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Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats.
Food Chem Toxicol. 2009 Sep; 47(9):2224-9.FC

Abstract

High intake of dietary fructose exerts a number of adverse metabolic effects. The aim of the present study was to investigate whether aqueous extract of Tinospora cordifolia stem (TCAE) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. High-fructose diet (66% of fructose) and TCAE (400 mg/kg/day) were given simultaneously for a period of 60 days. Fructose fed rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia, impaired glucose tolerance and impaired insulin sensitivity (P<0.05). TCAE treatment prevented the rise in glucose levels by 21.3%, insulin by 51.5%, triglycerides by 54.12% and glucose-insulin index by 59.8% of the fructose fed rats. Regarding liver antioxidant status, fructose fed rats showed higher values of lipid peroxidation (91.3%), protein carbonyl groups (44%) and lowered GSH levels (42.1%) and, lowered activities of enzymatic antioxidants, while TCAE treatment prevented all these observed abnormalities. In conclusion, our data indicate the preventive role of T. cordifolia against fructose-induced insulin resistance and oxidative stress; hence this plant could be used as an adjuvant therapy for the prevention and/or management of chronic diseases characterized by hyperinsulinemia, hypertriglyceridemia, insulin resistance and aggravated antioxidant status.

Authors+Show Affiliations

Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19520137

Citation

Reddy, Singareddy Sreenivasa, et al. "Preventive Effect of Tinospora Cordifolia Against High-fructose Diet-induced Insulin Resistance and Oxidative Stress in Male Wistar Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 9, 2009, pp. 2224-9.
Reddy SS, Ramatholisamma P, Karuna R, et al. Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol. 2009;47(9):2224-9.
Reddy, S. S., Ramatholisamma, P., Karuna, R., & Saralakumari, D. (2009). Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(9), 2224-9. https://doi.org/10.1016/j.fct.2009.06.008
Reddy SS, et al. Preventive Effect of Tinospora Cordifolia Against High-fructose Diet-induced Insulin Resistance and Oxidative Stress in Male Wistar Rats. Food Chem Toxicol. 2009;47(9):2224-9. PubMed PMID: 19520137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. AU - Reddy,Singareddy Sreenivasa, AU - Ramatholisamma,Pasurla, AU - Karuna,Rasineni, AU - Saralakumari,Desireddy, Y1 - 2009/06/09/ PY - 2009/02/06/received PY - 2009/04/27/revised PY - 2009/06/05/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/10/14/medline SP - 2224 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 9 N2 - High intake of dietary fructose exerts a number of adverse metabolic effects. The aim of the present study was to investigate whether aqueous extract of Tinospora cordifolia stem (TCAE) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. High-fructose diet (66% of fructose) and TCAE (400 mg/kg/day) were given simultaneously for a period of 60 days. Fructose fed rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia, impaired glucose tolerance and impaired insulin sensitivity (P<0.05). TCAE treatment prevented the rise in glucose levels by 21.3%, insulin by 51.5%, triglycerides by 54.12% and glucose-insulin index by 59.8% of the fructose fed rats. Regarding liver antioxidant status, fructose fed rats showed higher values of lipid peroxidation (91.3%), protein carbonyl groups (44%) and lowered GSH levels (42.1%) and, lowered activities of enzymatic antioxidants, while TCAE treatment prevented all these observed abnormalities. In conclusion, our data indicate the preventive role of T. cordifolia against fructose-induced insulin resistance and oxidative stress; hence this plant could be used as an adjuvant therapy for the prevention and/or management of chronic diseases characterized by hyperinsulinemia, hypertriglyceridemia, insulin resistance and aggravated antioxidant status. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19520137/Preventive_effect_of_Tinospora_cordifolia_against_high_fructose_diet_induced_insulin_resistance_and_oxidative_stress_in_male_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00282-8 DB - PRIME DP - Unbound Medicine ER -