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What sets Bacillus anthracis apart from other Bacillus species?
Annu Rev Microbiol 2009; 63:451-76AR

Abstract

Bacillus anthracis is the cause of anthrax, and two large plasmids are essential for toxicity: pXO1, which contains the toxin genes, and pXO2, which encodes a capsule. B. anthracis forms a highly monomorphic lineage within the B. cereus group, but strains of Bacillus thuringiensis and B. cereus exist that are genetically closely related to the B. anthracis cluster. During the past five years B. cereus strains that contain the pXO1 virulence plasmid were discovered, and strains with both pXO1 and pXO2 have been isolated from great apes in Africa. Therefore, the presence of pXO1 and pXO2 no longer principally separates B. anthracis from other Bacilli. The B. anthracis lineage carries a specific mutation in the global regulator PlcR, which controls the transcription of secreted virulence factors in B. cereus and B. thuringiensis. Coevolution of the B. anthracis chromosome with its plasmids may be the basis for the successful development and uniqueness of the B. anthracis lineage.

Authors+Show Affiliations

Laboratory for Microbial Dynamics and Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo 0316, Norway. a.b.kolsto@farmasi.uio.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19514852

Citation

Kolstø, Anne-Brit, et al. "What Sets Bacillus Anthracis Apart From Other Bacillus Species?" Annual Review of Microbiology, vol. 63, 2009, pp. 451-76.
Kolstø AB, Tourasse NJ, Økstad OA. What sets Bacillus anthracis apart from other Bacillus species? Annu Rev Microbiol. 2009;63:451-76.
Kolstø, A. B., Tourasse, N. J., & Økstad, O. A. (2009). What sets Bacillus anthracis apart from other Bacillus species? Annual Review of Microbiology, 63, pp. 451-76. doi:10.1146/annurev.micro.091208.073255.
Kolstø AB, Tourasse NJ, Økstad OA. What Sets Bacillus Anthracis Apart From Other Bacillus Species. Annu Rev Microbiol. 2009;63:451-76. PubMed PMID: 19514852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What sets Bacillus anthracis apart from other Bacillus species? AU - Kolstø,Anne-Brit, AU - Tourasse,Nicolas J, AU - Økstad,Ole Andreas, PY - 2009/6/12/entrez PY - 2009/6/12/pubmed PY - 2009/10/31/medline SP - 451 EP - 76 JF - Annual review of microbiology JO - Annu. Rev. Microbiol. VL - 63 N2 - Bacillus anthracis is the cause of anthrax, and two large plasmids are essential for toxicity: pXO1, which contains the toxin genes, and pXO2, which encodes a capsule. B. anthracis forms a highly monomorphic lineage within the B. cereus group, but strains of Bacillus thuringiensis and B. cereus exist that are genetically closely related to the B. anthracis cluster. During the past five years B. cereus strains that contain the pXO1 virulence plasmid were discovered, and strains with both pXO1 and pXO2 have been isolated from great apes in Africa. Therefore, the presence of pXO1 and pXO2 no longer principally separates B. anthracis from other Bacilli. The B. anthracis lineage carries a specific mutation in the global regulator PlcR, which controls the transcription of secreted virulence factors in B. cereus and B. thuringiensis. Coevolution of the B. anthracis chromosome with its plasmids may be the basis for the successful development and uniqueness of the B. anthracis lineage. SN - 1545-3251 UR - https://www.unboundmedicine.com/medline/citation/19514852/What_sets_Bacillus_anthracis_apart_from_other_Bacillus_species L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev.micro.091208.073255?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -