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The effect of a plant-based low-carbohydrate ("Eco-Atkins") diet on body weight and blood lipid concentrations in hyperlipidemic subjects.
Arch Intern Med 2009; 169(11):1046-54AI

Abstract

BACKGROUND

Low-carbohydrate, high-animal protein diets, which are advocated for weight loss, may not promote the desired reduction in low-density lipoprotein cholesterol (LDL-C) concentration. The effect of exchanging the animal proteins and fats for those of vegetable origin has not been tested. Our objective was to determine the effect on weight loss and LDL-C concentration of a low-carbohydrate diet high in vegetable proteins from gluten, soy, nuts, fruits, vegetables, cereals, and vegetable oils compared with a high-carbohydrate diet based on low-fat dairy and whole grain products.

METHODS

A total of 47 overweight hyperlipidemic men and women consumed either (1) a low-carbohydrate (26% of total calories), high-vegetable protein (31% from gluten, soy, nuts, fruit, vegetables, and cereals), and vegetable oil (43%) plant-based diet or (2) a high-carbohydrate lacto-ovo vegetarian diet (58% carbohydrate, 16% protein, and 25% fat) for 4 weeks each in a parallel study design. The study food was provided at 60% of calorie requirements.

RESULTS

Of the 47 subjects, 44 (94%) (test, n = 22 [92%]; control, n = 22 [96%]) completed the study. Weight loss was similar for both diets (approximately 4.0 kg). However, reductions in LDL-C concentration and total cholesterol-HDL-C and apolipoprotein B-apolipoprotein AI ratios were greater for the low-carbohydrate compared with the high-carbohydrate diet (-8.1% [P = .002], -8.7% [P = .004], and -9.6% [P = .001], respectively). Reductions in systolic and diastolic blood pressure were also seen (-1.9% [P = .052] and -2.4% [P = .02], respectively).

CONCLUSION

A low-carbohydrate plant-based diet has lipid-lowering advantages over a high-carbohydrate, low-fat weight-loss diet in improving heart disease risk factors not seen with conventional low-fat diets with animal products.

Authors+Show Affiliations

Clinical Nutrition and Risk Factor Modification Center, St Michael's Hospital, 61 Queen St. E, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19506174

Citation

Jenkins, David J A., et al. "The Effect of a Plant-based Low-carbohydrate ("Eco-Atkins") Diet On Body Weight and Blood Lipid Concentrations in Hyperlipidemic Subjects." Archives of Internal Medicine, vol. 169, no. 11, 2009, pp. 1046-54.
Jenkins DJ, Wong JM, Kendall CW, et al. The effect of a plant-based low-carbohydrate ("Eco-Atkins") diet on body weight and blood lipid concentrations in hyperlipidemic subjects. Arch Intern Med. 2009;169(11):1046-54.
Jenkins, D. J., Wong, J. M., Kendall, C. W., Esfahani, A., Ng, V. W., Leong, T. C., ... Singer, W. (2009). The effect of a plant-based low-carbohydrate ("Eco-Atkins") diet on body weight and blood lipid concentrations in hyperlipidemic subjects. Archives of Internal Medicine, 169(11), pp. 1046-54. doi:10.1001/archinternmed.2009.115.
Jenkins DJ, et al. The Effect of a Plant-based Low-carbohydrate ("Eco-Atkins") Diet On Body Weight and Blood Lipid Concentrations in Hyperlipidemic Subjects. Arch Intern Med. 2009 Jun 8;169(11):1046-54. PubMed PMID: 19506174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of a plant-based low-carbohydrate ("Eco-Atkins") diet on body weight and blood lipid concentrations in hyperlipidemic subjects. AU - Jenkins,David J A, AU - Wong,Julia M W, AU - Kendall,Cyril W C, AU - Esfahani,Amin, AU - Ng,Vivian W Y, AU - Leong,Tracy C K, AU - Faulkner,Dorothea A, AU - Vidgen,Ed, AU - Greaves,Kathryn A, AU - Paul,Gregory, AU - Singer,William, PY - 2009/6/10/entrez PY - 2009/6/10/pubmed PY - 2009/7/22/medline SP - 1046 EP - 54 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 169 IS - 11 N2 - BACKGROUND: Low-carbohydrate, high-animal protein diets, which are advocated for weight loss, may not promote the desired reduction in low-density lipoprotein cholesterol (LDL-C) concentration. The effect of exchanging the animal proteins and fats for those of vegetable origin has not been tested. Our objective was to determine the effect on weight loss and LDL-C concentration of a low-carbohydrate diet high in vegetable proteins from gluten, soy, nuts, fruits, vegetables, cereals, and vegetable oils compared with a high-carbohydrate diet based on low-fat dairy and whole grain products. METHODS: A total of 47 overweight hyperlipidemic men and women consumed either (1) a low-carbohydrate (26% of total calories), high-vegetable protein (31% from gluten, soy, nuts, fruit, vegetables, and cereals), and vegetable oil (43%) plant-based diet or (2) a high-carbohydrate lacto-ovo vegetarian diet (58% carbohydrate, 16% protein, and 25% fat) for 4 weeks each in a parallel study design. The study food was provided at 60% of calorie requirements. RESULTS: Of the 47 subjects, 44 (94%) (test, n = 22 [92%]; control, n = 22 [96%]) completed the study. Weight loss was similar for both diets (approximately 4.0 kg). However, reductions in LDL-C concentration and total cholesterol-HDL-C and apolipoprotein B-apolipoprotein AI ratios were greater for the low-carbohydrate compared with the high-carbohydrate diet (-8.1% [P = .002], -8.7% [P = .004], and -9.6% [P = .001], respectively). Reductions in systolic and diastolic blood pressure were also seen (-1.9% [P = .052] and -2.4% [P = .02], respectively). CONCLUSION: A low-carbohydrate plant-based diet has lipid-lowering advantages over a high-carbohydrate, low-fat weight-loss diet in improving heart disease risk factors not seen with conventional low-fat diets with animal products. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/19506174/The_effect_of_a_plant_based_low_carbohydrate__"Eco_Atkins"__diet_on_body_weight_and_blood_lipid_concentrations_in_hyperlipidemic_subjects_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2009.115 DB - PRIME DP - Unbound Medicine ER -