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Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate.
Pediatr Neurol. 2009 Jul; 41(1):9-16.PN

Abstract

This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers. Twenty-six narcoleptic teenagers with recent onset of narcolepsy-cataplexy syndrome who were human leukocyte antigen DQB1 0602 positive were matched for age and sex and received either baclofen or sodium oxybate. If deemed necessary to combat excessive daytime sleepiness, the alerting agent modafinil was also prescribed. Clinical evaluation was performed weekly, and visual analog sleepiness score and cataplexy logs were collected weekly. The Epworth Sleepiness Scale or the Pediatric Daytime Sleepiness Scale, polysomnography, and the Multiple Sleep Latency Test were recorded at baseline and after 3 months of drug intake. The dose of baclofen demonstrating an effect on nocturnal sleep without negative side effects was determined and maintained. Both drugs increased total sleep time and delta waves during sleep, but only sodium oxybate had an effect on daytime sleepiness and cataplexy at 3 months. Improvement of total nocturnal sleep time had no beneficial effect on daytime sleepiness. The mechanism by which sodium oxybate improves cataplexy and sleepiness is inferred to be due to properties beyond direct GABA(B) agonist action.

Authors+Show Affiliations

Sleep Disorders Clinic, Department of Child Psychiatry, Chang Gung University Memorial Hospital, Taipei, Taiwan. Yu_shu_huang@yahoo.comNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19520267

Citation

Huang, Yu-Shu, and Christian Guilleminault. "Narcolepsy: Action of Two Gamma-aminobutyric Acid Type B Agonists, Baclofen and Sodium Oxybate." Pediatric Neurology, vol. 41, no. 1, 2009, pp. 9-16.
Huang YS, Guilleminault C. Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. Pediatr Neurol. 2009;41(1):9-16.
Huang, Y. S., & Guilleminault, C. (2009). Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. Pediatric Neurology, 41(1), 9-16. https://doi.org/10.1016/j.pediatrneurol.2009.02.008
Huang YS, Guilleminault C. Narcolepsy: Action of Two Gamma-aminobutyric Acid Type B Agonists, Baclofen and Sodium Oxybate. Pediatr Neurol. 2009;41(1):9-16. PubMed PMID: 19520267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. AU - Huang,Yu-Shu, AU - Guilleminault,Christian, PY - 2008/04/17/received PY - 2009/02/04/revised PY - 2009/02/10/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/8/28/medline SP - 9 EP - 16 JF - Pediatric neurology JO - Pediatr Neurol VL - 41 IS - 1 N2 - This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers. Twenty-six narcoleptic teenagers with recent onset of narcolepsy-cataplexy syndrome who were human leukocyte antigen DQB1 0602 positive were matched for age and sex and received either baclofen or sodium oxybate. If deemed necessary to combat excessive daytime sleepiness, the alerting agent modafinil was also prescribed. Clinical evaluation was performed weekly, and visual analog sleepiness score and cataplexy logs were collected weekly. The Epworth Sleepiness Scale or the Pediatric Daytime Sleepiness Scale, polysomnography, and the Multiple Sleep Latency Test were recorded at baseline and after 3 months of drug intake. The dose of baclofen demonstrating an effect on nocturnal sleep without negative side effects was determined and maintained. Both drugs increased total sleep time and delta waves during sleep, but only sodium oxybate had an effect on daytime sleepiness and cataplexy at 3 months. Improvement of total nocturnal sleep time had no beneficial effect on daytime sleepiness. The mechanism by which sodium oxybate improves cataplexy and sleepiness is inferred to be due to properties beyond direct GABA(B) agonist action. SN - 1873-5150 UR - https://www.unboundmedicine.com/medline/citation/19520267/Narcolepsy:_action_of_two_gamma_aminobutyric_acid_type_B_agonists_baclofen_and_sodium_oxybate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-8994(09)00082-4 DB - PRIME DP - Unbound Medicine ER -