Tags

Type your tag names separated by a space and hit enter

Relaxo-volumetric multispectral quantitative magnetic resonance imaging of the brain over the human lifespan: global and regional aging patterns.

Abstract

The objective of this study was to determine the T1, T2 and secular-T2 relaxo-volumetric brain aging patterns using multispectral quantitative magnetic resonance imaging, both globally and regionally, and covering an age range approaching the full human lifespan. Fifty-one subjects (28 males, 23 females; age range: 0.5-87 years) were studied consisting of 18 healthy volunteers and 33 patients. Patients were selected after carefully reviewing their radiology reports to have either normal-by-MRI findings (25 patient subjects) or small focal pathology less than 6 mm in size (eight patient subjects). All subjects were MR imaged at 1.5 T with the mixed turbo spin echo pulse sequence. The soft tissues inside the cranial vault, termed intracranial matter (ICM), were segmented using a dual-clustering segmentation algorithm. ICM segments were further divided into six subsegments: bilateral anterior cerebral, posterior cerebral and cerebellar subsegments. T1, T2 and secular-T2 relaxation time histograms of all segments were generated and modeled with Gaussian functions. For each segment, the volumes of white matter, gray matter and cerebrospinal fluid were calculated from the T1 histograms. The age-related tendencies of three quantitative MRI parameters (T1, T2 and secular-T2) and the fractional tissue volumes showed four distinct periods of life, specifically a maturation period (0-2 years), a development period (2-20 years), an adulthood period (20-60 years) and a senescence period (60 years and older). For all ages, the anterior cerebral subsegment exhibited consistently longer gray matter T1s and shorter white matter T1s than the posterior cerebral and cerebellar subsegments. Volumetric age-related changes of the cerebellar subsegment were more gradual than in the cerebral subsegments. This study shows that relaxometric and volumetric age-related changes are synchronized and define the same four periods of brain evolution both globally and regionally.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA. naoko.saito.ns@gmail.com

    , ,

    Source

    Magnetic resonance imaging 27:7 2009 Sep pg 895-906

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Aging
    Algorithms
    Brain
    Child
    Child, Preschool
    Female
    Humans
    Image Enhancement
    Image Interpretation, Computer-Assisted
    Imaging, Three-Dimensional
    Infant
    Magnetic Resonance Imaging
    Middle Aged
    Reproducibility of Results
    Sensitivity and Specificity
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19520539

    Citation

    Saito, Naoko, et al. "Relaxo-volumetric Multispectral Quantitative Magnetic Resonance Imaging of the Brain Over the Human Lifespan: Global and Regional Aging Patterns." Magnetic Resonance Imaging, vol. 27, no. 7, 2009, pp. 895-906.
    Saito N, Sakai O, Ozonoff A, et al. Relaxo-volumetric multispectral quantitative magnetic resonance imaging of the brain over the human lifespan: global and regional aging patterns. Magn Reson Imaging. 2009;27(7):895-906.
    Saito, N., Sakai, O., Ozonoff, A., & Jara, H. (2009). Relaxo-volumetric multispectral quantitative magnetic resonance imaging of the brain over the human lifespan: global and regional aging patterns. Magnetic Resonance Imaging, 27(7), pp. 895-906. doi:10.1016/j.mri.2009.05.006.
    Saito N, et al. Relaxo-volumetric Multispectral Quantitative Magnetic Resonance Imaging of the Brain Over the Human Lifespan: Global and Regional Aging Patterns. Magn Reson Imaging. 2009;27(7):895-906. PubMed PMID: 19520539.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relaxo-volumetric multispectral quantitative magnetic resonance imaging of the brain over the human lifespan: global and regional aging patterns. AU - Saito,Naoko, AU - Sakai,Osamu, AU - Ozonoff,Al, AU - Jara,Hernán, Y1 - 2009/06/10/ PY - 2008/11/03/received PY - 2009/01/23/revised PY - 2009/05/06/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/10/29/medline SP - 895 EP - 906 JF - Magnetic resonance imaging JO - Magn Reson Imaging VL - 27 IS - 7 N2 - The objective of this study was to determine the T1, T2 and secular-T2 relaxo-volumetric brain aging patterns using multispectral quantitative magnetic resonance imaging, both globally and regionally, and covering an age range approaching the full human lifespan. Fifty-one subjects (28 males, 23 females; age range: 0.5-87 years) were studied consisting of 18 healthy volunteers and 33 patients. Patients were selected after carefully reviewing their radiology reports to have either normal-by-MRI findings (25 patient subjects) or small focal pathology less than 6 mm in size (eight patient subjects). All subjects were MR imaged at 1.5 T with the mixed turbo spin echo pulse sequence. The soft tissues inside the cranial vault, termed intracranial matter (ICM), were segmented using a dual-clustering segmentation algorithm. ICM segments were further divided into six subsegments: bilateral anterior cerebral, posterior cerebral and cerebellar subsegments. T1, T2 and secular-T2 relaxation time histograms of all segments were generated and modeled with Gaussian functions. For each segment, the volumes of white matter, gray matter and cerebrospinal fluid were calculated from the T1 histograms. The age-related tendencies of three quantitative MRI parameters (T1, T2 and secular-T2) and the fractional tissue volumes showed four distinct periods of life, specifically a maturation period (0-2 years), a development period (2-20 years), an adulthood period (20-60 years) and a senescence period (60 years and older). For all ages, the anterior cerebral subsegment exhibited consistently longer gray matter T1s and shorter white matter T1s than the posterior cerebral and cerebellar subsegments. Volumetric age-related changes of the cerebellar subsegment were more gradual than in the cerebral subsegments. This study shows that relaxometric and volumetric age-related changes are synchronized and define the same four periods of brain evolution both globally and regionally. SN - 1873-5894 UR - https://www.unboundmedicine.com/medline/citation/19520539/Relaxo_volumetric_multispectral_quantitative_magnetic_resonance_imaging_of_the_brain_over_the_human_lifespan:_global_and_regional_aging_patterns_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0730-725X(09)00081-2 DB - PRIME DP - Unbound Medicine ER -