Tags

Type your tag names separated by a space and hit enter

Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Br J Cancer 2009; 101(1):178-84BJ

Abstract

BACKGROUND

Epidemiological evidence on meat intake and breast cancer is inconsistent, with little research on potentially carcinogenic meat-related exposures. We investigated meat subtypes, cooking practices, meat mutagens, iron, and subsequent breast cancer risk.

METHODS

Among 52 158 women (aged 55-74 years) in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, who completed a food frequency questionnaire, 1205 invasive breast cancer cases were identified. We estimated meat mutagen and haem iron intake with databases accounting for cooking practices. Using Cox proportional hazards regression, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) within quintiles of intake.

RESULTS

Comparing the fifth to the first quintile, red meat (HR=1.23; 95% CI=1.00-1.51, P trend=0.22), the heterocyclic amine (HCA), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), (HR=1.26; 95% CI=1.03-1.55; P trend=0.12), and dietary iron (HR=1.25; 95% CI=1.02-1.52; P trend=0.03) were positively associated with breast cancer. We observed elevated, though not statistically significant, risks with processed meat, the HCA 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), mutagenic activity, iron from meat, and haem iron from meat.

CONCLUSION

In this prospective study, red meat, MeIQx, and dietary iron elevated the risk of invasive breast cancer, but there was no linear trend in the association except for dietary iron.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA. ferruccil@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

19513076

Citation

Ferrucci, L M., et al. "Intake of Meat, Meat Mutagens, and Iron and the Risk of Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial." British Journal of Cancer, vol. 101, no. 1, 2009, pp. 178-84.
Ferrucci LM, Cross AJ, Graubard BI, et al. Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Br J Cancer. 2009;101(1):178-84.
Ferrucci, L. M., Cross, A. J., Graubard, B. I., Brinton, L. A., McCarty, C. A., Ziegler, R. G., ... Sinha, R. (2009). Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. British Journal of Cancer, 101(1), pp. 178-84. doi:10.1038/sj.bjc.6605118.
Ferrucci LM, et al. Intake of Meat, Meat Mutagens, and Iron and the Risk of Breast Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Br J Cancer. 2009 Jul 7;101(1):178-84. PubMed PMID: 19513076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. AU - Ferrucci,L M, AU - Cross,A J, AU - Graubard,B I, AU - Brinton,L A, AU - McCarty,C A, AU - Ziegler,R G, AU - Ma,X, AU - Mayne,S T, AU - Sinha,R, Y1 - 2009/06/09/ PY - 2009/6/11/entrez PY - 2009/6/11/pubmed PY - 2009/7/9/medline SP - 178 EP - 84 JF - British journal of cancer JO - Br. J. Cancer VL - 101 IS - 1 N2 - BACKGROUND: Epidemiological evidence on meat intake and breast cancer is inconsistent, with little research on potentially carcinogenic meat-related exposures. We investigated meat subtypes, cooking practices, meat mutagens, iron, and subsequent breast cancer risk. METHODS: Among 52 158 women (aged 55-74 years) in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, who completed a food frequency questionnaire, 1205 invasive breast cancer cases were identified. We estimated meat mutagen and haem iron intake with databases accounting for cooking practices. Using Cox proportional hazards regression, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) within quintiles of intake. RESULTS: Comparing the fifth to the first quintile, red meat (HR=1.23; 95% CI=1.00-1.51, P trend=0.22), the heterocyclic amine (HCA), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), (HR=1.26; 95% CI=1.03-1.55; P trend=0.12), and dietary iron (HR=1.25; 95% CI=1.02-1.52; P trend=0.03) were positively associated with breast cancer. We observed elevated, though not statistically significant, risks with processed meat, the HCA 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), mutagenic activity, iron from meat, and haem iron from meat. CONCLUSION: In this prospective study, red meat, MeIQx, and dietary iron elevated the risk of invasive breast cancer, but there was no linear trend in the association except for dietary iron. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/19513076/Intake_of_meat_meat_mutagens_and_iron_and_the_risk_of_breast_cancer_in_the_Prostate_Lung_Colorectal_and_Ovarian_Cancer_Screening_Trial_ L2 - http://dx.doi.org/10.1038/sj.bjc.6605118 DB - PRIME DP - Unbound Medicine ER -