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Ciguatera incidence and fish toxicity in Okinawa, Japan.
Toxicon. 2010 Oct; 56(5):656-61.T

Abstract

Okinawa being located in the subtropical region has the highest incidence of ciguatera in Japan. Officially, 33 outbreaks involving 103 patients have been reported between 1997 and 2006. The implicated species were Variola louti, Lutjanus bohar, Lutjanus monostigma, Epinephelus fuscoguttatus, unidentified Lutjanus sp., Plectropomus areolatus, Oplegnathus punctatus, Epinephelus polyphekadion, Caranx ignobilis and moray eel. Toxicities of the leftover meals, as determined by mouse bioassays, ranged from 0.025 to 0.8 MU/g or above (equivalent to 0.175-5.6 ngCTX1B/g). We collected 612 specimens of fish belonging to L. monostigma, L. bohar, Lutjanus argentimaculatus, Lutjanus russellii, V. louti, Variola albimarginata, and E. fuscoguttatus from the coasts around Okinawa and examined the toxicity of the flesh by the mouse bioassay. The rate of toxic fish was as follows: L. monostigma: 32.3%, L. bohar: 11.9%, V. louti: 14.3%, E. fuscoguttatus: 20.8%. Only one out of 36 samples of V. albimarginata and two of 74 samples of L. russellii were found toxic. None of the 35 samples of L. argentimaculatus was toxic. Nor the L. bohar samples weighing less than 4 kg were toxic. In all toxic samples, CTX1B was detected by LC/MS analysis but CTX3C and 51-hydroxyCTX3C were not.

Authors+Show Affiliations

Okinawa Prefectural Institute of Health and Environment, Ozato, Nanjo, Okinawa, Japan. ooshronm@pref.okinawa.lg.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19520098

Citation

Oshiro, Naomasa, et al. "Ciguatera Incidence and Fish Toxicity in Okinawa, Japan." Toxicon : Official Journal of the International Society On Toxinology, vol. 56, no. 5, 2010, pp. 656-61.
Oshiro N, Yogi K, Asato S, et al. Ciguatera incidence and fish toxicity in Okinawa, Japan. Toxicon. 2010;56(5):656-61.
Oshiro, N., Yogi, K., Asato, S., Sasaki, T., Tamanaha, K., Hirama, M., Yasumoto, T., & Inafuku, Y. (2010). Ciguatera incidence and fish toxicity in Okinawa, Japan. Toxicon : Official Journal of the International Society On Toxinology, 56(5), 656-61. https://doi.org/10.1016/j.toxicon.2009.05.036
Oshiro N, et al. Ciguatera Incidence and Fish Toxicity in Okinawa, Japan. Toxicon. 2010;56(5):656-61. PubMed PMID: 19520098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ciguatera incidence and fish toxicity in Okinawa, Japan. AU - Oshiro,Naomasa, AU - Yogi,Kentaro, AU - Asato,Shuko, AU - Sasaki,Toshiki, AU - Tamanaha,Koji, AU - Hirama,Masahiro, AU - Yasumoto,Takeshi, AU - Inafuku,Yasuo, Y1 - 2009/06/09/ PY - 2009/01/15/received PY - 2009/05/19/revised PY - 2009/05/19/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2010/12/25/medline SP - 656 EP - 61 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 56 IS - 5 N2 - Okinawa being located in the subtropical region has the highest incidence of ciguatera in Japan. Officially, 33 outbreaks involving 103 patients have been reported between 1997 and 2006. The implicated species were Variola louti, Lutjanus bohar, Lutjanus monostigma, Epinephelus fuscoguttatus, unidentified Lutjanus sp., Plectropomus areolatus, Oplegnathus punctatus, Epinephelus polyphekadion, Caranx ignobilis and moray eel. Toxicities of the leftover meals, as determined by mouse bioassays, ranged from 0.025 to 0.8 MU/g or above (equivalent to 0.175-5.6 ngCTX1B/g). We collected 612 specimens of fish belonging to L. monostigma, L. bohar, Lutjanus argentimaculatus, Lutjanus russellii, V. louti, Variola albimarginata, and E. fuscoguttatus from the coasts around Okinawa and examined the toxicity of the flesh by the mouse bioassay. The rate of toxic fish was as follows: L. monostigma: 32.3%, L. bohar: 11.9%, V. louti: 14.3%, E. fuscoguttatus: 20.8%. Only one out of 36 samples of V. albimarginata and two of 74 samples of L. russellii were found toxic. None of the 35 samples of L. argentimaculatus was toxic. Nor the L. bohar samples weighing less than 4 kg were toxic. In all toxic samples, CTX1B was detected by LC/MS analysis but CTX3C and 51-hydroxyCTX3C were not. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/19520098/Ciguatera_incidence_and_fish_toxicity_in_Okinawa_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(09)00285-2 DB - PRIME DP - Unbound Medicine ER -