Tags

Type your tag names separated by a space and hit enter

Effects of a depressor on cochlear blood flow and perilymphatic oxygen tension.
Acta Otolaryngol. 1991; 111(4):743-9.AO

Abstract

To clarify the characteristics of the blood circulation in the cochlea, we investigated the relationship between cochlear blood flow and perilymphatic oxygen tension in guinea pigs with trimetaphan camsilate induced hypotension. Cochlear blood flow was measured by laser Doppler flowmetry, and perilymphatic oxygen tension by a polarographic method. Cochlear blood flow generally paralleled systemic blood pressure, while perilymphatic oxygen tension showed a slower response to the decrease of systemic blood pressure. Although there were individual differences in the changes of systemic blood pressure, cochlear blood flow and perilymphatic oxygen tension, they were found to be dose dependent. Since hypotension induced by trimetaphan camsilate is fairly reproducible in the dose range of this experiment, this drug can be used as a ganglion blocking agent in experiments on cochlear blood flow and perilymphatic oxygen tension during systemic hypotension. The change of perilymphatic oxygen tension with a slower response could be considered to be a factor in the homeostasis in the inner ear fluid.

Authors+Show Affiliations

Department of Otolaryngology, Osaka Medical College, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1950537

Citation

Kawakami, M, et al. "Effects of a Depressor On Cochlear Blood Flow and Perilymphatic Oxygen Tension." Acta Oto-laryngologica, vol. 111, no. 4, 1991, pp. 743-9.
Kawakami M, Makimoto K, Fukuse S, et al. Effects of a depressor on cochlear blood flow and perilymphatic oxygen tension. Acta Otolaryngol. 1991;111(4):743-9.
Kawakami, M., Makimoto, K., Fukuse, S., & Takahashi, H. (1991). Effects of a depressor on cochlear blood flow and perilymphatic oxygen tension. Acta Oto-laryngologica, 111(4), 743-9.
Kawakami M, et al. Effects of a Depressor On Cochlear Blood Flow and Perilymphatic Oxygen Tension. Acta Otolaryngol. 1991;111(4):743-9. PubMed PMID: 1950537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a depressor on cochlear blood flow and perilymphatic oxygen tension. AU - Kawakami,M, AU - Makimoto,K, AU - Fukuse,S, AU - Takahashi,H, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 743 EP - 9 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 111 IS - 4 N2 - To clarify the characteristics of the blood circulation in the cochlea, we investigated the relationship between cochlear blood flow and perilymphatic oxygen tension in guinea pigs with trimetaphan camsilate induced hypotension. Cochlear blood flow was measured by laser Doppler flowmetry, and perilymphatic oxygen tension by a polarographic method. Cochlear blood flow generally paralleled systemic blood pressure, while perilymphatic oxygen tension showed a slower response to the decrease of systemic blood pressure. Although there were individual differences in the changes of systemic blood pressure, cochlear blood flow and perilymphatic oxygen tension, they were found to be dose dependent. Since hypotension induced by trimetaphan camsilate is fairly reproducible in the dose range of this experiment, this drug can be used as a ganglion blocking agent in experiments on cochlear blood flow and perilymphatic oxygen tension during systemic hypotension. The change of perilymphatic oxygen tension with a slower response could be considered to be a factor in the homeostasis in the inner ear fluid. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/1950537/Effects_of_a_depressor_on_cochlear_blood_flow_and_perilymphatic_oxygen_tension_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016489109138407 DB - PRIME DP - Unbound Medicine ER -