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Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place?
Curr Opin Immunol. 2009 Jun; 21(3):308-13.CO

Abstract

Yellow fever 17D vaccine is one of the most successful vaccines ever developed and over 540 million doses have been used. Nevertheless there has been very little known about the mechanism of protection induced by the vaccine. The last couple of years have seen important advances made in understanding how the vaccine works involving studies of the innate and adaptive immune responses plus a systems biology approach. Like all vaccines, the 17D vaccine causes rare serious adverse events (SAEs) following immunization. At present, the mechanism(s) of SAEs is(are) poorly understood but our advances in understanding the immune response induced by the vaccine have promise to help elucidate the mechanism of SAEs.

Authors+Show Affiliations

Sealy Center for Vaccine Development and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0436, USA. abarrett@utmb.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19520559

Citation

Barrett, Alan D T., and Dirk E. Teuwen. "Yellow Fever Vaccine - How Does It Work and Why Do Rare Cases of Serious Adverse Events Take Place?" Current Opinion in Immunology, vol. 21, no. 3, 2009, pp. 308-13.
Barrett AD, Teuwen DE. Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? Curr Opin Immunol. 2009;21(3):308-13.
Barrett, A. D., & Teuwen, D. E. (2009). Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? Current Opinion in Immunology, 21(3), 308-13. https://doi.org/10.1016/j.coi.2009.05.018
Barrett AD, Teuwen DE. Yellow Fever Vaccine - How Does It Work and Why Do Rare Cases of Serious Adverse Events Take Place. Curr Opin Immunol. 2009;21(3):308-13. PubMed PMID: 19520559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? AU - Barrett,Alan D T, AU - Teuwen,Dirk E, Y1 - 2009/06/10/ PY - 2009/05/06/received PY - 2009/05/13/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/9/26/medline SP - 308 EP - 13 JF - Current opinion in immunology JO - Curr Opin Immunol VL - 21 IS - 3 N2 - Yellow fever 17D vaccine is one of the most successful vaccines ever developed and over 540 million doses have been used. Nevertheless there has been very little known about the mechanism of protection induced by the vaccine. The last couple of years have seen important advances made in understanding how the vaccine works involving studies of the innate and adaptive immune responses plus a systems biology approach. Like all vaccines, the 17D vaccine causes rare serious adverse events (SAEs) following immunization. At present, the mechanism(s) of SAEs is(are) poorly understood but our advances in understanding the immune response induced by the vaccine have promise to help elucidate the mechanism of SAEs. SN - 1879-0372 UR - https://www.unboundmedicine.com/medline/citation/19520559/Yellow_fever_vaccine___how_does_it_work_and_why_do_rare_cases_of_serious_adverse_events_take_place L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-7915(09)00099-5 DB - PRIME DP - Unbound Medicine ER -