gill, viscera and muscle, but decreased in brain. However, catalase (CAT) and glutathione reductase (GR) were inhibited in gill and viscera. Reduced glutathione (GSH) levels were depleted in all the tissues and a significant induction in lipid peroxidation (LPO) was observed. Significant recovery in all the studied parameters was noticed at the end of recuperation period. The enhanced LPO in the present study suggests that reactive oxygen species (ROS)-induced oxidative damage could be one of the main toxic effect of PF. The increased LPO and alterations in the antioxidant defense system can be used as biomarkers in the pesticide-contaminated aquatic streams.

Authors+Show Affiliations

Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19501401

Citation

Kavitha, P, and J Venkateswara Rao. "Sub-lethal Effects of Profenofos On Tissue-specific Antioxidative Responses in a Euryhyaline Fish, Oreochromis Mossambicus." Ecotoxicology and Environmental Safety, vol. 72, no. 6, 2009, pp. 1727-33.
Kavitha P, Venkateswara Rao J. Sub-lethal effects of profenofos on tissue-specific antioxidative responses in a Euryhyaline fish, Oreochromis mossambicus. Ecotoxicol Environ Saf. 2009;72(6):1727-33.
Kavitha, P., & Venkateswara Rao, J. (2009). Sub-lethal effects of profenofos on tissue-specific antioxidative responses in a Euryhyaline fish, Oreochromis mossambicus. Ecotoxicology and Environmental Safety, 72(6), 1727-33. https://doi.org/10.1016/j.ecoenv.2009.05.010
Kavitha P, Venkateswara Rao J. Sub-lethal Effects of Profenofos On Tissue-specific Antioxidative Responses in a Euryhyaline Fish, Oreochromis Mossambicus. Ecotoxicol Environ Saf. 2009;72(6):1727-33. PubMed PMID: 19501401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sub-lethal effects of profenofos on tissue-specific antioxidative responses in a Euryhyaline fish, Oreochromis mossambicus. AU - Kavitha,P, AU - Venkateswara Rao,J, Y1 - 2009/06/05/ PY - 2009/02/13/received PY - 2009/04/30/revised PY - 2009/05/17/accepted PY - 2009/6/9/entrez PY - 2009/6/9/pubmed PY - 2009/10/1/medline SP - 1727 EP - 33 JF - Ecotoxicology and environmental safety JO - Ecotoxicol. Environ. Saf. VL - 72 IS - 6 N2 - The euryhaline fish, Oreochromis mossambicus was exposed to sub-lethal concentration (30 microg/L) of profenofos (PF) for 28 days and allowed to recover for 7 days. Responses were evaluated through antioxidant enzyme activities in various tissues of fish. Glutathione-S-transferase (GST) and superoxide dismutase (SOD) activities showed transient increases in gill, viscera and muscle, but decreased in brain. However, catalase (CAT) and glutathione reductase (GR) were inhibited in gill and viscera. Reduced glutathione (GSH) levels were depleted in all the tissues and a significant induction in lipid peroxidation (LPO) was observed. Significant recovery in all the studied parameters was noticed at the end of recuperation period. The enhanced LPO in the present study suggests that reactive oxygen species (ROS)-induced oxidative damage could be one of the main toxic effect of PF. The increased LPO and alterations in the antioxidant defense system can be used as biomarkers in the pesticide-contaminated aquatic streams. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/19501401/Sub_lethal_effects_of_profenofos_on_tissue_specific_antioxidative_responses_in_a_Euryhyaline_fish_Oreochromis_mossambicus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(09)00125-0 DB - PRIME DP - Unbound Medicine ER -