Tags

Type your tag names separated by a space and hit enter

Cardiovascular disease prevention and treatment.
Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep; 81(2-3):193-8.PL

Abstract

The incidence of fatal and non-fatal cardiovascular disease (sudden cardiac death (SCD), myocardial infarction, others) varies, depending on conventional risk factors. However, in Western countries, like the US or Germany, incidences of fatal and non-fatal cardiovascular disease are far higher than in countries like Japan. In the present article, these differences are discussed and related to eicosapentaenoic acid (C20:5omega-3 or C20:5n-3; EPA) and docosahexaenoic acid (C22:6omega-3; DHA). Dietary intake of EPA and DHA and a number of other factors determine levels of EPA and DHA in an individual--best assessed as the omega-3 index, defined as the percentage of EPA and DHA in red cells, and analyzed in a standardized fashion. A review of the literature, expanded by measurements of the omega-3 index, indicates that the risk of sudden cardiac death correlates inversely with the omega-3 index. For persons with an omega-3 index <4%, risk is tenfold, as compared to persons with an omega-3 index >8%. A similar, less-pronounced, correlation exists for non-fatal cardiovascular disease. EPA and DHA have anti-arrhythmic and anti-atherosclerotic mechanisms of action. In large-scale intervention studies, intake of EPA and DHA has been demonstrated to reduce SCD and non-fatal cardiovascular events. Assessing or recommending dietary intake of EPA and DHA does not predict the resulting omega-3 index. Taken together, the omega-3 index is a biomarker to assess a person's content of omega-3 fatty acids, and thus the risk for sudden cardiac death, as well as non-fatal cardiovascular events. EPA and DHA prevent fatal and non-fatal cardiovascular disease and complications of congestive heart failure.

Authors+Show Affiliations

Preventive Cardiology, Medizinische Clinic and Policlinic Innenstadt, University of Munich, Ziemssensstr. 1, D-80336 Munich, Germany. clemens.vonschacky@med.uni-muenchen.de

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19520557

Citation

von Schacky, Clemens. "Cardiovascular Disease Prevention and Treatment." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 81, no. 2-3, 2009, pp. 193-8.
von Schacky C. Cardiovascular disease prevention and treatment. Prostaglandins Leukot Essent Fatty Acids. 2009;81(2-3):193-8.
von Schacky, C. (2009). Cardiovascular disease prevention and treatment. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 81(2-3), 193-8. https://doi.org/10.1016/j.plefa.2009.05.009
von Schacky C. Cardiovascular Disease Prevention and Treatment. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):193-8. PubMed PMID: 19520557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular disease prevention and treatment. A1 - von Schacky,Clemens, Y1 - 2009/06/10/ PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/12/16/medline SP - 193 EP - 8 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 81 IS - 2-3 N2 - The incidence of fatal and non-fatal cardiovascular disease (sudden cardiac death (SCD), myocardial infarction, others) varies, depending on conventional risk factors. However, in Western countries, like the US or Germany, incidences of fatal and non-fatal cardiovascular disease are far higher than in countries like Japan. In the present article, these differences are discussed and related to eicosapentaenoic acid (C20:5omega-3 or C20:5n-3; EPA) and docosahexaenoic acid (C22:6omega-3; DHA). Dietary intake of EPA and DHA and a number of other factors determine levels of EPA and DHA in an individual--best assessed as the omega-3 index, defined as the percentage of EPA and DHA in red cells, and analyzed in a standardized fashion. A review of the literature, expanded by measurements of the omega-3 index, indicates that the risk of sudden cardiac death correlates inversely with the omega-3 index. For persons with an omega-3 index <4%, risk is tenfold, as compared to persons with an omega-3 index >8%. A similar, less-pronounced, correlation exists for non-fatal cardiovascular disease. EPA and DHA have anti-arrhythmic and anti-atherosclerotic mechanisms of action. In large-scale intervention studies, intake of EPA and DHA has been demonstrated to reduce SCD and non-fatal cardiovascular events. Assessing or recommending dietary intake of EPA and DHA does not predict the resulting omega-3 index. Taken together, the omega-3 index is a biomarker to assess a person's content of omega-3 fatty acids, and thus the risk for sudden cardiac death, as well as non-fatal cardiovascular events. EPA and DHA prevent fatal and non-fatal cardiovascular disease and complications of congestive heart failure. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/19520557/Cardiovascular_disease_prevention_and_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(09)00093-3 DB - PRIME DP - Unbound Medicine ER -