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Recent significant developments in detection and method development for the determination of inorganic ions by CE.
Electrophoresis. 2009 Jun; 30 Suppl 1:S53-67.E

Abstract

CE has been available as a tool for almost 20 years, but it is only in the past several years that it has been implemented widely. This has been the result of some significant advances in the technique. These fall in the areas of indirect photometric detection (through the use of dyes as probes and LEDs as light sources), the introduction and establishment of capacitively-coupled contactless conductivity detection (C4D) as a routine, sensitive and commercially available detection method, and in software capable of simulation of separations and the selection of optimal composition of the BGE. These developments are reviewed and their impact illustrated by reference to a case study involving the rapid separation and sensitive detection of 15 anions and 12 cations on a portable CE instrument. It is shown that C4D provides considerably superior detection sensitivity (by a factor of about 8 in comparison with optimised indirect photometry).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Johns C
Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia.
Breadmore MC
No affiliation info available
Macka M
No affiliation info available
Ryvolová M
No affiliation info available
Haddad PR
No affiliation info available

MeSH

Computer SimulationElectrophoresis, CapillaryEquipment DesignInorganic ChemicalsIonsSensitivity and SpecificityTime Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19517516

Citation

Johns, Cameron, et al. "Recent Significant Developments in Detection and Method Development for the Determination of Inorganic Ions By CE." Electrophoresis, vol. 30 Suppl 1, 2009, pp. S53-67.
Johns C, Breadmore MC, Macka M, et al. Recent significant developments in detection and method development for the determination of inorganic ions by CE. Electrophoresis. 2009;30 Suppl 1:S53-67.
Johns, C., Breadmore, M. C., Macka, M., Ryvolová, M., & Haddad, P. R. (2009). Recent significant developments in detection and method development for the determination of inorganic ions by CE. Electrophoresis, 30 Suppl 1, S53-67. https://doi.org/10.1002/elps.200900103
Johns C, et al. Recent Significant Developments in Detection and Method Development for the Determination of Inorganic Ions By CE. Electrophoresis. 2009;30 Suppl 1:S53-67. PubMed PMID: 19517516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent significant developments in detection and method development for the determination of inorganic ions by CE. AU - Johns,Cameron, AU - Breadmore,Michael C, AU - Macka,Mirek, AU - Ryvolová,Markéta, AU - Haddad,Paul R, PY - 2009/6/12/entrez PY - 2009/6/12/pubmed PY - 2009/8/29/medline SP - S53 EP - 67 JF - Electrophoresis JO - Electrophoresis VL - 30 Suppl 1 N2 - CE has been available as a tool for almost 20 years, but it is only in the past several years that it has been implemented widely. This has been the result of some significant advances in the technique. These fall in the areas of indirect photometric detection (through the use of dyes as probes and LEDs as light sources), the introduction and establishment of capacitively-coupled contactless conductivity detection (C4D) as a routine, sensitive and commercially available detection method, and in software capable of simulation of separations and the selection of optimal composition of the BGE. These developments are reviewed and their impact illustrated by reference to a case study involving the rapid separation and sensitive detection of 15 anions and 12 cations on a portable CE instrument. It is shown that C4D provides considerably superior detection sensitivity (by a factor of about 8 in comparison with optimised indirect photometry). SN - 1522-2683 UR - https://www.unboundmedicine.com/medline/citation/19517516/Recent_significant_developments_in_detection_and_method_development_for_the_determination_of_inorganic_ions_by_CE_ L2 - https://doi.org/10.1002/elps.200900103 DB - PRIME DP - Unbound Medicine ER -