Tags

Type your tag names separated by a space and hit enter

Ototoxic effect of potassium canrenoate on the guinea pig cochlea.
Acta Otolaryngol. 1991; 111(4):719-27.AO

Abstract

Potassium canrenoate (PC) is a diuretic with antialdosterone action, reducing the reabsorption of sodium in the efferent renal tubules. This drug has been reported to damage only the marginal cells of the stria vascularis in the cochlea. The perilymphatic space of the guinea pig cochlea was perfused with an artificial perilymph containing 5 x 10(-3) M potassium canrenoate. Following the onset of perfusion, the endocochlear dc potential (EP) gradually declined to around 10 mV but did not become negative even when the perfusion was continued. A similar decrease in EP was observed in kanamycin-deafened guinea pigs. When the respirator was turned off and perfusion discontinued, a large negative EP appeared during 5 min of anoxia in normal guinea pigs but not in the kanamycin-deafened guinea pigs. The decreased EP recovered to preanoxic level after resumption of ventilation. The cochlear microphonics (CM) also gradually declined in parallel with the EP. The summating potential (SP) showed only a minor change. The potassium ion activity in the endolymph decreased slightly but the sodium ion activity remained unchanged during perfusion. These findings suggest that the main target of the PC is the cells of the stria vascularis.

Authors+Show Affiliations

Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1950534

Citation

Komune, S, et al. "Ototoxic Effect of Potassium Canrenoate On the Guinea Pig Cochlea." Acta Oto-laryngologica, vol. 111, no. 4, 1991, pp. 719-27.
Komune S, Wakizono S, Nakagawa T, et al. Ototoxic effect of potassium canrenoate on the guinea pig cochlea. Acta Otolaryngol. 1991;111(4):719-27.
Komune, S., Wakizono, S., Nakagawa, T., Kimituki, T., Hisashi, K., & Uemura, T. (1991). Ototoxic effect of potassium canrenoate on the guinea pig cochlea. Acta Oto-laryngologica, 111(4), 719-27.
Komune S, et al. Ototoxic Effect of Potassium Canrenoate On the Guinea Pig Cochlea. Acta Otolaryngol. 1991;111(4):719-27. PubMed PMID: 1950534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ototoxic effect of potassium canrenoate on the guinea pig cochlea. AU - Komune,S, AU - Wakizono,S, AU - Nakagawa,T, AU - Kimituki,T, AU - Hisashi,K, AU - Uemura,T, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 719 EP - 27 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 111 IS - 4 N2 - Potassium canrenoate (PC) is a diuretic with antialdosterone action, reducing the reabsorption of sodium in the efferent renal tubules. This drug has been reported to damage only the marginal cells of the stria vascularis in the cochlea. The perilymphatic space of the guinea pig cochlea was perfused with an artificial perilymph containing 5 x 10(-3) M potassium canrenoate. Following the onset of perfusion, the endocochlear dc potential (EP) gradually declined to around 10 mV but did not become negative even when the perfusion was continued. A similar decrease in EP was observed in kanamycin-deafened guinea pigs. When the respirator was turned off and perfusion discontinued, a large negative EP appeared during 5 min of anoxia in normal guinea pigs but not in the kanamycin-deafened guinea pigs. The decreased EP recovered to preanoxic level after resumption of ventilation. The cochlear microphonics (CM) also gradually declined in parallel with the EP. The summating potential (SP) showed only a minor change. The potassium ion activity in the endolymph decreased slightly but the sodium ion activity remained unchanged during perfusion. These findings suggest that the main target of the PC is the cells of the stria vascularis. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/1950534/Ototoxic_effect_of_potassium_canrenoate_on_the_guinea_pig_cochlea_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016489109138404 DB - PRIME DP - Unbound Medicine ER -