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Dietary pattern, the metabolic syndrome, and left ventricular mass and systolic function: the Multi-Ethnic Study of Atherosclerosis.
Am J Clin Nutr 2009; 90(2):362-8AJ

Abstract

BACKGROUND

Little is known about the relations between dietary patterns, metabolic dysfunction, and left ventricular (LV) function.

OBJECTIVE

The objective was to examine associations of dietary patterns with LV mass and function and to explore the potential role of metabolic dysfunction in the association between diet and LV function.

DESIGN

Dietary patterns that maximally explained the variation in metabolic syndrome (MetSyn) components were derived by using reduced rank regression (RRR). LV mass, stroke volume, and LV ejection fraction (LVEF) were measured by magnetic resonance imaging. Associations between dietary pattern and LV indexes were analyzed cross-sectionally.

RESULTS

A total of 4601 participants aged 45-84 y and free of clinical cardiovascular disease were studied. The primary RRR dietary pattern score was positively correlated with intake of foods with a high glycemic index, high-fat meats, cheeses, and processed foods and negatively correlated with low intakes of vegetables, soy, fruit, green and black tea, low-fat dairy desserts, seeds and nuts, and fish. Multivariate analyses showed that each 1-unit increase in the RRR dietary pattern score was associated with a 0.32-g/m(2) increase in LV mass/body surface area, a 0.43-mL/m(2) decrease in stroke volume/body surface area, and a 0.21% decrease in LVEF. The associations of the RRR dietary pattern score with LV mass and stroke indexes were attenuated and became nonsignificant after adjustment for all MetSyn components (P > 0.05).

CONCLUSIONS

The results suggest that the RRR dietary pattern is significantly associated with unfavorable LV function, and this association might be mediated by metabolic dysfunction. Given the cross-sectional nature of our study, these results must be confirmed with the use of longitudinal data.

Authors+Show Affiliations

Department of Epidemiology & Biostatistics, Drexel University School of Public Health, Philadelphia, PA 19102, USA. longjian.liu@drexel.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19515735

Citation

Liu, Longjian, et al. "Dietary Pattern, the Metabolic Syndrome, and Left Ventricular Mass and Systolic Function: the Multi-Ethnic Study of Atherosclerosis." The American Journal of Clinical Nutrition, vol. 90, no. 2, 2009, pp. 362-8.
Liu L, Nettleton JA, Bertoni AG, et al. Dietary pattern, the metabolic syndrome, and left ventricular mass and systolic function: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2009;90(2):362-8.
Liu, L., Nettleton, J. A., Bertoni, A. G., Bluemke, D. A., Lima, J. A., & Szklo, M. (2009). Dietary pattern, the metabolic syndrome, and left ventricular mass and systolic function: the Multi-Ethnic Study of Atherosclerosis. The American Journal of Clinical Nutrition, 90(2), pp. 362-8. doi:10.3945/ajcn.2009.27538.
Liu L, et al. Dietary Pattern, the Metabolic Syndrome, and Left Ventricular Mass and Systolic Function: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2009;90(2):362-8. PubMed PMID: 19515735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary pattern, the metabolic syndrome, and left ventricular mass and systolic function: the Multi-Ethnic Study of Atherosclerosis. AU - Liu,Longjian, AU - Nettleton,Jennifer A, AU - Bertoni,Alain G, AU - Bluemke,David A, AU - Lima,João A, AU - Szklo,Moyses, Y1 - 2009/06/10/ PY - 2009/6/12/entrez PY - 2009/6/12/pubmed PY - 2009/8/4/medline SP - 362 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 2 N2 - BACKGROUND: Little is known about the relations between dietary patterns, metabolic dysfunction, and left ventricular (LV) function. OBJECTIVE: The objective was to examine associations of dietary patterns with LV mass and function and to explore the potential role of metabolic dysfunction in the association between diet and LV function. DESIGN: Dietary patterns that maximally explained the variation in metabolic syndrome (MetSyn) components were derived by using reduced rank regression (RRR). LV mass, stroke volume, and LV ejection fraction (LVEF) were measured by magnetic resonance imaging. Associations between dietary pattern and LV indexes were analyzed cross-sectionally. RESULTS: A total of 4601 participants aged 45-84 y and free of clinical cardiovascular disease were studied. The primary RRR dietary pattern score was positively correlated with intake of foods with a high glycemic index, high-fat meats, cheeses, and processed foods and negatively correlated with low intakes of vegetables, soy, fruit, green and black tea, low-fat dairy desserts, seeds and nuts, and fish. Multivariate analyses showed that each 1-unit increase in the RRR dietary pattern score was associated with a 0.32-g/m(2) increase in LV mass/body surface area, a 0.43-mL/m(2) decrease in stroke volume/body surface area, and a 0.21% decrease in LVEF. The associations of the RRR dietary pattern score with LV mass and stroke indexes were attenuated and became nonsignificant after adjustment for all MetSyn components (P > 0.05). CONCLUSIONS: The results suggest that the RRR dietary pattern is significantly associated with unfavorable LV function, and this association might be mediated by metabolic dysfunction. Given the cross-sectional nature of our study, these results must be confirmed with the use of longitudinal data. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19515735/Dietary_pattern_the_metabolic_syndrome_and_left_ventricular_mass_and_systolic_function:_the_Multi_Ethnic_Study_of_Atherosclerosis_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.27538 DB - PRIME DP - Unbound Medicine ER -