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Fine needle aspiration of breast lesions in women aged 30 and under.
Acta Cytol. 1991 Nov-Dec; 35(6):687-94.AC

Abstract

Fine needle aspiration (FNA) biopsies of 1,598 breast masses were performed between 1983 and 1989, and of them, 48 were from women aged 30 and under for whom a cytologic diagnosis was made by FNA and histologic follow-up was available. In 37 (77%) of the cases, both the cytologic and histologic diagnoses were benign. Fibroadenoma (20/37) and fibrocystic changes (14/37) were the most common benign lesions aspirated. Eight (17%) FNAs showed cytologic atypia. Four of these atypical lesions proved to be benign (two fibroadenomas, two fibrocystic changes). Epithelial proliferation in fibroadenomas and fibrocystic changes and cellular stroma in a fibroadenoma mimicking phylloides tumor were the causes of atypia in these biopsies. Four of the eight atypical lesions were shown to be carcinoma at biopsy (three infiltrating duct, one atypical medullary). Low cellularity, epithelial cohesiveness mimicking a fibroadenoma and background lactational changes in a pregnant patient were the causes of the atypical, rather than unequivocally malignant, diagnoses in these cases. In three patients (6%), a diagnosis of carcinoma was made by FNA and confirmed histologically (all were infiltrating duct carcinoma). Although most breast masses in women aged 30 and under are benign, cytologic atypia in a breast fine needle aspirate in this age group warrants a surgical biopsy. Clinical follow-up alone may be appropriate for young women with clinically nonsuspicious breast masses without cytologic atypia.

Authors+Show Affiliations

Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1950316

Citation

Maygarden, S J., et al. "Fine Needle Aspiration of Breast Lesions in Women Aged 30 and Under." Acta Cytologica, vol. 35, no. 6, 1991, pp. 687-94.
Maygarden SJ, McCall JB, Frable WJ. Fine needle aspiration of breast lesions in women aged 30 and under. Acta Cytol. 1991;35(6):687-94.
Maygarden, S. J., McCall, J. B., & Frable, W. J. (1991). Fine needle aspiration of breast lesions in women aged 30 and under. Acta Cytologica, 35(6), 687-94.
Maygarden SJ, McCall JB, Frable WJ. Fine Needle Aspiration of Breast Lesions in Women Aged 30 and Under. Acta Cytol. 1991 Nov-Dec;35(6):687-94. PubMed PMID: 1950316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fine needle aspiration of breast lesions in women aged 30 and under. AU - Maygarden,S J, AU - McCall,J B, AU - Frable,W J, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 687 EP - 94 JF - Acta cytologica JO - Acta Cytol VL - 35 IS - 6 N2 - Fine needle aspiration (FNA) biopsies of 1,598 breast masses were performed between 1983 and 1989, and of them, 48 were from women aged 30 and under for whom a cytologic diagnosis was made by FNA and histologic follow-up was available. In 37 (77%) of the cases, both the cytologic and histologic diagnoses were benign. Fibroadenoma (20/37) and fibrocystic changes (14/37) were the most common benign lesions aspirated. Eight (17%) FNAs showed cytologic atypia. Four of these atypical lesions proved to be benign (two fibroadenomas, two fibrocystic changes). Epithelial proliferation in fibroadenomas and fibrocystic changes and cellular stroma in a fibroadenoma mimicking phylloides tumor were the causes of atypia in these biopsies. Four of the eight atypical lesions were shown to be carcinoma at biopsy (three infiltrating duct, one atypical medullary). Low cellularity, epithelial cohesiveness mimicking a fibroadenoma and background lactational changes in a pregnant patient were the causes of the atypical, rather than unequivocally malignant, diagnoses in these cases. In three patients (6%), a diagnosis of carcinoma was made by FNA and confirmed histologically (all were infiltrating duct carcinoma). Although most breast masses in women aged 30 and under are benign, cytologic atypia in a breast fine needle aspirate in this age group warrants a surgical biopsy. Clinical follow-up alone may be appropriate for young women with clinically nonsuspicious breast masses without cytologic atypia. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/1950316/Fine_needle_aspiration_of_breast_lesions_in_women_aged_30_and_under_ L2 - https://medlineplus.gov/breastdiseases.html DB - PRIME DP - Unbound Medicine ER -
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