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Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis.
Arch Intern Med 2009; 169(11):1035-45AI

Abstract

BACKGROUND

Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are associated with alcohol consumption and cigarette smoking. The etiology of RAP and CP is complex, and effects of alcohol and smoking may be limited to specific patient subsets. We examined the current prevalence of alcohol use and smoking and their association with RAP and CP in patients evaluated at US referral centers.

METHODS

The North American Pancreatitis Study 2, a multicenter consortium of 20 US centers, prospectively enrolled 540 patients with CP, 460 patients with RAP, and 695 controls from 2000 to 2006. Using self-reported monthly alcohol consumption during the maximum lifetime drinking period, we classified subjects by drinking status: abstainer, light drinker (< or =0.5 drink per day), moderate drinker (women, >0.5 to 1 drink per day; men, >0.5 to 2 drinks per day), heavy drinker (women, >1 to <5 drinks per day; men, >2 to <5 drinks per day), or very heavy drinker (> or =5 drinks per day for both sexes). Smoking was classified as never, past, or current and was quantified (packs per day and pack-years).

RESULTS

Overall, participants' mean (SD) age was 49.7 (15.4) years; 87.5% were white, and 56.5% were women. Approximately one-fourth of both controls and patients were lifetime abstainers. The prevalence of very heavy drinking among men and women was 38.4% and 11.0% for CP, 16.9% and 5.5% for RAP, and 10.0% and 3.6% for controls. Compared with abstaining and light drinking, very heavy drinking was significantly associated with CP (odds ratio, 3.10; 95% confidence interval, 1.87-5.14) after controlling for age, sex, smoking status, and body mass index. Cigarette smoking was an independent, dose-dependent risk factor for CP and RAP.

CONCLUSIONS

Very heavy alcohol consumption and smoking are independent risks for CP. A minority of patients with pancreatitis currently seen at US referral centers report very heavy drinking.

Authors+Show Affiliations

Department of Medicine, University of Pittsburgh, 3708 Fifth Ave., Pittsburgh, PA 15213, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19506173

Citation

Yadav, Dhiraj, et al. "Alcohol Consumption, Cigarette Smoking, and the Risk of Recurrent Acute and Chronic Pancreatitis." Archives of Internal Medicine, vol. 169, no. 11, 2009, pp. 1035-45.
Yadav D, Hawes RH, Brand RE, et al. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med. 2009;169(11):1035-45.
Yadav, D., Hawes, R. H., Brand, R. E., Anderson, M. A., Money, M. E., Banks, P. A., ... Whitcomb, D. C. (2009). Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Archives of Internal Medicine, 169(11), pp. 1035-45. doi:10.1001/archinternmed.2009.125.
Yadav D, et al. Alcohol Consumption, Cigarette Smoking, and the Risk of Recurrent Acute and Chronic Pancreatitis. Arch Intern Med. 2009 Jun 8;169(11):1035-45. PubMed PMID: 19506173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. AU - Yadav,Dhiraj, AU - Hawes,Robert H, AU - Brand,Randall E, AU - Anderson,Michelle A, AU - Money,Mary E, AU - Banks,Peter A, AU - Bishop,Michele D, AU - Baillie,John, AU - Sherman,Stuart, AU - DiSario,James, AU - Burton,Frank R, AU - Gardner,Timothy B, AU - Amann,Stephen T, AU - Gelrud,Andres, AU - Lawrence,Christopher, AU - Elinoff,Beth, AU - Greer,Julia B, AU - O'Connell,Michael, AU - Barmada,M Michael, AU - Slivka,Adam, AU - Whitcomb,David C, AU - ,, PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/7/22/medline SP - 1035 EP - 45 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 169 IS - 11 N2 - BACKGROUND: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are associated with alcohol consumption and cigarette smoking. The etiology of RAP and CP is complex, and effects of alcohol and smoking may be limited to specific patient subsets. We examined the current prevalence of alcohol use and smoking and their association with RAP and CP in patients evaluated at US referral centers. METHODS: The North American Pancreatitis Study 2, a multicenter consortium of 20 US centers, prospectively enrolled 540 patients with CP, 460 patients with RAP, and 695 controls from 2000 to 2006. Using self-reported monthly alcohol consumption during the maximum lifetime drinking period, we classified subjects by drinking status: abstainer, light drinker (< or =0.5 drink per day), moderate drinker (women, >0.5 to 1 drink per day; men, >0.5 to 2 drinks per day), heavy drinker (women, >1 to <5 drinks per day; men, >2 to <5 drinks per day), or very heavy drinker (> or =5 drinks per day for both sexes). Smoking was classified as never, past, or current and was quantified (packs per day and pack-years). RESULTS: Overall, participants' mean (SD) age was 49.7 (15.4) years; 87.5% were white, and 56.5% were women. Approximately one-fourth of both controls and patients were lifetime abstainers. The prevalence of very heavy drinking among men and women was 38.4% and 11.0% for CP, 16.9% and 5.5% for RAP, and 10.0% and 3.6% for controls. Compared with abstaining and light drinking, very heavy drinking was significantly associated with CP (odds ratio, 3.10; 95% confidence interval, 1.87-5.14) after controlling for age, sex, smoking status, and body mass index. Cigarette smoking was an independent, dose-dependent risk factor for CP and RAP. CONCLUSIONS: Very heavy alcohol consumption and smoking are independent risks for CP. A minority of patients with pancreatitis currently seen at US referral centers report very heavy drinking. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/19506173/Alcohol_consumption_cigarette_smoking_and_the_risk_of_recurrent_acute_and_chronic_pancreatitis_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2009.125 DB - PRIME DP - Unbound Medicine ER -