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Penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforations.
Cornea 2009; 28(6):631-7C

Abstract

PURPOSE

To report the outcome of penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforation.

METHODS

In this retrospective consecutive case series, 15 eyes of 15 patients with eccentric corneal perforations underwent small-diameter penetrating keratoplasties with glycerin-cryopreserved grafts. The corneal grafts used in this study were 2.5-4.5 mm in size and preserved at -20 degrees C in pure glycerin for 6 months to 5 years. The donors were secured with 6-8 sutures that spared the visual axis. The follow-up ranged from 7 to 36 months. Clarity of the grafts was observed, and changes in visual acuity and keratometric astigmatism were analyzed.

RESULTS

: Global integrity was achieved in all eyes. All grafts remained clear at the end of the follow-up time. No immune rejection was detected. No complicated cataract or secondary glaucoma was developed. The uncorrected visual acuity improved from preoperative 20/2000 approximately 20/60 to postoperative 20/40 approximately 20/20, and the best-corrected visual acuity after surgery was 20/30 or better. The mean value of keratometric astigmatism was 2.47 +/- 0.78 diopters postoperatively.

CONCLUSIONS

Small-diameter penetrating keratoplasty seems to be effective in treating various eccentric corneal perforations. Glycerin-cryopreserved donors may be a suitable alternative to fresh material for this technique, which solves the problem of shortage in supplying corneas and can be used in an emergency.

Authors+Show Affiliations

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19512909

Citation

Shi, Weiyun, et al. "Penetrating Keratoplasty With Small-diameter and Glycerin-cryopreserved Grafts for Eccentric Corneal Perforations." Cornea, vol. 28, no. 6, 2009, pp. 631-7.
Shi W, Liu M, Gao H, et al. Penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforations. Cornea. 2009;28(6):631-7.
Shi, W., Liu, M., Gao, H., Li, S., Wang, T., & Xie, L. (2009). Penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforations. Cornea, 28(6), pp. 631-7. doi:10.1097/ICO.0b013e318191b857.
Shi W, et al. Penetrating Keratoplasty With Small-diameter and Glycerin-cryopreserved Grafts for Eccentric Corneal Perforations. Cornea. 2009;28(6):631-7. PubMed PMID: 19512909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforations. AU - Shi,Weiyun, AU - Liu,Mingna, AU - Gao,Hua, AU - Li,Suxia, AU - Wang,Ting, AU - Xie,Lixin, PY - 2009/6/11/entrez PY - 2009/6/11/pubmed PY - 2009/9/9/medline SP - 631 EP - 7 JF - Cornea JO - Cornea VL - 28 IS - 6 N2 - PURPOSE: To report the outcome of penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforation. METHODS: In this retrospective consecutive case series, 15 eyes of 15 patients with eccentric corneal perforations underwent small-diameter penetrating keratoplasties with glycerin-cryopreserved grafts. The corneal grafts used in this study were 2.5-4.5 mm in size and preserved at -20 degrees C in pure glycerin for 6 months to 5 years. The donors were secured with 6-8 sutures that spared the visual axis. The follow-up ranged from 7 to 36 months. Clarity of the grafts was observed, and changes in visual acuity and keratometric astigmatism were analyzed. RESULTS: : Global integrity was achieved in all eyes. All grafts remained clear at the end of the follow-up time. No immune rejection was detected. No complicated cataract or secondary glaucoma was developed. The uncorrected visual acuity improved from preoperative 20/2000 approximately 20/60 to postoperative 20/40 approximately 20/20, and the best-corrected visual acuity after surgery was 20/30 or better. The mean value of keratometric astigmatism was 2.47 +/- 0.78 diopters postoperatively. CONCLUSIONS: Small-diameter penetrating keratoplasty seems to be effective in treating various eccentric corneal perforations. Glycerin-cryopreserved donors may be a suitable alternative to fresh material for this technique, which solves the problem of shortage in supplying corneas and can be used in an emergency. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/19512909/Penetrating_keratoplasty_with_small_diameter_and_glycerin_cryopreserved_grafts_for_eccentric_corneal_perforations_ L2 - http://Insights.ovid.com/pubmed?pmid=19512909 DB - PRIME DP - Unbound Medicine ER -