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Genetics in osteoarthritis.
Curr Genomics. 2008 Dec; 9(8):542-7.CG

Abstract

Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse factors interact causing a process of deterioration of the cartilage. Despite the multifactorial nature of this pathology, from the 50's it s known that certain forms of osteoarthritis are related to a strong genetic component. The genetic bases of this disease do not follow the typical patterns of mendelian inheritance and probably they are related to alterations in multiple genes. The identification of a high number of candidate genes to confer susceptibility to the development of the osteoarthritis shows the complex nature of this disease. At the moment, the genetic mechanisms of this disease are not known, however, which seems clear is that expression levels of several genes are altered, and that the inheritance will become a substantial factor in future considerations of diagnosis and treatment of the osteoarthritis.

Authors+Show Affiliations

Osteoarticular and Aging Research Lab, Genomics Unit. Biomedical Research Center, INIBIC-CH Universitario A Coruña, A Coruña, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19516961

Citation

Fernández-Moreno, Mercedes, et al. "Genetics in Osteoarthritis." Current Genomics, vol. 9, no. 8, 2008, pp. 542-7.
Fernández-Moreno M, Rego I, Carreira-Garcia V, et al. Genetics in osteoarthritis. Curr Genomics. 2008;9(8):542-7.
Fernández-Moreno, M., Rego, I., Carreira-Garcia, V., & Blanco, F. J. (2008). Genetics in osteoarthritis. Current Genomics, 9(8), 542-7. https://doi.org/10.2174/138920208786847953
Fernández-Moreno M, et al. Genetics in Osteoarthritis. Curr Genomics. 2008;9(8):542-7. PubMed PMID: 19516961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics in osteoarthritis. AU - Fernández-Moreno,Mercedes, AU - Rego,Ignacio, AU - Carreira-Garcia,Vanessa, AU - Blanco,Francisco J, PY - 2008/06/25/received PY - 2008/08/12/revised PY - 2008/08/13/accepted PY - 2009/6/12/entrez PY - 2009/6/12/pubmed PY - 2009/6/12/medline KW - Osteoarthritis KW - chondrocyte KW - cytokines. KW - genetics SP - 542 EP - 7 JF - Current genomics JO - Curr Genomics VL - 9 IS - 8 N2 - Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse factors interact causing a process of deterioration of the cartilage. Despite the multifactorial nature of this pathology, from the 50's it s known that certain forms of osteoarthritis are related to a strong genetic component. The genetic bases of this disease do not follow the typical patterns of mendelian inheritance and probably they are related to alterations in multiple genes. The identification of a high number of candidate genes to confer susceptibility to the development of the osteoarthritis shows the complex nature of this disease. At the moment, the genetic mechanisms of this disease are not known, however, which seems clear is that expression levels of several genes are altered, and that the inheritance will become a substantial factor in future considerations of diagnosis and treatment of the osteoarthritis. SN - 1389-2029 UR - https://www.unboundmedicine.com/medline/citation/19516961/full_citation L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1389-2029&volume=9&issue=8&spage=542&aulast=Fernández-Moreno DB - PRIME DP - Unbound Medicine ER -
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