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Ventricular reverse remodeling early after mitral valve repair for severe chronic mitral regurgitation with atrial fibrillation.
Cardiology. 2009; 114(2):132-41.C

Abstract

OBJECTIVE

Chronic mitral regurgitation (MR) results in volume overload followed by left ventricular (LV) and left atrial remodeling. The aim of this study was to investigate the relation of clinical, echocardiographic findings and N-terminal B-type natriuretic peptide (NT-proBNP) to LV reverse remodeling (LVRR) early after valve repair for severe chronic MR concomitant with modified maze procedure for atrial fibrillation (AF).

METHODS

We retrospectively evaluated 60 patients who were surgically treated for severe chronic MR and AF. Plasma NT-proBNP and echocardiographic measurements were performed before surgery, before discharge and 12 months after surgery. Echocardiogram was additionally performed at 6 months. LVRR was assessed by looking at regression of LV mass index (LVMI) using echocardiography.

RESULTS

Fifty-two patients (87%) were classified in the LVRR group, defined as having a postoperative reduction in LVMI. The remaining patients were classified in the non-LVRR group. The non-LVRR group was older (p = 0.004), had a significantly higher ratio of patients with hypertension (p = 0.022), higher NT-proBNP levels (p = 0.007) and lower ejection fraction (p = 0.034) compared to the LVRR group. In multivariate analysis, age (odds ratio 0.874, p = 0.013) and NT-proBNP levels (odds ratio 0.185, p = 0.040) were independent predictors of LVRR.

CONCLUSIONS

Preoperative lower NT-proBNP levels and younger age may predict LVRR early after surgical correction of chronic MR with AF.

Authors+Show Affiliations

Division of Cardiology, Cardiac and Vascular Center, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19521078

Citation

Song, Bong Gun, et al. "Ventricular Reverse Remodeling Early After Mitral Valve Repair for Severe Chronic Mitral Regurgitation With Atrial Fibrillation." Cardiology, vol. 114, no. 2, 2009, pp. 132-41.
Song BG, On YK, Jeon ES, et al. Ventricular reverse remodeling early after mitral valve repair for severe chronic mitral regurgitation with atrial fibrillation. Cardiology. 2009;114(2):132-41.
Song, B. G., On, Y. K., Jeon, E. S., Park, J. H., Choi, J. O., Lee, S. C., Park, S. W., Kim, J. S., & Park, P. W. (2009). Ventricular reverse remodeling early after mitral valve repair for severe chronic mitral regurgitation with atrial fibrillation. Cardiology, 114(2), 132-41. https://doi.org/10.1159/000224770
Song BG, et al. Ventricular Reverse Remodeling Early After Mitral Valve Repair for Severe Chronic Mitral Regurgitation With Atrial Fibrillation. Cardiology. 2009;114(2):132-41. PubMed PMID: 19521078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ventricular reverse remodeling early after mitral valve repair for severe chronic mitral regurgitation with atrial fibrillation. AU - Song,Bong Gun, AU - On,Young Keun, AU - Jeon,Eun-Seok, AU - Park,Ji Han, AU - Choi,Jin-Oh, AU - Lee,Sang-Chol, AU - Park,Seung Woo, AU - Kim,June Soo, AU - Park,Pyo Won, Y1 - 2009/06/12/ PY - 2008/11/20/received PY - 2009/01/07/accepted PY - 2009/6/13/entrez PY - 2009/6/13/pubmed PY - 2009/12/16/medline SP - 132 EP - 41 JF - Cardiology JO - Cardiology VL - 114 IS - 2 N2 - OBJECTIVE: Chronic mitral regurgitation (MR) results in volume overload followed by left ventricular (LV) and left atrial remodeling. The aim of this study was to investigate the relation of clinical, echocardiographic findings and N-terminal B-type natriuretic peptide (NT-proBNP) to LV reverse remodeling (LVRR) early after valve repair for severe chronic MR concomitant with modified maze procedure for atrial fibrillation (AF). METHODS: We retrospectively evaluated 60 patients who were surgically treated for severe chronic MR and AF. Plasma NT-proBNP and echocardiographic measurements were performed before surgery, before discharge and 12 months after surgery. Echocardiogram was additionally performed at 6 months. LVRR was assessed by looking at regression of LV mass index (LVMI) using echocardiography. RESULTS: Fifty-two patients (87%) were classified in the LVRR group, defined as having a postoperative reduction in LVMI. The remaining patients were classified in the non-LVRR group. The non-LVRR group was older (p = 0.004), had a significantly higher ratio of patients with hypertension (p = 0.022), higher NT-proBNP levels (p = 0.007) and lower ejection fraction (p = 0.034) compared to the LVRR group. In multivariate analysis, age (odds ratio 0.874, p = 0.013) and NT-proBNP levels (odds ratio 0.185, p = 0.040) were independent predictors of LVRR. CONCLUSIONS: Preoperative lower NT-proBNP levels and younger age may predict LVRR early after surgical correction of chronic MR with AF. SN - 1421-9751 UR - https://www.unboundmedicine.com/medline/citation/19521078/Ventricular_reverse_remodeling_early_after_mitral_valve_repair_for_severe_chronic_mitral_regurgitation_with_atrial_fibrillation_ L2 - https://www.karger.com?DOI=10.1159/000224770 DB - PRIME DP - Unbound Medicine ER -