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Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications.

Abstract

Naturally occurring cannabinoids (phytocannabinoids) are biosynthetically related terpenophenolic compounds uniquely produced by the highly variable plant, Cannabis sativa L. Natural and synthetic cannabinoids have been extensively studied since the discovery that the psychotropic effects of cannabis are mainly due to Delta(9)-THC. However, cannabinoids exert pharmacological actions on other biological systems such as the cardiovascular, immune and endocrine systems. Most of these effects have been attributed to the ability of these compounds to interact with the cannabinoid CB1 and CB2 receptors. The FDA approval of Marinol, a product containing synthetic Delta(9)-THC (dronabinol), in 1985 for the control of nausea and vomiting in cancer patients receiving chemotherapy, and in 1992 as an appetite stimulant for AIDS patients, has further intensified the research interest in these compounds. This article reviews patents (2003-2007) that describe methods for isolation of cannabinoids from cannabis, chemical and chromatographic methods for their purification, synthesis, and potential therapeutic applications of these compounds.

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  • Authors+Show Affiliations

    ,

    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. amgalalv@olemiss.edu

    , , , ,

    Source

    MeSH

    Animals
    Appetite Stimulants
    Cannabinoids
    Cardiovascular Diseases
    Cardiovascular System
    Drug Discovery
    Humans
    Psychotropic Drugs
    Receptors, Cannabinoid
    Structure-Activity Relationship

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    19519560

    Citation

    Galal, Ahmed M., et al. "Naturally Occurring and Related Synthetic Cannabinoids and Their Potential Therapeutic Applications." Recent Patents On CNS Drug Discovery, vol. 4, no. 2, 2009, pp. 112-36.
    Galal AM, Slade D, Gul W, et al. Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications. Recent Pat CNS Drug Discov. 2009;4(2):112-36.
    Galal, A. M., Slade, D., Gul, W., El-Alfy, A. T., Ferreira, D., & Elsohly, M. A. (2009). Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications. Recent Patents On CNS Drug Discovery, 4(2), pp. 112-36.
    Galal AM, et al. Naturally Occurring and Related Synthetic Cannabinoids and Their Potential Therapeutic Applications. Recent Pat CNS Drug Discov. 2009;4(2):112-36. PubMed PMID: 19519560.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications. AU - Galal,Ahmed M, AU - Slade,Desmond, AU - Gul,Waseem, AU - El-Alfy,Abir T, AU - Ferreira,Daneel, AU - Elsohly,Mahmoud A, PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/8/19/medline SP - 112 EP - 36 JF - Recent patents on CNS drug discovery JO - Recent Pat CNS Drug Discov VL - 4 IS - 2 N2 - Naturally occurring cannabinoids (phytocannabinoids) are biosynthetically related terpenophenolic compounds uniquely produced by the highly variable plant, Cannabis sativa L. Natural and synthetic cannabinoids have been extensively studied since the discovery that the psychotropic effects of cannabis are mainly due to Delta(9)-THC. However, cannabinoids exert pharmacological actions on other biological systems such as the cardiovascular, immune and endocrine systems. Most of these effects have been attributed to the ability of these compounds to interact with the cannabinoid CB1 and CB2 receptors. The FDA approval of Marinol, a product containing synthetic Delta(9)-THC (dronabinol), in 1985 for the control of nausea and vomiting in cancer patients receiving chemotherapy, and in 1992 as an appetite stimulant for AIDS patients, has further intensified the research interest in these compounds. This article reviews patents (2003-2007) that describe methods for isolation of cannabinoids from cannabis, chemical and chromatographic methods for their purification, synthesis, and potential therapeutic applications of these compounds. SN - 2212-3954 UR - https://www.unboundmedicine.com/medline/citation/19519560/Naturally_occurring_and_related_synthetic_cannabinoids_and_their_potential_therapeutic_applications_ L2 - http://www.eurekaselect.com/84489/article DB - PRIME DP - Unbound Medicine ER -