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Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men.
Gut. 2009 Oct; 58(10):1419-25.Gut

Abstract

OBJECTIVES

We performed a prospective study to determine whether weight gain predicts future ultrasonographically detected fatty liver (USFL) in a lean adult population.

METHODS

Among 15,347 Korean male workers, aged 30-59 years, who participated in a health check-up programme in 2002, a USFL-free cohort of 4246 non-diabetic men was followed until September 2007. Alcohol consumption was assessed by a questionnaire. Weight change for each subject was calculated as the difference between baseline and subsequent measurements. Biochemical tests for liver and metabolic function were done. The primary outcome was ultrasound-diagnosed fatty liver. A standard Cox proportional hazards model and time-dependent Cox model were performed.

RESULTS

During 16,829.7 person-years of follow-up, 622 participants developed USFL. After adjusting for age, the period from visit 1 to visit 2, BMI, HDL-C, triglyceride, uric acid, alanine aminotransferase, and HOMA-IR, the risk for USFL increased with increasing quartiles of weight change (p for trend <0.001). This association remained significant when weight change and covariates, except age and the period from visit 1 to visit 2, were modelled as time-dependent variables. Subjects in the fourth quartile (weight gain > or =2.3 kg) were at significantly elevated risk for USFL (adjusted hazard ratio (aHR), 1.26; 95% CI, 1.01 to 1.58). These associations did not change, even in normal weight men with a baseline BMI between 18.5 and 22.9 kg/m(2) (n = 2186).

CONCLUSION

Weight gain per se appears to increase the risk for developing USFL. Thus, avoiding weight gain, even among lean adult individuals, can be helpful in preventing this disease.

Authors+Show Affiliations

Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, 108 Pyung dong, Jongro-Gu, Seoul, Korea 110-746.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19505882

Citation

Chang, Y, et al. "Weight Gain Within the Normal Weight Range Predicts Ultrasonographically Detected Fatty Liver in Healthy Korean Men." Gut, vol. 58, no. 10, 2009, pp. 1419-25.
Chang Y, Ryu S, Sung E, et al. Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men. Gut. 2009;58(10):1419-25.
Chang, Y., Ryu, S., Sung, E., Woo, H. Y., Cho, S. I., Yoo, S. H., Ahn, H. Y., & Choi, N. K. (2009). Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men. Gut, 58(10), 1419-25. https://doi.org/10.1136/gut.2008.161885
Chang Y, et al. Weight Gain Within the Normal Weight Range Predicts Ultrasonographically Detected Fatty Liver in Healthy Korean Men. Gut. 2009;58(10):1419-25. PubMed PMID: 19505882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men. AU - Chang,Y, AU - Ryu,S, AU - Sung,E, AU - Woo,H-Y, AU - Cho,S-I, AU - Yoo,S-H, AU - Ahn,H-Y, AU - Choi,N-K, Y1 - 2009/06/07/ PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/11/17/medline SP - 1419 EP - 25 JF - Gut JO - Gut VL - 58 IS - 10 N2 - OBJECTIVES: We performed a prospective study to determine whether weight gain predicts future ultrasonographically detected fatty liver (USFL) in a lean adult population. METHODS: Among 15,347 Korean male workers, aged 30-59 years, who participated in a health check-up programme in 2002, a USFL-free cohort of 4246 non-diabetic men was followed until September 2007. Alcohol consumption was assessed by a questionnaire. Weight change for each subject was calculated as the difference between baseline and subsequent measurements. Biochemical tests for liver and metabolic function were done. The primary outcome was ultrasound-diagnosed fatty liver. A standard Cox proportional hazards model and time-dependent Cox model were performed. RESULTS: During 16,829.7 person-years of follow-up, 622 participants developed USFL. After adjusting for age, the period from visit 1 to visit 2, BMI, HDL-C, triglyceride, uric acid, alanine aminotransferase, and HOMA-IR, the risk for USFL increased with increasing quartiles of weight change (p for trend <0.001). This association remained significant when weight change and covariates, except age and the period from visit 1 to visit 2, were modelled as time-dependent variables. Subjects in the fourth quartile (weight gain > or =2.3 kg) were at significantly elevated risk for USFL (adjusted hazard ratio (aHR), 1.26; 95% CI, 1.01 to 1.58). These associations did not change, even in normal weight men with a baseline BMI between 18.5 and 22.9 kg/m(2) (n = 2186). CONCLUSION: Weight gain per se appears to increase the risk for developing USFL. Thus, avoiding weight gain, even among lean adult individuals, can be helpful in preventing this disease. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/19505882/Weight_gain_within_the_normal_weight_range_predicts_ultrasonographically_detected_fatty_liver_in_healthy_Korean_men_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&amp;pmid=19505882 DB - PRIME DP - Unbound Medicine ER -