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Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction.
Br J Nutr. 2009 Nov; 102(9):1355-61.BJ

Abstract

The risk of CHD has been linked to n-3 and trans-fatty acids. The purpose of the present study was to evaluate the hypothesis that lower n-3 fatty acids and higher trans-fatty acids in erythrocytes are associated with an increased risk of acute non-fatal myocardial infarction (MI), and that fatty acid profiles can discriminate MI cases from controls. Fifty cases with acute non-fatal MI and fifty age- and sex-matched controls without MI were recruited. The Omega-3 Index (the sum of EPA and DHA in erythrocytes) was significantly lower in cases than controls (9.57 (SEM 0.28) v. 11.81 (SEM 0.35) %; P < 0.001), while total trans-fatty acids were significantly higher (1.01 (SEM 0.04) v. 0.56 (SEM 0.03) %; P < 0.001). The Omega-3 Index was associated with decreased risk of MI (OR 0.08 (95 % CI 0.02, 0.38); P = 0.001), while total trans-fatty acids were associated with an increased risk of MI (OR 72.67 (95 % CI 6.68, 790.74); P < 0.001). The area under the receiver operating characteristic curve of fatty acid profiles was larger than that for traditional risk factors, suggesting that fatty acid profiles make a higher contribution to the discrimination of MI cases from controls compared with modified Framingham risk factors. In conclusion, a higher Omega-3 Index and lower trans-fatty acids in erythrocytes are associated with a decreased risk of MI. Furthermore, fatty acid profiles improve discrimination of acute non-fatal MI compared with established risk factors.

Authors+Show Affiliations

Department of Food and Nutrition, Hanyang University, Seoul, South Korea. yongsoon@hanyang.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19505347

Citation

Park, Yongsoon, et al. "Erythrocyte Fatty Acid Profiles Can Predict Acute Non-fatal Myocardial Infarction." The British Journal of Nutrition, vol. 102, no. 9, 2009, pp. 1355-61.
Park Y, Lim J, Lee J, et al. Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction. Br J Nutr. 2009;102(9):1355-61.
Park, Y., Lim, J., Lee, J., & Kim, S. G. (2009). Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction. The British Journal of Nutrition, 102(9), 1355-61. https://doi.org/10.1017/S0007114509990298
Park Y, et al. Erythrocyte Fatty Acid Profiles Can Predict Acute Non-fatal Myocardial Infarction. Br J Nutr. 2009;102(9):1355-61. PubMed PMID: 19505347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction. AU - Park,Yongsoon, AU - Lim,Jeehyun, AU - Lee,Jaeung, AU - Kim,Soon-gil, Y1 - 2009/06/09/ PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/12/22/medline SP - 1355 EP - 61 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 102 IS - 9 N2 - The risk of CHD has been linked to n-3 and trans-fatty acids. The purpose of the present study was to evaluate the hypothesis that lower n-3 fatty acids and higher trans-fatty acids in erythrocytes are associated with an increased risk of acute non-fatal myocardial infarction (MI), and that fatty acid profiles can discriminate MI cases from controls. Fifty cases with acute non-fatal MI and fifty age- and sex-matched controls without MI were recruited. The Omega-3 Index (the sum of EPA and DHA in erythrocytes) was significantly lower in cases than controls (9.57 (SEM 0.28) v. 11.81 (SEM 0.35) %; P < 0.001), while total trans-fatty acids were significantly higher (1.01 (SEM 0.04) v. 0.56 (SEM 0.03) %; P < 0.001). The Omega-3 Index was associated with decreased risk of MI (OR 0.08 (95 % CI 0.02, 0.38); P = 0.001), while total trans-fatty acids were associated with an increased risk of MI (OR 72.67 (95 % CI 6.68, 790.74); P < 0.001). The area under the receiver operating characteristic curve of fatty acid profiles was larger than that for traditional risk factors, suggesting that fatty acid profiles make a higher contribution to the discrimination of MI cases from controls compared with modified Framingham risk factors. In conclusion, a higher Omega-3 Index and lower trans-fatty acids in erythrocytes are associated with a decreased risk of MI. Furthermore, fatty acid profiles improve discrimination of acute non-fatal MI compared with established risk factors. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19505347/Erythrocyte_fatty_acid_profiles_can_predict_acute_non_fatal_myocardial_infarction_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509990298/type/journal_article DB - PRIME DP - Unbound Medicine ER -