TY - JOUR T1 - Genetics in osteoarthritis. AU - Fernández-Moreno,Mercedes, AU - Rego,Ignacio, AU - Carreira-Garcia,Vanessa, AU - Blanco,Francisco J, PY - 2008/06/25/received PY - 2008/08/12/revised PY - 2008/08/13/accepted PY - 2009/6/12/entrez PY - 2009/6/12/pubmed PY - 2009/6/12/medline KW - Osteoarthritis KW - chondrocyte KW - cytokines. KW - genetics SP - 542 EP - 7 JF - Current genomics JO - Curr Genomics VL - 9 IS - 8 N2 - Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse factors interact causing a process of deterioration of the cartilage. Despite the multifactorial nature of this pathology, from the 50's it s known that certain forms of osteoarthritis are related to a strong genetic component. The genetic bases of this disease do not follow the typical patterns of mendelian inheritance and probably they are related to alterations in multiple genes. The identification of a high number of candidate genes to confer susceptibility to the development of the osteoarthritis shows the complex nature of this disease. At the moment, the genetic mechanisms of this disease are not known, however, which seems clear is that expression levels of several genes are altered, and that the inheritance will become a substantial factor in future considerations of diagnosis and treatment of the osteoarthritis. SN - 1389-2029 UR - https://www.unboundmedicine.com/medline/citation/19516961/Genetics_in_osteoarthritis_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1389-2029&volume=9&issue=8&spage=542&aulast=Fernández-Moreno DB - PRIME DP - Unbound Medicine ER -