Tags

Type your tag names separated by a space and hit enter

Four different sublineages of highly pathogenic avian influenza H5N1 introduced in Hungary in 2006-2007.
Vet Microbiol 2009; 139(1-2):24-33VM

Abstract

Highly pathogenic avian influenza (HPAI) H5N1 viruses were introduced to Hungary during 2006-2007 in three separate waves. This study aimed at determining the full-length genomic coding regions of the index strains from these epizootics in order to: (i) understand the phylogenetic relationship to other European H5N1 isolates, (ii) elucidate the possible connection between the different outbreaks and (iii) determine the putative origin and way of introduction of the different virus variants. Molecular analysis of the HA gene of Hungarian HPAI isolates obtained from wild birds during the first introduction revealed two groups designated Hungarian1 (HUN1) and Hungarian2 (HUN2) within sublineage 2.2B and clade 2.2.1, respectively. Sequencing the whole coding region of the two index viruses A/mute swan/Hungary/3472/2006 and A/mute swan/4571/Hungary/2006 suggests the role of wild birds in the introduction of HUN1 and HUN2 viruses: the most similar isolates to HUN1 and HUN2 group were found in wild avian species in Croatia and Slovakia, respectively. The second introduction of HPAI H5N1 led to the largest epizootic in domestic waterfowl in Europe. The index strain of the epizootic A/goose/Hungary/14756/2006 clustered to sublineage 2.2.A1 forming the Hungarian3 (HUN3) group. A common ancestry of HUN3 isolates with Bavarian strains is suggested as the most likely scenario of origin. Hungarian4 (HUN4) viruses isolated from the third introduction clustered with isolate A/turkey/United Kingdom/750/2007 forming a sublineage 2.2.A2. The origin and way of introduction of HUN4 viruses is still obscure, thus further genetic, phylogenetic, ecological and epidemiological data are required in order to elucidate it.

Authors+Show Affiliations

Department of Virology, Central Agricultural Office Veterinary Diagnostic Directorate, Budapest, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19520524

Citation

Szeleczky, Zsófia, et al. "Four Different Sublineages of Highly Pathogenic Avian Influenza H5N1 Introduced in Hungary in 2006-2007." Veterinary Microbiology, vol. 139, no. 1-2, 2009, pp. 24-33.
Szeleczky Z, Dán A, Ursu K, et al. Four different sublineages of highly pathogenic avian influenza H5N1 introduced in Hungary in 2006-2007. Vet Microbiol. 2009;139(1-2):24-33.
Szeleczky, Z., Dán, A., Ursu, K., Ivanics, E., Kiss, I., Erdélyi, K., ... Bálint, A. (2009). Four different sublineages of highly pathogenic avian influenza H5N1 introduced in Hungary in 2006-2007. Veterinary Microbiology, 139(1-2), pp. 24-33. doi:10.1016/j.vetmic.2009.04.017.
Szeleczky Z, et al. Four Different Sublineages of Highly Pathogenic Avian Influenza H5N1 Introduced in Hungary in 2006-2007. Vet Microbiol. 2009 Oct 20;139(1-2):24-33. PubMed PMID: 19520524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four different sublineages of highly pathogenic avian influenza H5N1 introduced in Hungary in 2006-2007. AU - Szeleczky,Zsófia, AU - Dán,Adám, AU - Ursu,Krisztina, AU - Ivanics,Eva, AU - Kiss,István, AU - Erdélyi,Károly, AU - Belák,Sándor, AU - Muller,Claude P, AU - Brown,Ian H, AU - Bálint,Adám, Y1 - 2009/04/19/ PY - 2009/01/06/received PY - 2009/03/31/revised PY - 2009/04/14/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/12/16/medline SP - 24 EP - 33 JF - Veterinary microbiology JO - Vet. Microbiol. VL - 139 IS - 1-2 N2 - Highly pathogenic avian influenza (HPAI) H5N1 viruses were introduced to Hungary during 2006-2007 in three separate waves. This study aimed at determining the full-length genomic coding regions of the index strains from these epizootics in order to: (i) understand the phylogenetic relationship to other European H5N1 isolates, (ii) elucidate the possible connection between the different outbreaks and (iii) determine the putative origin and way of introduction of the different virus variants. Molecular analysis of the HA gene of Hungarian HPAI isolates obtained from wild birds during the first introduction revealed two groups designated Hungarian1 (HUN1) and Hungarian2 (HUN2) within sublineage 2.2B and clade 2.2.1, respectively. Sequencing the whole coding region of the two index viruses A/mute swan/Hungary/3472/2006 and A/mute swan/4571/Hungary/2006 suggests the role of wild birds in the introduction of HUN1 and HUN2 viruses: the most similar isolates to HUN1 and HUN2 group were found in wild avian species in Croatia and Slovakia, respectively. The second introduction of HPAI H5N1 led to the largest epizootic in domestic waterfowl in Europe. The index strain of the epizootic A/goose/Hungary/14756/2006 clustered to sublineage 2.2.A1 forming the Hungarian3 (HUN3) group. A common ancestry of HUN3 isolates with Bavarian strains is suggested as the most likely scenario of origin. Hungarian4 (HUN4) viruses isolated from the third introduction clustered with isolate A/turkey/United Kingdom/750/2007 forming a sublineage 2.2.A2. The origin and way of introduction of HUN4 viruses is still obscure, thus further genetic, phylogenetic, ecological and epidemiological data are required in order to elucidate it. SN - 1873-2542 UR - https://www.unboundmedicine.com/medline/citation/19520524/Four_different_sublineages_of_highly_pathogenic_avian_influenza_H5N1_introduced_in_Hungary_in_2006_2007_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(09)00209-0 DB - PRIME DP - Unbound Medicine ER -