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Neu Laxova syndrome in two Egyptian families.
Am J Med Genet. 1991 Oct 01; 41(1):30-1.AJ

Abstract

We report on 2 Egyptian girls from 2 families with 8 affected relatives, 4 in each family. The 2 propositae had unusual facial appearance, severe microcephaly, generalized edema, contractures of limbs, and generalized ichthyotic skin lesions. Findings in the present 2 patients were compared with those in previously reported cases of Neu Laxova syndrome. In our cases, consanguinity, affected sibs, and affected cousins were noted. Autosomal recessive inheritance and lethality are emphasized. A high frequency of the Neu Laxova syndrome in Egyptians is suspected as a result of the increased consanguinity rate.

Authors+Show Affiliations

Abdel Meguid N
Human Genetics Department, National Research Center, Cairo, Egypt.
Temtamy SA
No affiliation info available

MeSH

Abnormalities, MultipleConsanguinityEgyptFaceFemaleFetal Growth RetardationHumansIchthyosisInfant, NewbornJointsMaleMicrocephalyPregnancy

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1951459

Citation

Abdel Meguid, N, and S A. Temtamy. "Neu Laxova Syndrome in Two Egyptian Families." American Journal of Medical Genetics, vol. 41, no. 1, 1991, pp. 30-1.
Abdel Meguid N, Temtamy SA. Neu Laxova syndrome in two Egyptian families. Am J Med Genet. 1991;41(1):30-1.
Abdel Meguid, N., & Temtamy, S. A. (1991). Neu Laxova syndrome in two Egyptian families. American Journal of Medical Genetics, 41(1), 30-1.
Abdel Meguid N, Temtamy SA. Neu Laxova Syndrome in Two Egyptian Families. Am J Med Genet. 1991 Oct 1;41(1):30-1. PubMed PMID: 1951459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neu Laxova syndrome in two Egyptian families. AU - Abdel Meguid,N, AU - Temtamy,S A, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 30 EP - 1 JF - American journal of medical genetics JO - Am J Med Genet VL - 41 IS - 1 N2 - We report on 2 Egyptian girls from 2 families with 8 affected relatives, 4 in each family. The 2 propositae had unusual facial appearance, severe microcephaly, generalized edema, contractures of limbs, and generalized ichthyotic skin lesions. Findings in the present 2 patients were compared with those in previously reported cases of Neu Laxova syndrome. In our cases, consanguinity, affected sibs, and affected cousins were noted. Autosomal recessive inheritance and lethality are emphasized. A high frequency of the Neu Laxova syndrome in Egyptians is suspected as a result of the increased consanguinity rate. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/1951459/Neu_Laxova_syndrome_in_two_Egyptian_families_ DB - PRIME DP - Unbound Medicine ER -