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Dietary acrylamide intake and prostate cancer risk in a prospective cohort of Swedish men.
Cancer Epidemiol Biomarkers Prev 2009; 18(6):1939-41CE

Abstract

BACKGROUND

Acrylamide is a probable human carcinogen that can be formed in foods prepared at high temperatures. Whereas evidence indicates that acrylamide causes cancer in laboratory animals, epidemiologic data on dietary acrylamide intake in relation to cancer risk are limited and mainly null. We examined the association between dietary acrylamide intake and risk of prostate cancer in a cohort of men.

METHODS

The Cohort of Swedish Men is a population-based prospective study of 45,306 men who were cancer-free and completed a food frequency questionnaire at enrollment in 1997. Cox proportional hazards models were used to estimate relative risks adjusted for potential confounders.

RESULTS

During a mean follow-up of 9.1 years, we ascertained 2,696 incident cases of prostate cancer. We observed no association between acrylamide intake and risk of prostate cancer. Compared with the lowest quintile of acrylamide intake (mean, 23.7 microg/d), the multivariable relative risks (95% confidence interval) for the highest quintile (mean, 49.8 microg/d) were 0.88 (0.70-1.09) for total prostate cancer, 1.07 (0.87-1.32) for localized prostate cancer (n = 1,088), and 0.98 (0.78-1.22) for advanced prostate cancer (n = 951).

CONCLUSIONS

Results from this prospective study provide no evidence that dietary acrylamide in amounts typically consumed by Swedish men is associated with risk of prostate cancer

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19505926

Citation

Larsson, Susanna C., et al. "Dietary Acrylamide Intake and Prostate Cancer Risk in a Prospective Cohort of Swedish Men." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 6, 2009, pp. 1939-41.
Larsson SC, Akesson A, Wolk A. Dietary acrylamide intake and prostate cancer risk in a prospective cohort of Swedish men. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1939-41.
Larsson, S. C., Akesson, A., & Wolk, A. (2009). Dietary acrylamide intake and prostate cancer risk in a prospective cohort of Swedish men. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(6), pp. 1939-41. doi:10.1158/1055-9965.EPI-09-0280.
Larsson SC, Akesson A, Wolk A. Dietary Acrylamide Intake and Prostate Cancer Risk in a Prospective Cohort of Swedish Men. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1939-41. PubMed PMID: 19505926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary acrylamide intake and prostate cancer risk in a prospective cohort of Swedish men. AU - Larsson,Susanna C, AU - Akesson,Agneta, AU - Wolk,Alicja, PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/9/9/medline SP - 1939 EP - 41 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 18 IS - 6 N2 - BACKGROUND: Acrylamide is a probable human carcinogen that can be formed in foods prepared at high temperatures. Whereas evidence indicates that acrylamide causes cancer in laboratory animals, epidemiologic data on dietary acrylamide intake in relation to cancer risk are limited and mainly null. We examined the association between dietary acrylamide intake and risk of prostate cancer in a cohort of men. METHODS: The Cohort of Swedish Men is a population-based prospective study of 45,306 men who were cancer-free and completed a food frequency questionnaire at enrollment in 1997. Cox proportional hazards models were used to estimate relative risks adjusted for potential confounders. RESULTS: During a mean follow-up of 9.1 years, we ascertained 2,696 incident cases of prostate cancer. We observed no association between acrylamide intake and risk of prostate cancer. Compared with the lowest quintile of acrylamide intake (mean, 23.7 microg/d), the multivariable relative risks (95% confidence interval) for the highest quintile (mean, 49.8 microg/d) were 0.88 (0.70-1.09) for total prostate cancer, 1.07 (0.87-1.32) for localized prostate cancer (n = 1,088), and 0.98 (0.78-1.22) for advanced prostate cancer (n = 951). CONCLUSIONS: Results from this prospective study provide no evidence that dietary acrylamide in amounts typically consumed by Swedish men is associated with risk of prostate cancer SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/19505926/Dietary_acrylamide_intake_and_prostate_cancer_risk_in_a_prospective_cohort_of_Swedish_men_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19505926 DB - PRIME DP - Unbound Medicine ER -