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A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa.
J Ethnopharmacol. 2009 Sep 07; 125(2):330-6.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Juniperus L. (Cupressaceae) species have been used to various inflammatory and infectious diseases such as bronchitis, colds, cough, fungal infections, hemorrhoids, gynecological diseases, and wounds in Turkish folk medicine.

AIM OF THE STUDY

To evaluate this traditional information, anti-inflammatory and antinociceptive activities of the methanolic and aqueous extracts prepared from different parts (stem, fruit and leaves) of the five Turkish taxa under Juniperus section of the gender; J. drupacea, J. communis var. communis, J. communis var. saxatilis, J. oxycedrus subsp. oxycedrus, and J. oxycedrus subsp. macrocarpa growing were investigated.

METHODS

For the anti-inflammatory activity, carrageenan-induced and PGE(2)-induced hind paw edema models, and for the antinociceptive activity p-benzoquinone-induced writhing and hot plate tests in mice were employed.

RESULTS

The methanolic extracts of fruit and leaves from J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis exhibited notable inhibition in carrageenan-induced edema model at a dose of 100mg/kg. The same extracts also displayed significant activity against PGE(2)-induced edema model. While, the remaining extracts were found inactive against these edema models. A similar activity pattern was observed against p-benzoquinone-induced abdominal constriction test without inducing any gastric damage or apparent acute toxicity, whereas all extracts were inactive in hot plate test.

CONCLUSION

The experimental data demonstrated that J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis displayed remarkable anti-inflammatory and antinociceptive activities; however, further studies are warranted to define and isolate the active anti-inflammatory and antinociceptive components from these active species which may yield safe and effective agents to be used in the treatment of inflammatory disorders.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19505566

Citation

Akkol, Esra Küpeli, et al. "A Comparative Study On the Antinociceptive and Anti-inflammatory Activities of Five Juniperus Taxa." Journal of Ethnopharmacology, vol. 125, no. 2, 2009, pp. 330-6.
Akkol EK, Güvenç A, Yesilada E. A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa. J Ethnopharmacol. 2009;125(2):330-6.
Akkol, E. K., Güvenç, A., & Yesilada, E. (2009). A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa. Journal of Ethnopharmacology, 125(2), 330-6. https://doi.org/10.1016/j.jep.2009.05.031
Akkol EK, Güvenç A, Yesilada E. A Comparative Study On the Antinociceptive and Anti-inflammatory Activities of Five Juniperus Taxa. J Ethnopharmacol. 2009 Sep 7;125(2):330-6. PubMed PMID: 19505566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa. AU - Akkol,Esra Küpeli, AU - Güvenç,Ayşegül, AU - Yesilada,Erdem, Y1 - 2009/06/06/ PY - 2009/01/28/received PY - 2009/05/04/revised PY - 2009/05/28/accepted PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/12/16/medline SP - 330 EP - 6 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 125 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Juniperus L. (Cupressaceae) species have been used to various inflammatory and infectious diseases such as bronchitis, colds, cough, fungal infections, hemorrhoids, gynecological diseases, and wounds in Turkish folk medicine. AIM OF THE STUDY: To evaluate this traditional information, anti-inflammatory and antinociceptive activities of the methanolic and aqueous extracts prepared from different parts (stem, fruit and leaves) of the five Turkish taxa under Juniperus section of the gender; J. drupacea, J. communis var. communis, J. communis var. saxatilis, J. oxycedrus subsp. oxycedrus, and J. oxycedrus subsp. macrocarpa growing were investigated. METHODS: For the anti-inflammatory activity, carrageenan-induced and PGE(2)-induced hind paw edema models, and for the antinociceptive activity p-benzoquinone-induced writhing and hot plate tests in mice were employed. RESULTS: The methanolic extracts of fruit and leaves from J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis exhibited notable inhibition in carrageenan-induced edema model at a dose of 100mg/kg. The same extracts also displayed significant activity against PGE(2)-induced edema model. While, the remaining extracts were found inactive against these edema models. A similar activity pattern was observed against p-benzoquinone-induced abdominal constriction test without inducing any gastric damage or apparent acute toxicity, whereas all extracts were inactive in hot plate test. CONCLUSION: The experimental data demonstrated that J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis displayed remarkable anti-inflammatory and antinociceptive activities; however, further studies are warranted to define and isolate the active anti-inflammatory and antinociceptive components from these active species which may yield safe and effective agents to be used in the treatment of inflammatory disorders. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19505566/A_comparative_study_on_the_antinociceptive_and_anti_inflammatory_activities_of_five_Juniperus_taxa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00343-2 DB - PRIME DP - Unbound Medicine ER -