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Chitosan glutamate hydrogels with local anesthetic activity for buccal application.
Drug Deliv 2009; 16(3):176-81DD

Abstract

Hydrogels for the buccal application of the anesthetic drug lidocaine hydrochloride (LDC) were prepared using chitosan glutamate (CHG), a soluble salt of chitosan, or a binary mixture of CHG and glycerin, at different weight ratios. The in vitro drug release was studied at the pH value of saliva to assess the effect of the different formulations on drug delivery. The anesthetic activity of mucoadhesive LDC-CHG hydrogels was assessed in vivo after application on the buccal mucosa, compared to commercial semisolid formulations containing the same drug. LDC-loaded hydrogels can be proposed for the symptom relief of aphthosis or other painful mouth diseases.

Authors+Show Affiliations

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, viale A. Doria, 6, Catania I-95125, Italy. r.pignatello@unict.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19514978

Citation

Pignatello, R, et al. "Chitosan Glutamate Hydrogels With Local Anesthetic Activity for Buccal Application." Drug Delivery, vol. 16, no. 3, 2009, pp. 176-81.
Pignatello R, Basile L, Puglisi G. Chitosan glutamate hydrogels with local anesthetic activity for buccal application. Drug Deliv. 2009;16(3):176-81.
Pignatello, R., Basile, L., & Puglisi, G. (2009). Chitosan glutamate hydrogels with local anesthetic activity for buccal application. Drug Delivery, 16(3), pp. 176-81. doi:10.1080/10717540902861267.
Pignatello R, Basile L, Puglisi G. Chitosan Glutamate Hydrogels With Local Anesthetic Activity for Buccal Application. Drug Deliv. 2009;16(3):176-81. PubMed PMID: 19514978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitosan glutamate hydrogels with local anesthetic activity for buccal application. AU - Pignatello,R, AU - Basile,L, AU - Puglisi,G, PY - 2009/6/12/entrez PY - 2009/6/12/pubmed PY - 2009/9/26/medline SP - 176 EP - 81 JF - Drug delivery JO - Drug Deliv VL - 16 IS - 3 N2 - Hydrogels for the buccal application of the anesthetic drug lidocaine hydrochloride (LDC) were prepared using chitosan glutamate (CHG), a soluble salt of chitosan, or a binary mixture of CHG and glycerin, at different weight ratios. The in vitro drug release was studied at the pH value of saliva to assess the effect of the different formulations on drug delivery. The anesthetic activity of mucoadhesive LDC-CHG hydrogels was assessed in vivo after application on the buccal mucosa, compared to commercial semisolid formulations containing the same drug. LDC-loaded hydrogels can be proposed for the symptom relief of aphthosis or other painful mouth diseases. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/19514978/Chitosan_glutamate_hydrogels_with_local_anesthetic_activity_for_buccal_application_ L2 - http://www.tandfonline.com/doi/full/10.1080/10717540902861267 DB - PRIME DP - Unbound Medicine ER -