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Formulation and characterization of an oily-based system for oral delivery of insulin.
Eur J Pharm Biopharm. 2009 Oct; 73(2):269-79.EJ

Abstract

The present work explored the possibility of formulating an oral insulin delivery system by combining the advantages of nanoencapsulation and the use of oily vehicle. The parameters affecting formulation such as association efficiency were characterized. The preparation was evaluated for its chemical, physical and biological stability. The preparation has unimodal particle size distribution with a mean diameter of 108+/-9 nm. Insulin was protected from gastric enzymes by incorporation into lipid-based formulation. The results of RP HPLC and ELISA indicated that insulin was able to withstand the preparation procedure. Insulin in the preparations was stable for a period of one month at storage temperatures of 4 and 25 degrees C. It was also biologically active and stable as demonstrated by the remarkable reduction of blood glucose levels of the STZ-diabetic rats after oral administration of the preparation. Moreover, hypoglycemic effect of nanoparticles administered orally was sustained for a longer period of time compared to the subcutaneous injection. These results clearly evidenced the ability of the nanoparticles to enhance the pharmacological response of insulin when given orally and could be used to deliver other peptides.

Authors+Show Affiliations

Department of Pharmaceutics, Gezira University, Medani, Sudan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19508890

Citation

Elsayed, Amani, et al. "Formulation and Characterization of an Oily-based System for Oral Delivery of Insulin." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 73, no. 2, 2009, pp. 269-79.
Elsayed A, Remawi MA, Qinna N, et al. Formulation and characterization of an oily-based system for oral delivery of insulin. Eur J Pharm Biopharm. 2009;73(2):269-79.
Elsayed, A., Remawi, M. A., Qinna, N., Farouk, A., & Badwan, A. (2009). Formulation and characterization of an oily-based system for oral delivery of insulin. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 73(2), 269-79. https://doi.org/10.1016/j.ejpb.2009.06.004
Elsayed A, et al. Formulation and Characterization of an Oily-based System for Oral Delivery of Insulin. Eur J Pharm Biopharm. 2009;73(2):269-79. PubMed PMID: 19508890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and characterization of an oily-based system for oral delivery of insulin. AU - Elsayed,Amani, AU - Remawi,Mayyas Al, AU - Qinna,Nidal, AU - Farouk,Asim, AU - Badwan,Adnan, Y1 - 2009/06/07/ PY - 2008/09/22/received PY - 2009/05/31/revised PY - 2009/06/02/accepted PY - 2009/6/11/entrez PY - 2009/6/11/pubmed PY - 2009/12/16/medline SP - 269 EP - 79 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 73 IS - 2 N2 - The present work explored the possibility of formulating an oral insulin delivery system by combining the advantages of nanoencapsulation and the use of oily vehicle. The parameters affecting formulation such as association efficiency were characterized. The preparation was evaluated for its chemical, physical and biological stability. The preparation has unimodal particle size distribution with a mean diameter of 108+/-9 nm. Insulin was protected from gastric enzymes by incorporation into lipid-based formulation. The results of RP HPLC and ELISA indicated that insulin was able to withstand the preparation procedure. Insulin in the preparations was stable for a period of one month at storage temperatures of 4 and 25 degrees C. It was also biologically active and stable as demonstrated by the remarkable reduction of blood glucose levels of the STZ-diabetic rats after oral administration of the preparation. Moreover, hypoglycemic effect of nanoparticles administered orally was sustained for a longer period of time compared to the subcutaneous injection. These results clearly evidenced the ability of the nanoparticles to enhance the pharmacological response of insulin when given orally and could be used to deliver other peptides. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/19508890/Formulation_and_characterization_of_an_oily_based_system_for_oral_delivery_of_insulin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(09)00168-4 DB - PRIME DP - Unbound Medicine ER -