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Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma.
Biochem Biophys Res Commun. 2009 Aug 14; 386(1):181-5.BB

Abstract

Interleukin (IL)-33 is a recently described member of the IL-1 family and has been shown to induce production of T helper type 2 cytokines. In this study, an anti-IL-33 antibody was evaluated against pulmonary inflammation in mice sensitized and challenged with ovalbumin. The anti-IL-33 or a control antibody (150 microg/mouse) was given intraperitoneally as five doses before the sensitization and antigen challenge. Treatment with anti-IL-33 significantly reduced serum IgE secretion, the numbers of eosinophils and lymphocytes, and concentrations of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid compared with administration of a control antibody. Histological examination of lung tissue demonstrated that anti-IL-33 significantly inhibited allergen-induced lung eosinophilic inflammation and mucus hypersecretion. Our data demonstrate for the first time that anti-IL-33 antibody can prevent the development of asthma in a mouse model and indicate that blockade of IL-33 may be a new therapeutic strategy for allergic asthma.

Authors+Show Affiliations

Institute of Inflammation and Immune Diseases, Shantou University Medical College, Shantou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19508862

Citation

Liu, Xiaojin, et al. "Anti-IL-33 Antibody Treatment Inhibits Airway Inflammation in a Murine Model of Allergic Asthma." Biochemical and Biophysical Research Communications, vol. 386, no. 1, 2009, pp. 181-5.
Liu X, Li M, Wu Y, et al. Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma. Biochem Biophys Res Commun. 2009;386(1):181-5.
Liu, X., Li, M., Wu, Y., Zhou, Y., Zeng, L., & Huang, T. (2009). Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma. Biochemical and Biophysical Research Communications, 386(1), 181-5. https://doi.org/10.1016/j.bbrc.2009.06.008
Liu X, et al. Anti-IL-33 Antibody Treatment Inhibits Airway Inflammation in a Murine Model of Allergic Asthma. Biochem Biophys Res Commun. 2009 Aug 14;386(1):181-5. PubMed PMID: 19508862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma. AU - Liu,Xiaojin, AU - Li,Mingcai, AU - Wu,Yan, AU - Zhou,Yanchun, AU - Zeng,Liangming, AU - Huang,Tian, Y1 - 2009/06/07/ PY - 2009/05/05/received PY - 2009/06/03/accepted PY - 2009/6/11/entrez PY - 2009/6/11/pubmed PY - 2009/7/28/medline SP - 181 EP - 5 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 386 IS - 1 N2 - Interleukin (IL)-33 is a recently described member of the IL-1 family and has been shown to induce production of T helper type 2 cytokines. In this study, an anti-IL-33 antibody was evaluated against pulmonary inflammation in mice sensitized and challenged with ovalbumin. The anti-IL-33 or a control antibody (150 microg/mouse) was given intraperitoneally as five doses before the sensitization and antigen challenge. Treatment with anti-IL-33 significantly reduced serum IgE secretion, the numbers of eosinophils and lymphocytes, and concentrations of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid compared with administration of a control antibody. Histological examination of lung tissue demonstrated that anti-IL-33 significantly inhibited allergen-induced lung eosinophilic inflammation and mucus hypersecretion. Our data demonstrate for the first time that anti-IL-33 antibody can prevent the development of asthma in a mouse model and indicate that blockade of IL-33 may be a new therapeutic strategy for allergic asthma. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/19508862/Anti_IL_33_antibody_treatment_inhibits_airway_inflammation_in_a_murine_model_of_allergic_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(09)01131-0 DB - PRIME DP - Unbound Medicine ER -