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Hepatoprotective effect of chrysin on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats.
J Pharm Pharmacol 2009; 61(6):809-17JP

Abstract

OBJECTIVES

To evaluate the effect of chrysin, a natural, biologically active compound extracted from many plants, honey and propolis, on the tissue and circulatory antioxidant status, and lipid peroxidation in ethanol-induced hepatotoxicity in rats.

METHODS

Rats were divided into four groups. Groups 1 and 2 received isocaloric glucose. Groups 3 and 4 received 20% ethanol, equivalent to 5 g/kg bodyweight every day. Groups 2 and 4 received chrysin (20 mg/kg bodyweight) dissolved in 0.5% dimethylsulfoxide.

KEY FINDINGS

The results showed significantly elevated levels of tissue and circulatory thiobarbituric acid reactive substances, conjugated dienes and lipid hydroperoxides, and significantly lowered enzymic and non-enzymic antioxidant activity of superoxide dismutase, catalase and glutathione-related enzymes such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase, reduced glutathione, vitamin C and vitamin E in ethanol-treated rats compared with the control. Chrysin administration to rats with ethanol-induced liver injury significantly decreased the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes, and significantly elevated the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and the levels of reduced glutathione, vitamin C and vitamin E in the tissues and circulation compared with those of the unsupplemented ethanol-treated rats. The histological changes observed in the liver and kidney correlated with the biochemical findings.

CONCLUSIONS

Chrysin offers protection against free radical-mediated oxidative stress in rats with ethanol-induced liver injury.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19505373

Citation

Sathiavelu, Jayanthi, et al. "Hepatoprotective Effect of Chrysin On Prooxidant-antioxidant Status During Ethanol-induced Toxicity in Female Albino Rats." The Journal of Pharmacy and Pharmacology, vol. 61, no. 6, 2009, pp. 809-17.
Sathiavelu J, Senapathy GJ, Devaraj R, et al. Hepatoprotective effect of chrysin on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats. J Pharm Pharmacol. 2009;61(6):809-17.
Sathiavelu, J., Senapathy, G. J., Devaraj, R., & Namasivayam, N. (2009). Hepatoprotective effect of chrysin on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats. The Journal of Pharmacy and Pharmacology, 61(6), pp. 809-17. doi:10.1211/jpp/61.06.0015.
Sathiavelu J, et al. Hepatoprotective Effect of Chrysin On Prooxidant-antioxidant Status During Ethanol-induced Toxicity in Female Albino Rats. J Pharm Pharmacol. 2009;61(6):809-17. PubMed PMID: 19505373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective effect of chrysin on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats. AU - Sathiavelu,Jayanthi, AU - Senapathy,Giftson Jebakkan, AU - Devaraj,Rajkumar, AU - Namasivayam,Nalini, PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/8/19/medline SP - 809 EP - 17 JF - The Journal of pharmacy and pharmacology JO - J. Pharm. Pharmacol. VL - 61 IS - 6 N2 - OBJECTIVES: To evaluate the effect of chrysin, a natural, biologically active compound extracted from many plants, honey and propolis, on the tissue and circulatory antioxidant status, and lipid peroxidation in ethanol-induced hepatotoxicity in rats. METHODS: Rats were divided into four groups. Groups 1 and 2 received isocaloric glucose. Groups 3 and 4 received 20% ethanol, equivalent to 5 g/kg bodyweight every day. Groups 2 and 4 received chrysin (20 mg/kg bodyweight) dissolved in 0.5% dimethylsulfoxide. KEY FINDINGS: The results showed significantly elevated levels of tissue and circulatory thiobarbituric acid reactive substances, conjugated dienes and lipid hydroperoxides, and significantly lowered enzymic and non-enzymic antioxidant activity of superoxide dismutase, catalase and glutathione-related enzymes such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase, reduced glutathione, vitamin C and vitamin E in ethanol-treated rats compared with the control. Chrysin administration to rats with ethanol-induced liver injury significantly decreased the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes, and significantly elevated the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and the levels of reduced glutathione, vitamin C and vitamin E in the tissues and circulation compared with those of the unsupplemented ethanol-treated rats. The histological changes observed in the liver and kidney correlated with the biochemical findings. CONCLUSIONS: Chrysin offers protection against free radical-mediated oxidative stress in rats with ethanol-induced liver injury. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/19505373/Hepatoprotective_effect_of_chrysin_on_prooxidant_antioxidant_status_during_ethanol_induced_toxicity_in_female_albino_rats_ L2 - https://doi.org/10.1211/jpp/61.06.0015 DB - PRIME DP - Unbound Medicine ER -