Tags

Type your tag names separated by a space and hit enter

Fusarium keratitis in Mexico.
Cornea 2009; 28(6):626-30C

Abstract

PURPOSE

To describe the clinical characteristics, diagnosis, treatment, and visual outcome of 61 cases of Fusarium keratitis in Mexico.

METHODS

Retrospective, comparative study of 61 patients with clinically and culture-confirmed Fusarium keratitis, who were attended at an eye hospital in Mexico City from 1981 to 2001.

RESULTS

Fusarium solani was the main causal agent in 83.6% of cases. Trauma history was observed in 57.4% and a history of agricultural activity in 34.4%. Signs were redness (100%), epithelial defects (98.3%), superficial corneal ulcer (95.1%), anterior chamber inflammation (91.8%), and satellite infiltrates (75.4%). In 50% of cases, the treatment was topical ketoconazole 2%; in 34.2% of cases, additional topical antifungal preparations were used. A total of 77% of patients improved and 23% worsened. Conjunctival flap was indicated in 4 of 61 patients (6.5%), and 14 of 61 patients (23%) underwent penetrating keratoplasty. Two of 61 patients were treated with tectonic keratoplasty. Evisceration surgeries were practiced in 14 of 61 patients (22.9%). The final visual acuity after medical or medical/surgical therapy, was no light perception (NLP) in 19 patients (33.33%), light perception (LP) to hand movements (HM) in 18 patients (31.57%), 20/400 to 20/200 in 1 patient (1.75%), 20/150 to 20/60 in 5 patients (8.77%), and 20/40 to 20/20 in 14 patients (24.56%). Four patients were lost to follow-up.

CONCLUSIONS

Fusarium is the most common cause of fungal keratitis in Mexico. Most cases (43/54, 79.6%) improved with topical antifungal therapy (either monotherapy or combined). We suggest surgical therapy with conjunctival flap or penetrating keratoplasty in advanced cases, when there has been poor response to medical therapy or a very low final visual acuity.

Authors+Show Affiliations

From Cornea Service and the Laboratory of Microbiology, Dr. Luis Sánchez Bulnes Hospital, Asociación para Evitar la Ceguera en México, Coyoacán, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19512910

Citation

Pérez-Balbuena, Ana Lilia, et al. "Fusarium Keratitis in Mexico." Cornea, vol. 28, no. 6, 2009, pp. 626-30.
Pérez-Balbuena AL, Vanzzini-Rosano V, Valadéz-Virgen Jde J, et al. Fusarium keratitis in Mexico. Cornea. 2009;28(6):626-30.
Pérez-Balbuena, A. L., Vanzzini-Rosano, V., Valadéz-Virgen, J. d. e. . J., & Campos-Möller, X. (2009). Fusarium keratitis in Mexico. Cornea, 28(6), pp. 626-30. doi:10.1097/ICO.0b013e31819bc2ea.
Pérez-Balbuena AL, et al. Fusarium Keratitis in Mexico. Cornea. 2009;28(6):626-30. PubMed PMID: 19512910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fusarium keratitis in Mexico. AU - Pérez-Balbuena,Ana Lilia, AU - Vanzzini-Rosano,Virginia, AU - Valadéz-Virgen,José de Jesús, AU - Campos-Möller,Xavier, PY - 2009/6/11/entrez PY - 2009/6/11/pubmed PY - 2009/9/9/medline SP - 626 EP - 30 JF - Cornea JO - Cornea VL - 28 IS - 6 N2 - PURPOSE: To describe the clinical characteristics, diagnosis, treatment, and visual outcome of 61 cases of Fusarium keratitis in Mexico. METHODS: Retrospective, comparative study of 61 patients with clinically and culture-confirmed Fusarium keratitis, who were attended at an eye hospital in Mexico City from 1981 to 2001. RESULTS: Fusarium solani was the main causal agent in 83.6% of cases. Trauma history was observed in 57.4% and a history of agricultural activity in 34.4%. Signs were redness (100%), epithelial defects (98.3%), superficial corneal ulcer (95.1%), anterior chamber inflammation (91.8%), and satellite infiltrates (75.4%). In 50% of cases, the treatment was topical ketoconazole 2%; in 34.2% of cases, additional topical antifungal preparations were used. A total of 77% of patients improved and 23% worsened. Conjunctival flap was indicated in 4 of 61 patients (6.5%), and 14 of 61 patients (23%) underwent penetrating keratoplasty. Two of 61 patients were treated with tectonic keratoplasty. Evisceration surgeries were practiced in 14 of 61 patients (22.9%). The final visual acuity after medical or medical/surgical therapy, was no light perception (NLP) in 19 patients (33.33%), light perception (LP) to hand movements (HM) in 18 patients (31.57%), 20/400 to 20/200 in 1 patient (1.75%), 20/150 to 20/60 in 5 patients (8.77%), and 20/40 to 20/20 in 14 patients (24.56%). Four patients were lost to follow-up. CONCLUSIONS: Fusarium is the most common cause of fungal keratitis in Mexico. Most cases (43/54, 79.6%) improved with topical antifungal therapy (either monotherapy or combined). We suggest surgical therapy with conjunctival flap or penetrating keratoplasty in advanced cases, when there has been poor response to medical therapy or a very low final visual acuity. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/19512910/Fusarium_keratitis_in_Mexico_ L2 - http://dx.doi.org/10.1097/ICO.0b013e31819bc2ea DB - PRIME DP - Unbound Medicine ER -