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Comparative aspects of implantation.
Reproduction. 2009 Aug; 138(2):195-209.R

Abstract

Uterine receptivity to implantation of blastocysts in mammals includes hatching from zona pellucida, precontact with uterine luminal (LE) and superficial glandular (sGE) epithelia and orientation of blastocyst, apposition between trophectoderm and uterine LE and sGE, adhesion of trophectoderm to uterine LE/sGE, and, in some species, limited or extensive invasion into the endometrial stroma and induction of decidualization of stromal cells. These peri-implantation events are prerequisites for pregnancy recognition signaling, implantation, and placentation required for fetal-placental growth and development through the remainder of pregnancy. Although there is a range of strategies for implantation in mammals, a common feature is the requirement for progesterone (P(4)) to downregulate expression of its receptors in uterine epithelia and P(4) prior to implantation events. P(4) then mediates its effects via growth factors expressed by stromal cells in most species; however, uterine luminal epithelium may express a growth factor in response to P(4) and/or estrogens in species with a true epitheliochorial placenta. There is also compelling evidence that uterine receptivity to implantation involves temporal and cell-specific expression of interferon (IFN)-stimulated genes that may be induced directly by an IFN or induced by P(4) and stimulated by an IFN. These genes have many roles including nutrient transport, cellular remodeling, angiogenesis and relaxation of vascular tissues, cell proliferation and migration, establishment of an antiviral state, and protection of conceptus tissues from challenges by the maternal immune cells.

Authors+Show Affiliations

Department of Animal Science Veterinary Integrative Biosciences, Texas A&M University, 2471 TAMU, College Station, TX 77843-2471, USA. fbazer@cvm.tamu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

19502456

Citation

Bazer, Fuller W., et al. "Comparative Aspects of Implantation." Reproduction (Cambridge, England), vol. 138, no. 2, 2009, pp. 195-209.
Bazer FW, Spencer TE, Johnson GA, et al. Comparative aspects of implantation. Reproduction. 2009;138(2):195-209.
Bazer, F. W., Spencer, T. E., Johnson, G. A., Burghardt, R. C., & Wu, G. (2009). Comparative aspects of implantation. Reproduction (Cambridge, England), 138(2), 195-209. https://doi.org/10.1530/REP-09-0158
Bazer FW, et al. Comparative Aspects of Implantation. Reproduction. 2009;138(2):195-209. PubMed PMID: 19502456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative aspects of implantation. AU - Bazer,Fuller W, AU - Spencer,Thomas E, AU - Johnson,Greg A, AU - Burghardt,Robert C, AU - Wu,Guoyao, Y1 - 2009/06/05/ PY - 2009/6/9/entrez PY - 2009/6/9/pubmed PY - 2009/9/11/medline SP - 195 EP - 209 JF - Reproduction (Cambridge, England) JO - Reproduction VL - 138 IS - 2 N2 - Uterine receptivity to implantation of blastocysts in mammals includes hatching from zona pellucida, precontact with uterine luminal (LE) and superficial glandular (sGE) epithelia and orientation of blastocyst, apposition between trophectoderm and uterine LE and sGE, adhesion of trophectoderm to uterine LE/sGE, and, in some species, limited or extensive invasion into the endometrial stroma and induction of decidualization of stromal cells. These peri-implantation events are prerequisites for pregnancy recognition signaling, implantation, and placentation required for fetal-placental growth and development through the remainder of pregnancy. Although there is a range of strategies for implantation in mammals, a common feature is the requirement for progesterone (P(4)) to downregulate expression of its receptors in uterine epithelia and P(4) prior to implantation events. P(4) then mediates its effects via growth factors expressed by stromal cells in most species; however, uterine luminal epithelium may express a growth factor in response to P(4) and/or estrogens in species with a true epitheliochorial placenta. There is also compelling evidence that uterine receptivity to implantation involves temporal and cell-specific expression of interferon (IFN)-stimulated genes that may be induced directly by an IFN or induced by P(4) and stimulated by an IFN. These genes have many roles including nutrient transport, cellular remodeling, angiogenesis and relaxation of vascular tissues, cell proliferation and migration, establishment of an antiviral state, and protection of conceptus tissues from challenges by the maternal immune cells. SN - 1741-7899 UR - https://www.unboundmedicine.com/medline/citation/19502456/Comparative_aspects_of_implantation_ L2 - https://rep.bioscientifica.com/doi/10.1530/REP-09-0158 DB - PRIME DP - Unbound Medicine ER -