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Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status.
Cancer Epidemiol Biomarkers Prev. 2009 Jun; 18(6):1746-53.CE

Abstract

In spite of their anticarcinogenic potential, the effect of coffee and green tea consumption on the risk of liver cancer has not been clarified prospectively in consideration of hepatitis C (HCV) and B virus (HBV) infection. We examined whether coffee and green tea consumption was associated with a reduced risk of liver cancer by hepatitis virus infection status in the Japan Public Health Center-Based Prospective Study Cohort II. A total of 18,815 subjects ages 40 to 69 years participating in a questionnaire and health checkup survey in 1993 to 1994 were followed for the incidence of liver cancer through 2006. A total of 110 cases of liver cancer were newly documented. Hazard ratios for coffee and green tea consumption categories were calculated with a Cox proportional hazards model. Compared with almost never drinkers, increased coffee consumption was associated with a reduced risk of liver cancer in all subjects (hazard ratio for <1, 1-2, and >or=3 cups/d; P(trend) = 0.67, 0.49, 0.54, and 0.025). A similar risk tendency was observed in those with either or both HCV and HBV infection. In contrast, no association was observed between green tea consumption and the risk of liver cancer in all subjects. Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. mnminoue@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19505908

Citation

Inoue, Manami, et al. "Effect of Coffee and Green Tea Consumption On the Risk of Liver Cancer: Cohort Analysis By Hepatitis Virus Infection Status." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 6, 2009, pp. 1746-53.
Inoue M, Kurahashi N, Iwasaki M, et al. Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1746-53.
Inoue, M., Kurahashi, N., Iwasaki, M., Shimazu, T., Tanaka, Y., Mizokami, M., & Tsugane, S. (2009). Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(6), 1746-53. https://doi.org/10.1158/1055-9965.EPI-08-0923
Inoue M, et al. Effect of Coffee and Green Tea Consumption On the Risk of Liver Cancer: Cohort Analysis By Hepatitis Virus Infection Status. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1746-53. PubMed PMID: 19505908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status. AU - Inoue,Manami, AU - Kurahashi,Norie, AU - Iwasaki,Motoki, AU - Shimazu,Taichi, AU - Tanaka,Yasuhito, AU - Mizokami,Masashi, AU - Tsugane,Shoichiro, AU - ,, PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/9/9/medline SP - 1746 EP - 53 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 18 IS - 6 N2 - In spite of their anticarcinogenic potential, the effect of coffee and green tea consumption on the risk of liver cancer has not been clarified prospectively in consideration of hepatitis C (HCV) and B virus (HBV) infection. We examined whether coffee and green tea consumption was associated with a reduced risk of liver cancer by hepatitis virus infection status in the Japan Public Health Center-Based Prospective Study Cohort II. A total of 18,815 subjects ages 40 to 69 years participating in a questionnaire and health checkup survey in 1993 to 1994 were followed for the incidence of liver cancer through 2006. A total of 110 cases of liver cancer were newly documented. Hazard ratios for coffee and green tea consumption categories were calculated with a Cox proportional hazards model. Compared with almost never drinkers, increased coffee consumption was associated with a reduced risk of liver cancer in all subjects (hazard ratio for <1, 1-2, and >or=3 cups/d; P(trend) = 0.67, 0.49, 0.54, and 0.025). A similar risk tendency was observed in those with either or both HCV and HBV infection. In contrast, no association was observed between green tea consumption and the risk of liver cancer in all subjects. Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/19505908/Effect_of_coffee_and_green_tea_consumption_on_the_risk_of_liver_cancer:_cohort_analysis_by_hepatitis_virus_infection_status_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=19505908 DB - PRIME DP - Unbound Medicine ER -